{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:37:06Z","timestamp":1775536626160,"version":"3.50.1"},"reference-count":30,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,8]]},"abstract":"<jats:p>Malaria serology through assaying for IgG against <jats:italic>Plasmodium<\/jats:italic> spp. antigens provides evidence into the infection history for an individual. The multiplex bead assay (MBA) allows for detection of IgG against multiple <jats:italic>Plasmodium<\/jats:italic> spp., and can be especially useful in many regions where <jats:italic>Plasmodium falciparum<\/jats:italic> is of primary clinical focus, but other species are co-endemic. Dried blood spots were collected from 805 Malian children attending 42 elementary schools in the regions of Mopti, Sikasso, Koulikoro, and Bamako capital district, and IgG assayed by MBA. As southern Mali is known to be holoendemic for <jats:italic>P. falciparum<\/jats:italic>, merozoite surface protein 1 19-kDa subunit (MSP-1<jats:sub>42<\/jats:sub>) and apical membrane antigen 1 (AMA-1) antigens were included for serology against this parasite. Responses to these antigens both provided high estimates for lifetime exposure, with 730 (90%) children with IgG antibodies for MSP-1<jats:sub>42<\/jats:sub>, 737 (91%) for AMA-1, and 773 (96%) positive for either or both. Also included was the antigen <jats:italic>Plasmodium vivax<\/jats:italic> MSP-1<jats:sub>19<\/jats:sub>, against which 140 (17.4%) children were found to have antibodies. Increases in antibody titers with older age were clearly seen with the <jats:italic>P. falciparum<\/jats:italic> antigens, but not with the <jats:italic>P. vivax<\/jats:italic> antigen, likely indicating more of a sporadic, rather than sustained transmission for this species. The MBA provides effective opportunities to evaluate malaria transmission through serological analysis for multiple <jats:italic>Plasmodium<\/jats:italic> species.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0476","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T03:00:40Z","timestamp":1480388440000},"page":"312-318","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of Immunoglobulin G Responses to Plasmodium falciparum and Plasmodium vivax in Malian School Children Using Multiplex Bead Assay"],"prefix":"10.4269","volume":"96","author":[{"given":"Eric","family":"Rogier","sequence":"first","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delynn M.","family":"Moss","sequence":"additional","affiliation":[{"name":"Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna N.","family":"Chard","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Trinies","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seydou","family":"Doumbia","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, Faculty of Medicine and Odontostomatology, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Lammie","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Adv Parasitol","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-407826-0.00002-3","article-title":"Red blood cell polymorphism and susceptibility to Plasmodium vivax","volume":"81","author":"Zimmerman","year":"2013"},{"key":"ref2","series-title":"Achieving the Malaria MDG Target: Malaria 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