{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:33:07Z","timestamp":1792611187405,"version":"4.5.0"},"reference-count":21,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Despite previous evidence of high level of efficacy, no synthetic metric of yellow fever (YF) vaccine efficacy is currently available. Based on the studies identified in a recent systematic review, we conducted a random-effects meta-analysis of the serological response associated with YF vaccination. Eleven studies conducted between 1965 and 2011 representing 4,868 individual observations were included in the meta-analysis. The pooled estimate of serological response was 97.5% (95% confidence interval [CI] = 82.9\u201399.7%). There was evidence of between-study heterogeneity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 89.1%), but this heterogeneity did not appear to be related to study size, study design, or seroconversion measurement or definition. Pooled estimates were significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.0001) among studies conducted in nonendemic settings (98.9%, 95% CI = 98.2\u201399.4%) than among those conducted in endemic settings (94.2%, 95% CI = 83.8\u201398.1%). These results provide background information against which to evaluate the efficacy of fractional doses of YF vaccine that may be used in outbreak situations.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0401","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T17:09:41Z","timestamp":1476205781000},"page":"1435-1439","source":"Crossref","is-referenced-by-count":40,"title":["A Meta-Analysis of Serological Response Associated with Yellow Fever Vaccination"],"prefix":"10.4269","volume":"95","author":[{"given":"K\u00e9vin","family":"Jean","sequence":"first","affiliation":[{"name":"MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christl A.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tini","family":"Garske","sequence":"additional","affiliation":[{"name":"MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"PLoS Med","first-page":"e1001638","article-title":"Yellow fever in Africa: estimating the burden of disease and impact of mass vaccination from outbreak and serological data","volume":"11","author":"Garske","year":"2014"},{"key":"ref2","series-title":"Situation Report: Yellow Fever Outbreak in Angola, 4 July 2016","author":"World Health Organization\u2013Incident Management Team Angola","year":"2016"},{"key":"ref3","series-title":"Yale J Biol Med","first-page":"77","article-title":"The yellow fever vaccine: a history","volume":"83","author":"Frierson","year":"2010"},{"key":"ref4","series-title":"Am J Trop Med Hyg","first-page":"434","article-title":"Efficacy and duration of immunity after yellow fever vaccination: systematic review on the need for a booster every 10 years","volume":"89","author":"Gotuzzo","year":"2013"},{"key":"ref5","series-title":"Wkly Epidemiol Rec","first-page":"269","article-title":"Vaccines and vaccination against yellow fever. WHO position paper: June 2013","volume":"88","author":"World Health Organization","year":"2013"},{"key":"ref6","series-title":"Rev Invest (Guadalajara)","first-page":"5","article-title":"Observations on the 17 D virus vaccine against yellow fever, applied by cutaneous scarification [in Spanish]","volume":"5","author":"Groot","year":"1965"},{"key":"ref7","series-title":"Rev Panam Salud Publica","first-page":"115","article-title":"Effectiveness of the yellow fever vaccine 17D: an epidemiologic evaluation in health services [in Portuguese]","volume":"2","author":"Guerra","year":"1997"},{"key":"ref8","series-title":"J Med Virol","first-page":"159","article-title":"Development of viremia and humoral and cellular parameters of immune activation after vaccination with yellow fever virus strain 17D: a model of human flavivirus infection","volume":"56","author":"Reinhardt","year":"1998"},{"key":"ref9","series-title":"Am J Trop Med Hyg","first-page":"533","article-title":"Comparative safety and 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J Trop Med Hyg","first-page":"189","article-title":"Randomized, double-blind, phase III, pivotal field trial of the comparative immunogenicity, safety, and tolerability of two yellow fever 17D vaccines (Arilvax and YF-VAX) in healthy infants and children in Peru","volume":"72","author":"Belmusto-Worn","year":"2005"},{"key":"ref14","series-title":"Am J Trop Med Hyg","first-page":"339","article-title":"Immunogenicity and safety of BERNA-YF compared with two other 17D yellow fever vaccines in a phase 3 clinical trial","volume":"72","author":"Pfister","year":"2005"},{"key":"ref15","series-title":"Vaccine","first-page":"1421","article-title":"The effects of yellow fever immunization (17DD) inadvertently used in early pregnancy during a mass campaign in Brazil","volume":"24","author":"Suzano","year":"2006"},{"key":"ref16","series-title":"Am J Trop Med Hyg","first-page":"739","article-title":"Description of a prospective 17DD yellow fever vaccine cohort in Recife, 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Vaccine","year":"2015"},{"key":"ref21","series-title":"Lancet","first-page":"1599","article-title":"Yellow fever vaccine supply: a possible solution","volume":"387","author":"Monath","year":"2016"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/6\/article-p1435.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/6\/article-p1435.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/6\/article-p1435.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:50:28Z","timestamp":1723067428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/6\/article-p1435.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,7]]},"references-count":21,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.16-0401","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,7]]}}}