{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:13:12Z","timestamp":1792026792683,"version":"4.4.0"},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>The impact of chikungunya virus (CHIKV) infection on diabetic patients (DPs) has not been described. We aimed to compare clinical features of CHIKV infection in DPs and nondiabetic patients (NDPs), and to evaluate its effects on glycemic control among DPs. We recorded clinical information and, in DPs, glycemic control. Forty-six DPs and 53 NDPs aged \u2265 20 years living in Haiti, with acute CHIKV infection, were studied. Diabetes duration was 7.1 \u00b1 6.1 years. The most common acute CHIKV clinical manifestations were arthralgia (100.0% DPs and 98.1% NDPs, <jats:italic>P<\/jats:italic> = 1.000) and fever (86.9% DPs and 90.5% NDPs, <jats:italic>P<\/jats:italic> = 0.750). In DPs as compared with NDPs, arthralgia was more intense (mean pain score of 6.0\/10 \u00b1 2.2 versus 5.1\/10 \u00b1 2.0, <jats:italic>P<\/jats:italic> = 0.04) and took longer to improve (8.2 \u00b1 3.0 versus 3.5 \u00b1 2.5 days, <jats:italic>P<\/jats:italic> &lt; 0.0001). Severe arthralgia was more prevalent (58.7% versus 20.8%, <jats:italic>P<\/jats:italic> = 0.0002), as was myalgia (80.4% versus 50.9%, <jats:italic>P<\/jats:italic> = 0.003), and fever lasted longer (5.1 \u00b1 1.8 versus 3.7 \u00b1 1.7 days, <jats:italic>P<\/jats:italic> = 0.0002). Among DPs, median fasting capillary glucose before versus after disease onset was 132.5 and 167.5 mg\/dL (<jats:italic>P<\/jats:italic> &lt; 0.001), corresponding to a median increase of 26.8% (interquartile range: 14.4\u201350.1%). Antidiabetic medication was titrated up in 41.3%. In summary, among DPs, CHIKV infection has a significant negative impact on glycemic control and, compared with NDPs, results in greater morbidity. Close clinical and glycemic observation is recommended in DPs with CHIKV infection.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0320","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T17:09:41Z","timestamp":1476205781000},"page":"1345-1350","source":"Crossref","is-referenced-by-count":28,"title":["Chikungunya Virus Infection and Diabetes Mellitus: A Double Negative Impact"],"prefix":"10.4269","volume":"95","author":[{"given":"Eddy","family":"Jean-Baptiste","sequence":"first","affiliation":[{"name":"FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"von Oettingen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Montreal Children's Hospital, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Larco","sequence":"additional","affiliation":[{"name":"FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rica","family":"Rapha\u00ebl","sequence":"additional","affiliation":[{"name":"FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Charles","family":"Larco","sequence":"additional","affiliation":[{"name":"FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Marcelle","family":"Cauvin","sequence":"additional","affiliation":[{"name":"FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Charles","sequence":"additional","affiliation":[{"name":"FHADIMAC (Haitian Foundation of Diabetes and Cardiovascular Diseases), Port-au-Prince, Haiti."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"N Engl J Med","first-page":"1231","article-title":"Chikungunya virus and the global spread of a mosquito-borne disease","volume":"372","author":"Weaver","year":"2015"},{"key":"ref2","series-title":"Clin Infect Dis","first-page":"942","article-title":"Chikungunya fever: an epidemiological review of a re-emerging infectious disease","volume":"49","author":"Staples","year":"2009"},{"key":"ref3","series-title":"Trans R Soc Trop Med Hyg","first-page":"89","article-title":"Atypical manifestations of chikungunya infection","volume":"104","author":"Rajapakse","year":"2010"},{"key":"ref4","series-title":"Epidemiol Infect","first-page":"534","article-title":"Atypical chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005\u20132006 outbreak on R\u00e9union","volume":"137","author":"Economopoulou","year":"2009"},{"key":"ref5","series-title":"Chikungunya. 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