{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:23:57Z","timestamp":1789590237880,"version":"build-2803163510"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,3]]},"abstract":"<jats:p>\n                    Rickettsial infections are recognized as important causes of fever throughout southeast Asia. Herein, we determined the seroprevalence to rickettsioses within rural and urban populations of northern Vietnam. Prevalence of individuals with evidence of prior rickettsial infections (IgG positive) was surprisingly low, with 9.14% (83\/908) testing positive to the three major rickettsial serogroups thought to circulate in the region. Prevalence of typhus group rickettsiae (TG)\u2013specific antibodies (6.5%, 58\/908) was significantly greater than scrub typhus group orientiae (STG)\u2013 or spotted fever group rickettsiae (SFG)\u2013specific antibodies (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). The majority of TG seropositives were observed among urban rather than rural residents (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). In contrast, overall antibody prevalence to STG and SFG were both very low (1.1%, 10\/908 for STG; 1.7%, 15\/908 for SFG), with no significant differences between rural and urban residents. These results provide data on baseline population characteristics that may help inform development of\n                    <jats:italic>Rickettsia<\/jats:italic>\n                    serological testing criteria in future clinical studies.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.16-0399","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T13:08:07Z","timestamp":1489496887000},"page":"1084-1087","source":"Crossref","is-referenced-by-count":31,"title":["Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam"],"prefix":"10.4269","volume":"96","author":[{"given":"Nguyen vu","family":"Trung","sequence":"first","affiliation":[{"name":"National Hospital for Tropical Diseases, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi","family":"Hoi","sequence":"additional","affiliation":[{"name":"National Hospital for Tropical Diseases, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Hong","family":"Thuong","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Khanh","family":"Toan","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Thi Kieu","family":"Huong","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Mai","family":"Hoa","sequence":"additional","affiliation":[{"name":"National Hospital for Tropical Diseases, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Fox","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam."},{"name":"Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen van","family":"Kinh","sequence":"additional","affiliation":[{"name":"National Hospital for Tropical Diseases, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Rogier","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam."},{"name":"Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiman F. L.","family":"Wertheim","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam."},{"name":"Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."},{"name":"Department of Medical Microbiology, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet E.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam."},{"name":"Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Nadjm","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit and Wellcome Trust Major Overseas Programme, Hanoi, Vietnam."},{"name":"Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"PLoS One","first-page":"e44269","article-title":"Mapping the aetiology of non-malarial febrile illness in southeast Asia through a systematic review: terra incognita impairing treatment policies","volume":"7","author":"Acestor","year":"2012"},{"key":"ref2","series-title":"Am J Trop Med Hyg","first-page":"451","article-title":"Rickettsial infections in southeast Asia: implications for local populace and febrile returned travelers","volume":"91","author":"Aung","year":"2014"},{"key":"ref3","series-title":"FEMS Immunol Med Microbiol","first-page":"107","article-title":"Worldwide detection and identification of new and old rickettsiae and rickettsial 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and TT118 spotted fever group rickettsiae among Malaysian blood donors and febrile patients in the urban areas","volume":"34","author":"Tay","year":"2003"},{"key":"ref19","series-title":"Am J Trop Med Hyg","first-page":"149","article-title":"Prevalence of antibodies to rickettsiae in the human population of suburban Bangkok","volume":"51","author":"Strickman","year":"1994"},{"key":"ref20","series-title":"Infect Genet Evol","first-page":"35","article-title":"Molecular epidemiology of Orientia tsutsugamushi in Cambodia and central Vietnam reveals a broad region-wide genetic diversity","volume":"15","author":"Duong","year":"2013"}],"container-title":["The American Society of Tropical Medicine and 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