{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:32:40Z","timestamp":1791567160629,"version":"4.3.4"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Eosinophilia is a common laboratory finding in helminth infections but whether it is suggestive of neurocysticercosis (NCC) is controversial and inadequately studied. We determined the presence of eosinophilia (\u2265 500 eosinophils\/mm<jats:sup>3<\/jats:sup>) at clinical presentation in 72 patients with a proven or probable diagnosis of NCC and who had not received corticosteroids within 2 weeks of evaluation and complete blood count. Only two persons whose last possible endemic exposures to NCC were 7 and 6 years earlier had eosinophilia of 500 eosinophils\/mm<jats:sup>3<\/jats:sup> and both had a positive antibody serology to strongyloidiasis. In the one subject where a follow-up assessment was possible, the eosinophilia resolved. The likely cause for eosinophilia in both was strongyloidiasis. Therefore, none of the subjects with newly diagnosed NCC had significant eosinophilia. Eosinophilia in newly diagnosed symptomatic NCC subjects who had remote exposure is unusual and should prompt a search for another process or infection.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0701","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T20:13:13Z","timestamp":1476821593000},"page":"1432-1434","source":"Crossref","is-referenced-by-count":5,"title":["The Lack of Association of Eosinophilia and Neurocysticercosis at Clinical Presentation: A Retrospective Analysis of Cases Seen at the National Institutes of Health, 1985\u20132015"],"prefix":"10.4269","volume":"95","author":[{"given":"JeanAnne M.","family":"Ware","sequence":"first","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore E.","family":"Nash","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Immunol Allergy Clin North Am","first-page":"493","article-title":"Eosinophilia in infectious diseases","volume":"35","author":"O'Connell","year":"2015"},{"key":"ref2","series-title":"Lancet Neurol","first-page":"1202","article-title":"Clinical symptoms, diagnosis, and treatment of neurocysticercosis","volume":"13","author":"Garcia","year":"2014"},{"key":"ref3","series-title":"Cysticercosis: An Analysis and Follow Up of 450 Cases","first-page":"1","author":"Dixon","year":"1961"},{"key":"ref4","series-title":"Medicine (Baltimore)","first-page":"341","article-title":"Cerebral cysticercosis in San Diego. A report of 23 cases and a review of the literature","volume":"61","author":"Loo","year":"1982"},{"key":"ref5","series-title":"Pathog Glob Health","first-page":"299","article-title":"Diagnostic criteria for neurocysticercosis, revisited","volume":"106","author":"Del Brutto","year":"2012"},{"key":"ref6","series-title":"Clin Infect Dis","first-page":"407","article-title":"Diagnostic significance of blood eosinophilia in returning travelers","volume":"34","author":"Schulte","year":"2002"},{"key":"ref7","series-title":"J Infect Dis","first-page":"309","article-title":"Eosinophilia in southeast Asian refugees: evaluation at a referral center","volume":"155","author":"Nutman","year":"1987"},{"key":"ref8","series-title":"Ann Trop Med Parasitol","first-page":"249","article-title":"Eosinophilia as a marker for chronic strongyloidiasis\u2014use of a serum ELISA test to detect asymptomatic cases","volume":"83","author":"Gill","year":"1989"},{"key":"ref9","series-title":"Curr Infect Dis Rep","first-page":"256","article-title":"Imported strongyloidiasis: epidemiology, presentations, and treatment","volume":"14","author":"Buonfrate","year":"2012"},{"key":"ref10","series-title":"Am J Trop Med Hyg","first-page":"1088","article-title":"High rate of strongyloidosis infection, out of endemic area, in patients with eosinophilia and without risk of exogenous reinfections","volume":"82","author":"Repetto","year":"2010"},{"key":"ref11","series-title":"Basic Clinical Parasitology","author":"Neva","year":"1994"},{"key":"ref12","series-title":"Trans Am Neurol Assoc","first-page":"263","article-title":"Thirty-five verified cases of cysticercosis of the brain","volume":"56","author":"Trelles","year":"1952"},{"key":"ref13","series-title":"J Infect Dis","first-page":"659","article-title":"Factors in the pathogenesis of acute schistosomiasis mansoni","volume":"139","author":"Hiatt","year":"1979"},{"key":"ref14","series-title":"Acta Trop","first-page":"1","article-title":"Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"Brunetti","year":"2010"},{"key":"ref15","series-title":"Brain","first-page":"597","article-title":"Disseminated cysticercosis. New observations, including CT scan findings and experience with treatment by praziquantel","volume":"111","author":"Wadia","year":"1988"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/6\/article-p1432.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/6\/article-p1432.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/95\/6\/article-p1432.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:50:44Z","timestamp":1723067444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/95\/6\/article-p1432.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,7]]},"references-count":15,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.16-0701","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,7]]}}}