{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:53:11Z","timestamp":1774263191018,"version":"3.50.1"},"reference-count":64,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,8]]},"abstract":"<jats:p>Toll-like receptors (TLRs) are recognized as fundamental contributors to the immune system function against infections. Hepatitis C virus (HCV) infection represents a global health problem especially in Egypt having the highest HCV prevalence worldwide where HCV infection is a continuing epidemic. The aim of the present study was to investigate the possible association between genetic variation in TLR-3 and TLR-9 and HCV infection and hepatic fibrosis in chronic HCV-positive Egyptian patients. The present study included 100 na\u00efve chronic HCV-positive patients and 100 age- and sex-matched healthy controls. Genotyping of TLR-3 (_7 C\/A [rs3775296]), TLR-3 (c.1377C\/T [rs3775290]) and TLR-9 (1237T\/C [rs5743836]) were done by polymerase chain reaction restriction fragment length polymorphism technique. Frequency of polymorphic genotypes in TLR-3 (_7 C\/A), TLR-3 (c.1377C\/T) and TLR-9 (1237T\/C) were not significantly different between studied HCV-positive patients and controls with <jats:italic>P<\/jats:italic> values 0.121, 0.112, and 0.683, respectively. TLR-3 c.1377 T-allele was associated with advanced stage of hepatic fibrosis (<jats:italic>P<\/jats:italic> = 0.003).<\/jats:p>","DOI":"10.4269\/ajtmh.16-0644","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T01:50:41Z","timestamp":1484617841000},"page":"720-726","source":"Crossref","is-referenced-by-count":19,"title":["Association of Toll-Like Receptor 3 and Toll-Like Receptor 9 Single Nucleotide Polymorphisms with Hepatitis C Virus Infection and Hepatic Fibrosis in Egyptian Patients"],"prefix":"10.4269","volume":"96","author":[{"given":"Rania A.","family":"Zayed","sequence":"first","affiliation":[{"name":"Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia","family":"Omran","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepato-gastroentrology, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doha A.","family":"Mokhtar","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zinab","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepato-gastroentrology, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameera","family":"Ezzat","sequence":"additional","affiliation":[{"name":"Community Medicine Department, National Liver Institute, Menofia University, Menofia, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Specialized Liver Unit, Kasr Alainy Hospital, Cairo University, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamiaa","family":"Mobarak","sequence":"additional","affiliation":[{"name":"National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam","family":"El-Sweesy","sequence":"additional","affiliation":[{"name":"Tropical Medicine Department, Cairo Fatemic Hospital, Ministry of Health, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada","family":"Emam","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, National Institute of Neuromotor System, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Egypt Demographic and Health Survey 2008","author":"El-Zanaty","year":"2009"},{"key":"ref2","series-title":"Semin Liver Dis","first-page":"104","article-title":"Immunopathogenesis: role of innate and adaptive 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