{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:46:59Z","timestamp":1790282819549,"version":"4.1.0"},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,11]]},"abstract":"<jats:p>A 30-year-old male, from a subtropical region of Ecuador, was hospitalized with a 5-year history of persistent cough with rusty brown sputum, chest pain, and progressive dyspnea. The patient underwent thoracic surgery 3 years ago for pleural effusion and subsequently received a 9-month regimen treatment of tuberculosis. However, there was no clinical resolution and symptoms became progressively worse. A chest radiograph and computerized tomography scan showed several small nodules in both lungs. Eggs of <jats:italic>Paragonimus<\/jats:italic> spp. were observed in sputum smears, but the smears were negative for acid-fast bacilli. Molecular characterization of eggs by the internal transcribed spacer-2 regions identified them as <jats:italic>Paragonimus mexicanus<\/jats:italic>. The patient was treated with praziquantel and tested negative parasitologically for 12 months. There was clinical resolution of the cough and expectoration, but dyspnea and chest pain persisted.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0351","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T03:00:16Z","timestamp":1479870016000},"page":"97-99","source":"Crossref","is-referenced-by-count":18,"title":["Severe Pleuropulmonary Paragonimiasis Caused by Paragonimus mexicanus Treated as Tuberculosis in Ecuador"],"prefix":"10.4269","volume":"96","author":[{"given":"Manuel","family":"Calvopina","sequence":"first","affiliation":[{"name":"Unidad de Parasitolog\u00eda Molecular y Medicina Tropical, Carrera de Medicina, Universidad De Las Am\u00e9ricas (UDLA), Quito, Ecuador."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Romero-Alvarez","sequence":"additional","affiliation":[{"name":"Unidad de Parasitolog\u00eda Molecular y Medicina Tropical, Carrera de Medicina, Universidad De Las Am\u00e9ricas (UDLA), Quito, Ecuador."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Macias","sequence":"additional","affiliation":[{"name":"Hospital Carlos Andrade Mar\u00edn, Instituto Ecuatoriano de Seguridad Social, Quito, Ecuador."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromu","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Working to Overcome the Global Impact of Neglected Tropical Diseases: First WHO Report on Neglected Tropical Diseases","author":"Daumerie","year":"2010"},{"key":"ref2","series-title":"Mem Inst Oswaldo Cruz","first-page":"849","article-title":"Current status of Paragonimus and paragonimiasis in Ecuador","volume":"109","author":"Calvopina","year":"2014"},{"key":"ref3","series-title":"Zoonosis y Enfermedades Transmisibles Comunes al Hombre y a los Animales: Parasitosis","first-page":"158","article-title":"Paragonimiasis","volume":"Volume 3","author":"Acha","year":"2003"},{"key":"ref4","series-title":"Semin Respir Crit Care Med","first-page":"35","article-title":"Pulmonary paragonimiasis: a Korean perspective","volume":"12","author":"Shim","year":"1991"},{"key":"ref5","series-title":"Am J Roentgenol","first-page":"39","article-title":"Pleuropulmonary paragonimiasis: radiologic findings in 71 patients","volume":"159","author":"Im","year":"1992"},{"key":"ref6","series-title":"Chin Med J (Engl)","first-page":"483","article-title":"Recent progress in studies of Paragonimus and paragonimiasis control in China","volume":"94","author":"Zhong","year":"1981"},{"key":"ref7","series-title":"Rev Fac Cienc Med","first-page":"253","article-title":"Paragonimiasis pulmonar. Revisi\u00f3n cl\u00ednica de 92 casos","volume":"6","author":"Pe\u00f1afiel","year":"1981"},{"key":"ref8","series-title":"Trans R Soc Trop Med Hyg","first-page":"967","article-title":"Pulmonary paragonimiasis: clinical features, diagnosis and treatment of 39 cases in Manipur","volume":"80","author":"Singh","year":"1986"},{"key":"ref9","series-title":"Molecular Detection of Human Parasitic Pathogens","first-page":"423","article-title":"Paragonimus","author":"Sugiyama","year":"2013"},{"key":"ref10","series-title":"Control de la Paragonimiasis en el Ecuador","first-page":"1","author":"D\u00edaz","year":"1991"},{"key":"ref11","series-title":"Arch Bronconeumol","first-page":"610","article-title":"Pulmonary paragonimiasis","volume":"47","author":"G\u00f3mez-Seco","year":"2011"},{"key":"ref12","series-title":"Pathog Glob Health","first-page":"40","article-title":"Pleuropulmonary paragonimiasis: mimicker of tuberculosis","volume":"107","author":"Lall","year":"2013"},{"key":"ref13","series-title":"Manual de Normas y Procedimientos para el Control de la Tuberculosis","first-page":"1","author":"Ministerio de Salud P\u00fablica del Ecuador","year":"2010"},{"key":"ref14","series-title":"Am J Roentgenol","first-page":"616","article-title":"Pleuropulmonary paragonimiasis: CT findings in 31 patients","volume":"185","author":"Kim","year":"2005"},{"key":"ref15","series-title":"PLoS Negl Trop Dis","first-page":"1","article-title":"Ziehl-Neelsen staining technique can diagnose paragonimiasis","volume":"5","author":"Slesak","year":"2011"},{"key":"ref16","series-title":"Cuadro Nacional de Medicamentos B\u00e1sicos y Registro Terap\u00e9utico","first-page":"586","author":"Consejo Nacional de Salud","year":"2014"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/96\/1\/article-p97.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/96\/1\/article-p97.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/96\/1\/article-p97.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:37:15Z","timestamp":1723070235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/96\/1\/article-p97.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,11]]},"references-count":16,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.16-0351","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,11]]}}}