{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:56:47Z","timestamp":1760551007243},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,8]]},"abstract":"<jats:p>Nontyphoidal <jats:italic>Salmonella<\/jats:italic> infections can result in bacteremia. This study was undertaken to determine the predictive factors for bacteremia in children aged less than 16 years. Medical data were collected for every child with positive nontyphoidal <jats:italic>Salmonella<\/jats:italic> cultures in blood or stools at the University hospital of Martinique, French West Indies, between January 2005 and December 2015. Among 454 patients, 333 were included; 156 cases had confirmed bacteremia, and 177 were included as control group with nontyphoidal <jats:italic>Salmonella<\/jats:italic> only isolated in stools. Age at diagnosis, delay before consulting, prematurity, immunosuppression, or hyperthermic seizures were not significantly associated with bacteremia. C-reactive protein was higher in cases of bacteremia (<jats:italic>P<\/jats:italic> = 0.01); however, after adjusting to the threshold of 30 mg\/L, there was no longer any difference. There were also significant relations for electrolytes such as hyponatremia (odds ratio (OR) = 2.08 [95% CI = 1.31\u20133.95]; <jats:italic>P<\/jats:italic> &lt; 0.01), high urea level (OR = 0.53 [95% CI = 0.32\u20130.88], <jats:italic>P<\/jats:italic> &lt; 0.01). The infecting serotype was the most discriminant risk factor (<jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22124<\/jats:sup>). Among 28 serotypes isolated between 2005 and 2015, <jats:italic>Salmonella panama<\/jats:italic> was the most common serotype: 122 strains (78.2%) were isolated from bacteremic patients versus 60 (33.9%) from nonbacteremic patients (<jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22124<\/jats:sup>). <jats:italic>Salmonella panama<\/jats:italic> was the most important risk factor for bacteremia (OR = 7.37 [95% CI = 3.18\u201317.1], <jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22124<\/jats:sup>) even after multivariate analysis (OR = 13.09 [95% CI = 5.42\u201331.59], <jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22124<\/jats:sup>). After adjusting for bacteremia, <jats:italic>S. panama<\/jats:italic> was associated with a significantly higher body temperature than other <jats:italic>Salmonella<\/jats:italic>: 39\u00b0C (standard deviation [SD] = 0.92) versus 38.2\u00b0C [SD = 1.1], linear regression <jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22123<\/jats:sup>. Children with <jats:italic>Salmonella<\/jats:italic> serotype panama infection were at higher risk of bacteremia than children infected with other <jats:italic>Salmonella<\/jats:italic> serotypes.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0840","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T07:01:07Z","timestamp":1575961267000},"page":"58-62","source":"Crossref","is-referenced-by-count":5,"title":["Risk Factors for Nontyphi Salmonella Bacteremia Over 10 Years in Fort-de-France, Martinique, West Indies"],"prefix":"10.4269","volume":"102","author":[{"given":"Arnaud","family":"Buteux","sequence":"first","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Centre Hospitalier Universitaire de Martinique, Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Nacher","sequence":"additional","affiliation":[{"name":"EA 3593 Ecosyst\u00e8mes Amazoniens et Pathologie Tropicale, Universit\u00e9 de la Guyane, Cayenne, France;"},{"name":"INSERM CIC1424 Centre d\u2019Investigation Clinique Antilles Guyane, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia","family":"Merat","sequence":"additional","affiliation":[{"name":"Service de Parasitologie et Mycologie, Centre Hospitalier Universitaire de Nantes, Nantes, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"EA 3593 Ecosyst\u00e8mes Amazoniens et Pathologie Tropicale, Universit\u00e9 de la Guyane, Cayenne, France;"},{"name":"Service de Maladies Infectieuses et Tropicale, Centre Hospitalier Universitaire de Martinique, Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Roze","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicale, Centre Hospitalier Universitaire de Martinique, Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Cabi\u00e9","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicale, Centre Hospitalier Universitaire de Martinique, Fort-de-France, France;"},{"name":"INSERM CIC1424 Centre d\u2019Investigation Clinique Antilles Guyane, Centre Hospitalier Andr\u00e9e Rosemon, Cayenne, France;"},{"name":"EA 4537 Maladies Infectieuses et Tropicales dans la Cara\u00efbe, Universit\u00e9 des Antilles, Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Olive","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Centre Hospitalier Universitaire de Martinique, Fort-de-France, France;"},{"name":"EA 4537 Maladies Infectieuses et Tropicales dans la Cara\u00efbe, Universit\u00e9 des Antilles, Pointe-\u00e0-Pitre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Emerg