{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:25:15Z","timestamp":1770485115135,"version":"3.49.0"},"reference-count":34,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,3]]},"abstract":"<jats:p><jats:italic>Staphylococcus aureus<\/jats:italic> infection is a persistent threat in resource-restricted settings in southeast Asia but informative data about this disease remain limited. We analyzed characteristics, management, and predictors of outcome in severely septic patients with community-onset <jats:italic>S. aureus<\/jats:italic> infection in northeast Thailand. We performed a prospective, multicenter observational cohort study of community-onset <jats:italic>S. aureus<\/jats:italic> sepsis in four referral hospitals recruiting patients at least 14 years of age admitted between March 2010 and December 2013. One hundred and nineteen patients with severe staphylococcal sepsis were enrolled. Diabetes was the most common underlying condition. Methicillin-resistant infection was rare. Twenty-eight-day mortality was 20%. Ninety-two percent of patients received appropriate antibiotic therapy and 82% were administered intravenous fluids on the first hospital day, although only 14% were managed in an intensive care unit (ICU). On univariable analysis, clinical variables at enrollment significantly associated with death at 28 days were coagulopathy or respiratory failure. Plasma interleukin (IL)-8 concentration alone accurately predicted mortality (area under the receiver operating curve = 0.82, 95% confidence interval = 0.73\u20130.90). In multivariable analysis, addition of IL-8 concentration to a mortality prediction model containing clinical variables further improved the predictive ability of the model. We conclude that severe staphylococcal sepsis in northeast Thailand causes significant mortality. Diabetes is a common preexisting condition and most patients are managed outside the ICU even if they receive vasoactive\/inotropic agents or mechanical ventilation. While clinical factors apparent on presentation including coagulopathy and respiratory failure predict death, plasma IL-8 improves this prediction.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0606","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T02:05:25Z","timestamp":1486433125000},"page":"1042-1049","source":"Crossref","is-referenced-by-count":7,"title":["Patient Characteristics, Management, and Predictors of Outcome from Severe Community-Onset Staphylococcal Sepsis in Northeast Thailand: A Prospective Multicenter Study"],"prefix":"10.4269","volume":"96","author":[{"given":"T. Eoin","family":"West","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington."},{"name":"International Respiratory and Severe Illness Center, University of Washington, Seattle, Washington."},{"name":"Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanthiwa","family":"Wikraiphat","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarunporn","family":"Tandhavanant","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pitchayanant","family":"Ariyaprasert","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pornpan","family":"Suntornsut","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawna","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weera","family":"Mahavanakul","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramot","family":"Srisamang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunchai","family":"Phiphitaporn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Udon Thani Regional Hospital, Udon Thani, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jirasak","family":"Anukunananchai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Khon Kaen Regional Hospital, Khon Kaen, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ploenchan","family":"Chetchotisakd","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon J.","family":"Peacock","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"London School of Hygiene and Tropical Medicine, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narisara","family":"Chantratita","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Lancet Infect Dis","first-page":"130","article-title":"Staphylococcus aureus disease and drug resistance in resource-limited countries in south and east Asia","volume":"9","author":"Nickerson","year":"2009"},{"key":"ref2","series-title":"PLoS One","first-page":"e59775","article-title":"Bloodstream infection among adults in Phnom Penh, Cambodia: key pathogens and resistance patterns","volume":"8","author":"Vlieghe","year":"2013"},{"key":"ref3","series-title":"Pediatr Infect Dis J","first-page":"e272","article-title":"Pediatric bloodstream infections in Cambodia, 2007 to 2011","volume":"32","author":"Stoesser","year":"2013"},{"key":"ref4","series-title":"J Trop Pediatr","first-page":"10","article-title":"Epidemiology of bacteremia in young hospitalized infants in Vientiane, Laos, 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