{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:51:50Z","timestamp":1792713110927,"version":"4.5.0"},"reference-count":35,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,2]]},"abstract":"<jats:p>\n                    Previous experimental studies have demonstrated that a number of mosquito-borne flavivirus pathogens are vertically transmitted in their insect vectors, providing a mechanism for these arboviruses to persist during adverse climatic conditions or in the absence of a susceptible vertebrate host. In this study, designed to test whether Zika virus (ZIKV) could be vertically transmitted, female\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    and\n                    <jats:italic>Aedes albopictus<\/jats:italic>\n                    were injected with ZIKV, and their F\n                    <jats:sub>1<\/jats:sub>\n                    adult progeny were tested for ZIKV infection. Six of 69\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    pools, comprised of a total of 1,738 F\n                    <jats:sub>1<\/jats:sub>\n                    adults, yielded ZIKV upon culture, giving a minimum filial infection rate of 1:290. In contrast, none of 803 F\n                    <jats:sub>1<\/jats:sub>\n                    <jats:italic>Ae. albopictus<\/jats:italic>\n                    adults (32 pools) yielded ZIKV. The MFIR for\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    was comparable to MFIRs reported for other flaviviruses in mosquitoes, including dengue, Japanese encephalitis, yellow fever, West Nile, and St. Louis encephalitis viruses. The results suggest that vertical transmission may provide a potential mechanism for the virus to survive during adverse conditions.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.16-0448","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T22:43:08Z","timestamp":1472510588000},"page":"1169-1173","source":"Crossref","is-referenced-by-count":172,"title":["Vertical Transmission of Zika Virus in Aedes aegypti Mosquitoes"],"prefix":"10.4269","volume":"95","author":[{"given":"Saravanan","family":"Thangamani","sequence":"first","affiliation":[{"name":"Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Guzman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Tesh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Clin Microbiol Rev","first-page":"487","article-title":"Zika 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