{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:40:05Z","timestamp":1723074005975},"reference-count":32,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,8]]},"abstract":"<jats:p>Coinfection with visceral leishmaniasis (VL) and human immunodeficiency virus (HIV) leads to frequent treatment failure, relapse, and death. In this retrospective analysis from eastern India (2005\u20132015), our primary objective was to ascertain the protective efficacy of secondary prophylaxis with monthly amphotericin B (AmB) given in patients with HIV\u2013VL coinfection toward reducing relapse and mortality rates. The secondary objective was to compare clinical features, laboratory findings, and treatment outcomes in HIV\u2013VL patients in contrast to VL monoinfection. Overall, 53 cases of HIV\u2013VL and 460 cases of VL monoinfection were identified after excluding incomplete records. Initial cure rate was 96.23% in HIV\u2013VL (27 received liposomal AmB and 26 AmB deoxycholate). All patients with initial cure (<jats:italic>N<\/jats:italic> = 51) were given antiretroviral therapy. Secondary prophylaxis (<jats:italic>N<\/jats:italic> = 27) was provided with monthly 1 mg\/kg AmB (15 liposomal, 12 deoxycholate). No relapse or death was noted within 6 months in the secondary prophylaxis group (relapse: none versus 18\/24 [75%]; mortality: none versus 11\/24 [45.8%]; <jats:italic>P<\/jats:italic> &lt; 0.001 for both). Secondary prophylaxis remained the sole significant predictor against death in multivariate Cox regression model (hazard ratio = 0.09 [95% confidence interval = 0.03\u20130.31]; <jats:italic>P<\/jats:italic> &lt; 0.001). HIV\u2013VL patients had higher 6-month relapse rate, less relapse-free 12-month survival, and higher mortality (<jats:italic>P<\/jats:italic> &lt; 0.001 each) than VL monoinfection. In conclusion, it appears from this study that secondary prophylaxis with monthly AmB might be effective in preventing relapse and mortality in HIV\u2013VL.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0432","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T03:00:16Z","timestamp":1479870016000},"page":"285-291","source":"Crossref","is-referenced-by-count":8,"title":["Protective Efficacy of Secondary Prophylaxis Against Visceral Leishmaniasis in Human Immunodeficiency Virus Coinfected Patients Over the Past 10 Years in Eastern India"],"prefix":"10.4269","volume":"96","author":[{"given":"Rama P.","family":"Goswami","sequence":"first","affiliation":[{"name":"Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudra P.","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institution of Post Graduate Medical Education and Research, Kolkata, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayan","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogiraj","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehebubar","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santanu K.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"PLoS One","first-page":"e35671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012"},{"key":"ref2","series-title":"Trop Med Int Health","first-page":"899","article-title":"Serious underreporting of visceral leishmaniasis through passive case reporting in Bihar, India","volume":"11","author":"Singh","year":"2006"},{"year":"2014","series-title":"National Roadmap for Kala-Azar Elimination in India","author":"Directorate of National Vector Borne Disease Control Programme","key":"ref3"},{"year":"2014","series-title":"State Fact Sheets","author":"National AIDS Control Organization","key":"ref4"},{"year":"2014","series-title":"The Gap Report","author":"UN Joint Programme on HIV\/AIDS (UNAIDS)","key":"ref5"},{"key":"ref6","series-title":"Front Immunol","first-page":"80","article-title":"T helper1\/T helper2 cells and resistance\/susceptibility to Leishmania infection: is this paradigm still relevant?","volume":"3","author":"Alexander","year":"2012"},{"key":"ref7","series-title":"PLoS Pathog","first-page":"e1002635","article-title":"Leishmania induces survival, proliferation and elevated cellular dNTP levels in human monocytes promoting acceleration of HIV co-infection","volume":"8","author":"Mock","year":"2012"},{"key":"ref8","series-title":"Curr Opin Infect Dis","first-page":"1","article-title":"Clinical aspects of visceral leishmaniasis in HIV infection","volume":"26","author":"Jarvis","year":"2013"},{"key":"ref9","series-title":"Clin Microbiol Rev","first-page":"334","article-title":"The relationship between leishmaniasis and AIDS: the second 10 years","volume":"21","author":"Alvar","year":"2008"},{"key":"ref10","series-title":"PLoS Negl Trop Dis","first-page":"e3053","article-title":"Visceral leishmaniasis and HIV co-infection in Bihar, India: long-term effectiveness and treatment outcomes with liposomal amphotericin B (AmBisome)","volume":"8","author":"Burza","year":"2014"},{"key":"ref11","series-title":"PLoS Negl Trop Dis","first-page":"e2195","article-title":"Efficacy of anti-Leishmania therapy in visceral leishmaniasis among HIV infected patients: a systematic review with indirect comparison","volume":"7","author":"Cota","year":"2013"},{"key":"ref12","series-title":"Am J Trop Med Hyg","first-page":"93","article-title":"Short-course treatment regimen of Indian visceral leishmaniasis with an Indian liposomal amphotericin B preparation (Fungisome\u2122)","volume":"94","author":"Goswami","year":"2016"},{"key":"ref13","series-title":"J Acquir Immune Defic Syndr","first-page":"115","article-title":"Visceral