{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T09:34:34Z","timestamp":1781948074342,"version":"3.54.5"},"reference-count":32,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,5]]},"abstract":"<jats:p>The chikungunya virus (CHIKV) epidemic in the Americas is of significant public health importance due to the lack of effective control and prevention strategies, severe disease morbidity among susceptible populations, and potential for persistent arthralgia and long-term impaired physical functionality. Using surveillance data of suspected CHIKV cases, we describe the first reported outbreak in the U.S. Virgin Islands. CHIKV incidence was highest among individuals aged 55\u201364 years (13.1 cases per 1,000 population) and lowest among individuals aged 0\u201314 years (1.8 cases per 1,000 population). Incidence was higher among women compared to men (6.6 and 5.0 cases per 1,000 population, respectively). More than half of reported laboratory-positive cases experienced fever lasting 2\u20137 days, chills\/rigor, myalgia, anorexia, and headache. No clinical symptoms apart from the suspected case definition of fever \u2265 38\u00b0C and arthralgia were significantly associated with being a reported laboratory-positive case. These results contribute to our knowledge of demographic risk factors and clinical manifestations of CHIKV disease and may aid in mitigating future CHIKV outbreaks in the Caribbean.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0288","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T06:25:38Z","timestamp":1468304738000},"page":"885-889","source":"Crossref","is-referenced-by-count":26,"title":["The First Reported Outbreak of Chikungunya in the U.S. Virgin Islands, 2014\u20132015"],"prefix":"10.4269","volume":"95","author":[{"given":"Leora R.","family":"Feldstein","sequence":"first","affiliation":[{"name":"1Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington."},{"name":"2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther M.","family":"Ellis","sequence":"additional","affiliation":[{"name":"3U.S. Virgin Islands Department of Health, Saint Croix, U.S. Virgin Islands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Rowhani-Rahbar","sequence":"additional","affiliation":[{"name":"1Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Elizabeth","family":"Halloran","sequence":"additional","affiliation":[{"name":"2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington."},{"name":"4Center for Inference and Dynamics of Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington."},{"name":"5Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett R.","family":"Ellis","sequence":"additional","affiliation":[{"name":"3U.S. Virgin Islands Department of Health, Saint Croix, U.S. Virgin Islands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Chikungunya Virus","author":"Centers for Disease Control and Prevention","year":"2016"},{"key":"ref2","series-title":"S Afr Med J","first-page":"313","article-title":"Chikungunya virus infection. A retrospective study of 107 cases","volume":"63","author":"Brighton","year":"1983"},{"key":"ref3","series-title":"Nat Clin Pract Rheumatol","first-page":"2","article-title":"Emerging viral infections and arthritis: the role of the rheumatologist","volume":"4","author":"Calabrese","year":"2008"},{"key":"ref4","series-title":"PLoS Negl Trop Dis","first-page":"e2137","article-title":"Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study","volume":"7","author":"Schilte","year":"2013"},{"key":"ref5","series-title":"Lancet Infect Dis","first-page":"2","article-title":"Clinical burden of chikungunya virus infection","volume":"8","author":"Queyriaux","year":"2008"},{"key":"ref6","series-title":"Epidemiol Infect","first-page":"534","article-title":"Atypical chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005\u20132006 outbreak on R\u00e9union","volume":"137","author":"Economopoulou","year":"2009"},{"key":"ref7","series-title":"PLoS Negl Trop Dis","first-page":"e1446","article-title":"Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia","volume":"6","author":"Dupuis-Maguiraga","year":"2012"},{"key":"ref8","series-title":"Expert Rev Vaccines","first-page":"1087","article-title":"Chikungunya virus and prospects for a vaccine","volume":"11","author":"Weaver","year":"2012"},{"key":"ref9","series-title":"New Microbiol","first-page":"211","article-title":"Chikungunya virus infection: an overview","volume":"36","author":"Caglioti","year":"2013"},{"key":"ref10","series-title":"Notes from the Field: Chikungunya Virus Spreads in the Americas: Caribbean and South America, 2013\u20132014","author":"Fischer","year":"2014"},{"key":"ref11","series-title":"The CIA World Factbook, U.S. Virgin Islands","author":"Central