Infect Dis","first-page":"941","article-title":"Global burden of invasive nontyphoidal Salmonella disease, 2010","volume":"21","author":"Ao","year":"2015"},{"key":"b2","series-title":"Clin Infect Dis Off Publ Infect Dis Soc Am.","first-page":"606","article-title":"Invasive non-yphi Salmonella disease in Africa","volume":"49","author":"Morpeth","year":"2009"},{"key":"b3","series-title":"Clin Infect Dis","first-page":"263","article-title":"Nontyphoidal salmonellosis","volume":"32","author":"Acheson","year":"2001"},{"key":"b4","series-title":"Antimicrob Agents Chemother","first-page":"1148","article-title":"Antimicrobial resistance among invasive nontyphoidal Salmonella enterica isolates in the United States: national antimicrobial resistance monitoring system, 1996\u20132007","volume":"55","author":"Crump","year":"2011"},{"key":"b5","series-title":"Lancet","first-page":"2489","article-title":"Invasive non-typhoidal Salmonella disease: an emerging and neglected tropical disease in Africa","volume":"379","author":"Feasey","year":"2012"},{"key":"b6","series-title":"J Natl Med Assoc","first-page":"219","article-title":"Meningitis caused by Salmonella panama in infants","volume":"98","author":"Choudhury","year":"2006"},{"key":"b7","series-title":"Clin Microbiol Infect","first-page":"651","article-title":"Non-typhi Salmonella gastroenteritis in children presenting to the emergency department: characteristics of patients with associated bacteraemia","volume":"11","author":"Bar-Meir","year":"2005"},{"author":"WHO","key":"b8"},{"key":"b10","series-title":"Med Sci Monit Int Med J Exp Clin Res","first-page":"CR255","article-title":"C reactive protein (CRP) as a predictor for true bacteremia in children","volume":"14","author":"Shaoul","year":"2008"},{"key":"b11","series-title":"Infect Dis","first-page":"147","article-title":"Nontyphoidal Salmonella infection in children: relation to bacteremia, age, and infecting serotype","volume":"48","author":"Asmar","year":"2016"},{"key":"b12","series-title":"Clin Infect Dis","first-page":"S325","article-title":"Salmonella bacteremia among children in central and northwest Nigeria, 2008\u20132015","volume":"61","author":"Obaro","year":"2015"},{"key":"b13","series-title":"Infection","first-page":"285","article-title":"Characteristics of non-typhi Salmonella gastroenteritis associated with bacteremia in infants and young children","volume":"40","author":"Shkalim","year":"2012"},{"key":"b14","series-title":"Clin Infect Dis","first-page":"S339","article-title":"Invasive Salmonella infections among children from rural Mozambique, 2001\u20132014","volume":"61","author":"Mandomando","year":"2015"},{"key":"b15","series-title":"BMC Microbiol","first-page":"101","article-title":"Characterisation of community acquired non-typhoidal Salmonella from bacteraemia and diarrhoeal infections in children admitted to hospital in Nairobi, Kenya","volume":"6","author":"Kariuki","year":"2006"},{"key":"b16","series-title":"Clin Infect Dis","first-page":"S346","article-title":"Invasive Salmonella infections at multiple surveillance sites in the democratic Republic of the Congo, 2011\u20132014","volume":"61","author":"Kalonji","year":"2015"},{"key":"b17","series-title":"Clin Microbiol Rev","first-page":"901","article-title":"Epidemiology, clinical presentation, laboratory diagnosis, antimicrobial resistance, and antimicrobial management of invasive Salmonella infections","volume":"28","author":"Crump","year":"2015"},{"key":"b18","series-title":"Epidemiol Infect","first-page":"1023","article-title":"Blood invasiveness of Salmonella enterica as a function of age and serotype","volume":"132","author":"Weinberger","year":"2004"},{"year":"2016","author":"Institut Pasteur","key":"b19"},{"key":"b20","series-title":"Clin Infect Dis","first-page":"S354","article-title":"Salmonella infections in the Gambia, 2005\u20132015","volume":"61","author":"Kwambana-Adams","year":"2015"},{"key":"b21","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"290","article-title":"Analysis of risk factors for bacteremia in children with nontyphoidal Salmonella gastroenteritis","volume":"21","author":"Yang","year":"2002"},{"key":"b22","series-title":"J Microbiol Immunol Infect","first-page":"234","article-title":"Change of serotype pattern of group D non-typhoidal Salmonella isolated from pediatric patients in southern Taiwan","volume":"40","author":"Tsai","year":"2007"},{"key":"b23","series-title":"J Travel Med","first-page":"460","article-title":"Salmonella panama and acute respiratory distress syndrome in a traveler taking a proton pump inhibitor","volume":"15","author":"Heysell","year":"2008"},{"key":"b24","series-title":"J Microbiol Immunol Infect","first-page":"507","article-title":"Genotyping and antimicrobial susceptibility of Salmonella enterica serotype Panama isolated in Taiwan","volume":"41","author":"Lee","year":"2008"},{"key":"b25"}],"container-title":["The American Journal of Tropical Medicine and 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