leishmaniasis and HIV coinfection in Bihar, India","volume":"32","author":"Sinha","year":"2003"},{"key":"ref14","series-title":"J Acquir Immune Defic Syndr","first-page":"572","article-title":"Kala-azar (visceral leishmaniasis) and HIV coinfection in Bihar, India: is this combination increasing?","volume":"32","author":"Thakur","year":"2003"},{"key":"ref15","series-title":"J Med Microbiol","first-page":"919","article-title":"Visceral leishmaniasis\/human immunodeficiency virus co-infection in India: the focus of two epidemics","volume":"55","author":"Mathur","year":"2006"},{"key":"ref16","series-title":"Clin Infect Dis","first-page":"552","article-title":"HIV and visceral leishmaniasis coinfection in Bihar, India: an underrecognized and underdiagnosed threat against elimination","volume":"59","author":"Burza","year":"2014"},{"key":"ref17","series-title":"J Assoc Physicians India","first-page":"759","article-title":"K39 strip test: easy, reliable and cost-effective field diagnosis for visceral leishmaniasis in India","volume":"51","author":"Goswami","year":"2003"},{"key":"ref18","series-title":"J Postgrad Med","first-page":"180","article-title":"Testing urine samples with rK39 strip as the simplest non-invasive field diagnosis for visceral leishmaniasis: an early report from eastern India","volume":"58","author":"Goswami","year":"2012"},{"key":"ref19","series-title":"J Assoc Physicians India","first-page":"154","article-title":"Utility of K39 strip test in visceral leishmaniasis (VL) and HIV co-infected patients: an early report from eastern India","volume":"55","author":"Goswami","year":"2007"},{"key":"ref20","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"798","article-title":"Prospective evaluation and follow-up of European patients with visceral leishmaniasis and HIV-1 coinfection in the era of highly active antiretroviral therapy","volume":"19","author":"Villanueva","year":"2000"},{"key":"ref21","series-title":"J Antimicrob Chemother","first-page":"837","article-title":"Efficacy of liposomal amphotericin B for secondary prophylaxis of visceral leishmaniasis in HIV-infected patients","volume":"60","author":"Molina","year":"2007"},{"key":"ref22","series-title":"AIDS","first-page":"2946","article-title":"Discontinuation of secondary anti-Leishmania prophylaxis in HIV-infected patients who have responded to highly active antiretroviral therapy","volume":"14","author":"Berenguer","year":"2000"},{"key":"ref23","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"202","article-title":"Relapsing visceral leishmaniasis in HIV-infected patients undergoing successful protease inhibitor therapy","volume":"20","author":"Casado","year":"2001"},{"key":"ref24","series-title":"PLoS Negl Trop Dis","first-page":"e1153","article-title":"Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review","volume":"5","author":"Cota","year":"2011"},{"key":"ref25","series-title":"Am J Med","first-page":"496","article-title":"Prophylaxis of visceral leishmaniasis in human immunodeficiency virus-infected patients","volume":"100","author":"Ribera","year":"1996"},{"key":"ref26","series-title":"Medicine (Baltimore)","first-page":"54","article-title":"Visceral leishmaniasis in HIV-infected and non-HIV-infected patients: a comparative study","volume":"80","author":"Pintado","year":"2001"},{"key":"ref27","series-title":"J Clin Microbiol","first-page":"5080","article-title":"Real-time PCR assay for clinical management of human immunodeficiency virus-infected patients with visceral leishmaniasis","volume":"41","author":"Bossolasco","year":"2003"},{"key":"ref28","series-title":"J Antimicrob Chemother","first-page":"540","article-title":"Amphotericin B lipid complex versus no treatment in the secondary prophylaxis of visceral leishmaniasis in HIV-infected patients","volume":"53","author":"L\u00f3pez-V\u00e9lez","year":"2004"},{"key":"ref29","series-title":"Med Interna","first-page":"506","article-title":"The clinical and evolutional characteristics of visceral leishmaniasis in patients with HIV infection","volume":"14","author":"Delgado Fern\u00e1ndez","year":"1997"},{"key":"ref30","series-title":"PLoS Negl Trop Dis","first-page":"e0004087","article-title":"Use of pentamidine as secondary prophylaxis to prevent visceral leishmaniasis relapse in HIV infected patients, the first twelve months of a prospective cohort study","volume":"9","author":"Diro","year":"2015"},{"key":"ref31","series-title":"Am J Trop Med Hyg","first-page":"543","article-title":"Who is a typical patient with visceral leishmaniasis? Characterizing the demographic and nutritional profile of patients in Brazil, east Africa, and south Asia","volume":"84","author":"Harhay","year":"2011"},{"key":"ref32","series-title":"Clin Infect Dis","first-page":"1255","article-title":"Combination treatment for visceral leishmaniasis patients coinfected with human immunodeficiency virus in India","volume":"61","author":"Mahajan","year":"2015"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/96\/2\/article-p285.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/96\/2\/article-p285.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/96\/2\/article-p285.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:43:12Z","timestamp":1723070592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/96\/2\/article-p285.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,8]]},"references-count":32,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.16-0432","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2017,2,8]]}}}