Intelligence Agency","year":"2014"},{"key":"ref12","series-title":"J Postgrad Med","first-page":"3","article-title":"Persistent arthralgia among chikungunya patients and associated risk factors in Chennai, south India","volume":"60","author":"Ramachandran","year":"2014"},{"key":"ref13","series-title":"Infect Dis Ther","first-page":"63","article-title":"Chikungunya in the Caribbean: an epidemic in the making","volume":"3","author":"Mowatt","year":"2014"},{"key":"ref14","series-title":"Cruise Passenger Arrivals: U.S. Virgin Islands, 2014","author":"U.S.V.I. Bureau of Economic Research","year":"2014"},{"key":"ref15","series-title":"Air Visitor Arrivals: U.S. Virgin Islands, 2014","author":"U.S.V.I. Bureau of Economic Research","year":"2014"},{"key":"ref16","series-title":"Chikungunya Surveillance Weekly Report: US Virgin Islands Department of Health","author":"Ellis","year":"2015"},{"key":"ref17","series-title":"Revised Diagnostic Testing for Zika, Chikungunya, and Dengue Viruses in US Public Health Laboratories","author":"Centers for Disease Control and Prevention","year":"2016"},{"key":"ref18","series-title":"Guidelines for Prevention and Control of Chikungunya Fever","author":"World Health Organization","year":"2009"},{"key":"ref19","series-title":"Stata Statistical Software: Release 12","author":"StataCorp","year":"2011"},{"key":"ref20","series-title":"Rev Saude Publica","first-page":"992","article-title":"Methods for estimating prevalence ratios in cross-sectional studies","volume":"42","author":"Coutinho","year":"2008"},{"key":"ref21","series-title":"PLoS Negl Trop Dis","first-page":"e481","article-title":"The role of human movement in the transmission of vector-borne pathogens","volume":"3","author":"Stoddard","year":"2009"},{"key":"ref22","series-title":"PLoS One","first-page":"e3066","article-title":"Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005\u20132006: a population-based survey","volume":"3","author":"Sissoko","year":"2008"},{"key":"ref23","series-title":"PLoS Negl Trop Dis","first-page":"e0004625","article-title":"First chikungunya outbreak in Suriname; clinical and epidemiological features","volume":"10","author":"van Genderen","year":"2016"},{"key":"ref24","series-title":"Am J Trop Med Hyg","first-page":"393","article-title":"Seroprevalence of Asian lineage chikungunya virus infection on Saint Martin Island, 7 months after the 2013 emergence","volume":"94","author":"Gay","year":"2016"},{"key":"ref25","series-title":"Med Mal Infect","first-page":"253","article-title":"Chikungunya virus infection: review through an epidemic [in French]","volume":"36","author":"Pialoux","year":"2006"},{"key":"ref26","series-title":"Epidemiol Infect","first-page":"842","article-title":"Acute chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study","volume":"140","author":"Chopra","year":"2012"},{"key":"ref27","series-title":"J Clin Virol","first-page":"111","article-title":"Chikungunya fever in Singapore: acute clinical and laboratory features, and factors associated with persistent arthralgia","volume":"49","author":"Win","year":"2010"},{"key":"ref28","series-title":"J Clin Virol","first-page":"141","article-title":"Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia","volume":"56","author":"Mohd Zim","year":"2013"},{"key":"ref29","series-title":"Med Vet Entomol","first-page":"451","article-title":"Mark-release-recapture study to measure dispersal of the mosquito Aedes aegypti in Cairns, Queensland, Australia","volume":"19","author":"Russell","year":"2005"},{"key":"ref30","series-title":"J Am Mosq Control Assoc","first-page":"74","article-title":"Diel activity patterns of male Aedes albopictus in the laboratory","volume":"29","author":"Boyer","year":"2013"},{"key":"ref31","series-title":"Am J Trop Med Hyg","first-page":"494","article-title":"Characteristics of the spatial pattern of the dengue vector, Aedes aegypti, in Iquitos, Peru","volume":"69","author":"Getis","year":"2003"},{"issue":"(Suppl 4)","key":"ref32","series-title":"Trop Med Health","first-page":"3","article-title":"Dengue, urbanization and globalization: the unholy trinity of the 21st century","volume":"39","author":"Gubler","year":"2011"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/4\/article-p885.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/4\/article-p885.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/4\/article-p885.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:55:08Z","timestamp":1723067708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/4\/article-p885.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,5]]},"references-count":32,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.16-0288","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,5]]}}}