{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:08:53Z","timestamp":1777349333622,"version":"3.51.4"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Visceral leishmaniasis (VL) is a vector-borne disease widespread in the Mediterranean basin, including Cyprus. During the last decades no cases were notified from northern Cyprus, but herein three cases of VL (female: 2, male: 1, median age: 24.6 months) diagnosed during their hospital admission between January 2011 and December 2012 are reported. Diagnosis was based on clinical findings; 1 \u2265 1\/64 titer positivity of immunofluorescence antibodies, <jats:italic>Leishmania<\/jats:italic> amastigotes in Giemsa-stained slides of bone marrow, as well as molecular identification confirmed that in all three the infecting pathogen was <jats:italic>Leishmania infantum<\/jats:italic>. Fever, splenomegaly, and hepatomegaly were the typical clinical findings. First-line treatment with liposomal amphotericin B (AmBisome<jats:sup>\u00ae<\/jats:sup>; intravenous, 3 mg\/kg) on days 1\u20135, followed by the same on days 10 and 21 yielded a successful outcome with no relapse in all cases. These confirmed VL cases found within 2 years demonstrate the presence of VL on the island.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0511","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T03:29:34Z","timestamp":1475551774000},"page":"1386-1388","source":"Crossref","is-referenced-by-count":7,"title":["Pediatric Visceral Leishmaniasis Caused by Leishmania infantum in Northern Cyprus"],"prefix":"10.4269","volume":"95","author":[{"given":"Ayse","family":"Sayili","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Dr. Burhan Nalbantoglu Governmental Hospital, Nicosia, Cyprus."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysegul Taylan","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Clinic Microbiology, Faculty of Medicine, Near East University, Nicosia, Cyprus."},{"name":"Department of Medical Microbiology, Faculty of Medicine, Hitit University, Corum, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk D. F. H.","family":"Schallig","sequence":"additional","affiliation":[{"name":"Parasitology Unit, Department of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Acta Trop","first-page":"43","article-title":"Leishmaniasis in Turkey","volume":"84","author":"Ok","year":"2002"},{"key":"ref2","series-title":"Lancet Infect Dis","first-page":"76","article-title":"Leishmania donovani leishmaniasis in Cyprus","volume":"9","author":"Antoniou","year":"2009"},{"key":"ref3","series-title":"Am J Trop Med Hyg","first-page":"441","article-title":"Leishmaniases and the Cyprus paradox","volume":"82","author":"Mazeris","year":"2010"},{"key":"ref4","series-title":"Parasitol Int","first-page":"131","article-title":"The infection risk of visceral leishmaniasis among household members of active 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region, Turkey [in Turkish]","volume":"44","author":"Oztoprak","year":"2010"},{"key":"ref18","series-title":"Leishmaniasis Fact Sheet","author":"World Health Organization","year":"2016"},{"key":"ref19","series-title":"Turkiye Parazitol Derg","first-page":"259","article-title":"Visceral leishmaniasis in 13 pediatric patients in Turkey: treatment experience [in Turkish]","volume":"33","author":"Arik Yilmaz","year":"2009"},{"key":"ref20","series-title":"Nat Rev Microbiol","first-page":"873","article-title":"Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?","volume":"5","author":"Chappuis","year":"2007"}],"container-title":["The American Society of Tropical Medicine and 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