{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T15:27:46Z","timestamp":1767108466141},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,2]]},"abstract":"<jats:p>Praziquantel is the mainstay of treatment of Schistosomiasis, which affects at least 262 million people worldwide. It is also used in the treatment of other trematode as well as cestode infections, with few safe and effective alternatives. It is generally well tolerated and allergic reactions are rare. In this report, we present a case of schistosomiasis with a history of a hypersensitivity reaction to praziquantel. Skin-prick and intradermal testing were performed, followed by treatment through rapid desensitization. This protocol may be of value to those patients requiring praziquantel treatment with a history of IgE-mediated allergy to the drug.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0462","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T02:43:08Z","timestamp":1472524988000},"page":"1041-1043","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of Schistosomiasis in a Patient Allergic to Praziquantel: A Desensitization and Treatment Protocol"],"prefix":"10.4269","volume":"95","author":[{"given":"Trupti A.","family":"Patel","sequence":"first","affiliation":[{"name":"Hospital for Tropical Diseases, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Lukawska","sequence":"additional","affiliation":[{"name":"Royal National Throat, Nose and Ear Hospital, University College London Hospital, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Rowe","sequence":"additional","affiliation":[{"name":"Enys Road Surgery, Eastbourne, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin L.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Manson's Tropical Diseases","article-title":"Schistosomiasis","author":"Bustinduy","year":"2013"},{"key":"ref2","series-title":"Parasite Immunol","first-page":"163","article-title":"Immunopathogenesis of human schistosomiasis","volume":"31","author":"Burke","year":"2009"},{"key":"ref3","series-title":"Lancet","first-page":"2253","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014"},{"key":"ref4","series-title":"Med Res 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leukaemia","volume":"123","author":"Soyer","year":"2009"},{"key":"ref18","series-title":"J Allergy Clin Immunol","first-page":"574","article-title":"Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases","volume":"122","author":"Castells","year":"2008"},{"key":"ref19","series-title":"Cancer Immunol Immunother","first-page":"1575","article-title":"Hypersensitivity to antineoplastic agents: mechanisms and treatment with rapid desensitization","volume":"61","author":"Castells","year":"2012"}],"container-title":["The American Society of Tropical Medicine and 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