{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:11:33Z","timestamp":1761217893834},"reference-count":26,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,11]]},"abstract":"<jats:p>Neurocysticercosis (NCC) has been associated with hippocampal atrophy, but the prevalence and pathogenic mechanisms implicated in this relationship are unknown. Using a population-based, case\u2013control study design, residents in a rural village (Atahualpa) aged \u2265 40 years with calcified NCC were identified as cases and paired to NCC-free individuals (control subjects) matched by age, sex, and level of education. Cases and control subjects underwent magnetic resonance imaging for hippocampal rating according to the Scheltens' scale for medial temporal atrophy and were interviewed to identify those with a clinical seizure disorder. The prevalence of hippocampal atrophy was compared between cases and control subjects by the use of the McNemar's test for correlated proportions. Seventy-five individuals with calcified NCC and their matched control subjects were included in the analysis. Hippocampal atrophy was noted in 26 (34.7%) cases and nine (12%) control subjects (odds ratio: 4.4; 95% confidence interval: 1.6\u201314.9, <jats:italic>P<\/jats:italic> &lt; 0.0021). Stratification of pairs according to tertiles of age revealed an age-related trend in this association, which became significant only in those aged \u2265 68 years (<jats:italic>P<\/jats:italic> = 0.027). Only five cases and one control had recurrent seizures (<jats:italic>P<\/jats:italic> = 0.221); three of these five cases had hippocampal atrophy, and the single control subject had normal hippocampi. This study confirms an association between NCC and hippocampal atrophy, and shows that this association is stronger in older age groups. This suggests that NCC-related hippocampal atrophy takes a long time to develop.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0689","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T03:30:31Z","timestamp":1479180631000},"page":"243-248","source":"Crossref","is-referenced-by-count":18,"title":["The Association Between Neurocysticercosis and Hippocampal Atrophy is Related to Age"],"prefix":"10.4269","volume":"96","author":[{"given":"Oscar H.","family":"Del Brutto","sequence":"first","affiliation":[{"name":"School of Medicine, Universidad Esp\u00edritu Santo\u2013Ecuador, Guayaquil, Ecuador."},{"name":"Department of Neurological Sciences, Hospital-Cl\u00ednica Kennedy, Guayaquil, Ecuador."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoum P.","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, Illinois."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perla","family":"Salgado","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor J.","family":"Del Brutto","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, Illinois."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Zambrano","sequence":"additional","affiliation":[{"name":"Atahualpa Project, Community Center, Atahualpa, Ecuador."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Lama","sequence":"additional","affiliation":[{"name":"Imaging Department, Hospital-Cl\u00ednica Kennedy, Guayaquil, Ecuador."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor H.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Center for Global Health, Tumbes, Per\u00fa."},{"name":"Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa."},{"name":"Cysticercosis Unit, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Per\u00fa."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Epilepsy: A Comprehensive Textbook","first-page":"2479","article-title":"Mesial temporal lobe epilepsy with hippocampal sclerosis","author":"Engel","year":"2008"},{"key":"ref2","series-title":"Curr Neurol Neurosci Rep","first-page":"67","article-title":"Update on hippocampal sclerosis","volume":"15","author":"Dutras","year":"2015"},{"key":"ref3","series-title":"Seizure","first-page":"340","article-title":"MRI evidence of mesial temporal sclerosis in subjects without 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