{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:39:52Z","timestamp":1773484792561,"version":"3.50.1"},"reference-count":29,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Previous studies have demonstrated that household contacts of cholera patients are highly susceptible to cholera infections for a 7-day period after the presentation of the index patient in the hospital. However, there is no standard of care to prevent cholera transmission in this high-risk population. Furthermore, there is limited information available on awareness of cholera transmission and prevention among cholera patients and their household contacts. To initiate a standard of care for this high-risk population, we developed the Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which delivers a handwashing with soap and water treatment intervention to household contacts during the time they spend with the admitted cholera patient in the hospital and reinforces these messages through home visits. To test CHoBI7, we conducted a randomized controlled trial among 302 intervention cholera patient household members and 302 control cholera patient household members in Dhaka, Bangladesh. In this study, we evaluated the effectiveness of the CHoBI7 intervention in increasing awareness of cholera transmission and prevention, and the key times for handwashing with soap. We observed a significant increase in cholera knowledge score in the intervention arm compared with the control arm at both the 1-week follow-up {score coefficient = 2.34 (95% confidence interval [CI] = 1.96, 2.71)} and 6 to 12-month follow-up period (score coefficient = 1.59 [95% CI = 1.05, 2.13]). This 1-week hospital- and home-based intervention led to a significant increase in knowledge of cholera transmission and prevention which was sustained 6 to 12 months post-intervention. These findings suggest that the CHoBI7 intervention presents a promising approach to increase cholera awareness among this high-risk population.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0378","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T17:09:41Z","timestamp":1476205781000},"page":"1292-1298","source":"Crossref","is-referenced-by-count":9,"title":["Promotion of Cholera Awareness Among Households of Cholera Patients: A Randomized Controlled Trial of the Cholera-Hospital-Based-Intervention-for-7 Days (CHoBI7) Intervention"],"prefix":"10.4269","volume":"95","author":[{"given":"K. M.","family":"Saif-Ur-Rahman","sequence":"first","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahmina","family":"Parvin","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sazzadul Islam","family":"Bhuyian","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema","family":"Zohura","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzana","family":"Begum","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahamud-Ur","family":"Rashid","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shwapon Kumar","family":"Biswas","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sack","sequence":"additional","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Bradley","family":"Sack","sequence":"additional","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirajum","family":"Monira","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munirul","family":"Alam","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusrat Jahan","family":"Shaly","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine Marie","family":"George","sequence":"additional","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Lancet Infect Dis","first-page":"521","article-title":"The true burden and risk of cholera: implications for prevention and control","volume":"7","author":"Zuckerman","year":"2007"},{"key":"ref2","series-title":"PLoS Negl Trop Dis","first-page":"e0003832","article-title":"Updated global burden of cholera in endemic countries","volume":"9","author":"Ali","year":"2015"},{"key":"ref3","series-title":"PLoS Negl Trop Dis","first-page":"e221","article-title":"Susceptibility to Vibrio cholerae infection in a cohort of household contacts of patients with cholera in Bangladesh","volume":"2","author":"Harris","year":"2008"},{"key":"ref4","series-title":"Bull World Health 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