{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:12:21Z","timestamp":1785525141576,"version":"3.56.0"},"reference-count":39,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,12]]},"abstract":"<jats:p>Northwestern Argentina is endemic for soil-transmitted helminths, and annual deworming programs are carried out in prioritized areas. High prevalence of <jats:italic>Strongyloides stercoralis<\/jats:italic> was reported in this area; therefore, control programs including ivermectin are being evaluated. The NIE-enzyme linked immunosorbent assay (ELISA) was used for this purpose. In this community trial, two groups of patients, classified according to housing and living conditions were evaluated. Simultaneous with baseline survey, Group 1 was moved to new households with access to improved water and sanitation facilities (W and S), where deworming (MDA, massive drug administration) took place within 1 month; whereas Group 2 received MDA but remained living with unimproved W and S. The mean time interval between baseline and the follow-up was 331 days for Group 1 and 508 for Group 2. Anti-NIE levels were measured for each individual before and after interventions and follow-up optical density (OD) ratios were calculated to quantify the variation. A significant decrease of the anti-NIE levels between baseline and follow-up was observed in both groups. Nonetheless, the number of patients that achieved the cure criteria (OD ratio &lt; 0.6) was higher in Group 1 than Group 2 with values of 72.7% (24\/33) and 45.0% (18\/40), respectively (<jats:italic>P<\/jats:italic> = 0.0197). Our results support the conclusion that a combined intervention including deworming and improvements in life conditions is more effective, in terms of the proportion of subjects cured than deworming alone. Furthermore, we found that NIE-ELISA is a useful test for assessing the response to treatment and to evaluate the outcome of control intervention programs.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0857","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T07:00:11Z","timestamp":1491894011000},"page":"166-172","source":"Crossref","is-referenced-by-count":25,"title":["Serologic Monitoring of Public Health Interventions against Strongyloides stercoralis"],"prefix":"10.4269","volume":"97","author":[{"given":"Paola","family":"Vargas","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad Nacional de Salta, Sede Regional Or\u00e1n, Salta, Argentina;"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro J.","family":"Krolewiecki","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad Nacional de Salta, Sede Regional Or\u00e1n, Salta, Argentina;"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Echaz\u00fa","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad Nacional de Salta, Sede Regional Or\u00e1n, Salta, Argentina;"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Juarez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad Nacional de Salta, Sede Regional Or\u00e1n, Salta, Argentina;"},{"name":"Fundaci\u00f3n Mundo Sano, Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Cajal","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose F.","family":"Gil","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad Nacional de Salta, Sede Regional Or\u00e1n, Salta, Argentina;"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Caro","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad Nacional de Salta, Sede Regional Or\u00e1n, Salta, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Nasser","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad Nacional de Salta, Sede Regional Or\u00e1n, Salta, Argentina;"},{"name":"C\u00e1tedra de Qu\u00edmica Biol\u00f3gica, Universidad Nacional de Salta (UNSa), Salta, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lammie","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n O.","family":"Cimino","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones de Enfermedades Tropicales (IIET), Universidad Nacional de Salta, Sede Regional Or\u00e1n, Salta, Argentina;"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Med(Buenos Aires)","first-page":"29","article-title":"Geohelmintiasis en la Argentina una Revisi\u00f3n Sistem\u00e1tica","volume":"74","author":"Socias","year":"2014"},{"key":"ref2","series-title":"The Soil Transmitted Helminth Infections","first-page":"366","author":"World Health Organization","year":"2011"},{"key":"ref3","series-title":"Trans R Soc Trop Med Hyg","first-page":"967","article-title":"Strongyloidiasis: the most neglected of the neglected tropical diseases?","volume":"103","author":"Olsen","year":"2009"},{"key":"ref4","series-title":"PLoS Negl Trop Dis","first-page":"e2214","article-title":"Strongyloides stercoralis: a plea for action","volume":"7","author":"Bisoffi","year":"2013"},{"key":"ref5","series-title":"PLoS Negl Trop Dis","first-page":"e0004898","article-title":"StrongNet: an International network to improve diagnostics and access to 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