{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:40:16Z","timestamp":1781840416339,"version":"3.54.5"},"reference-count":11,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,3]]},"abstract":"<jats:p>The etiologic agent of yaws, <jats:italic>Treponema pallidum<\/jats:italic> subsp. <jats:italic>pertenue<\/jats:italic>, causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Although a multinational eradication campaign with mass administration of intramuscular benzathine benzylpenicillin in the 1950s greatly reduced its global incidence, a resurgence of yaws has occurred since around 2000 in western and central Africa and the Pacific Islands. The finding that a single oral dose of azithromycin (30 mg\/kg) was as effective as benzathine benzylpenicillin prompted renewed interest by World Health Organization in 2012 toward eradication of this infection by 2020. We previously reported the excellent response to benzathine benzylpenicillin therapy for yaws osteoperiostitis. Herein, we document a confirmed case of yaws with osteoperiostitis successfully treated with single-dose azithromycin and discuss the pathology of yaws periostitis and comment on the implications of this in light of the new campaign toward yaws eradication.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0943","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T01:40:26Z","timestamp":1487036426000},"page":"1039-1041","source":"Crossref","is-referenced-by-count":3,"title":["Yaws Osteoperiostitis Treated with Single-Dose Azithromycin"],"prefix":"10.4269","volume":"96","author":[{"given":"Camila","family":"Gonz\u00e1lez-Beiras","sequence":"first","affiliation":[{"name":"Barcelona Institute for Global Health, Hospital Cl\u00ednic, University of Barcelona, Barcelona, Spain."},{"name":"Lisbon Institute of Hygiene and Tropical Medicine, Lisbon, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00ed","family":"Vall-Mayans","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health, Hospital Cl\u00ednic, University of Barcelona, Barcelona, Spain."},{"name":"STI Unit, University Hospital Vall d'Hebron, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Gonz\u00e1lez-Escalante","sequence":"additional","affiliation":[{"name":"Department of Imaging and Radiology, Complejo Hospitalario de Pontevedra, Pontevedra, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"McClymont","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sullivan Nicolaides Pathology, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sullivan Nicolaides Pathology, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Mitj\u00e0","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health, Hospital Cl\u00ednic, University of Barcelona, Barcelona, Spain."},{"name":"Lihir Medical Centre\u2013International SOS, Newcrest Mining, Lihir Island, Papua New Guinea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Lancet","first-page":"1","article-title":"Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study","volume":"14","author":"Mitj\u00e0","year":"2014"},{"key":"ref2","series-title":"Clin Microbiol Rev","first-page":"89","article-title":"The endemic treponematoses","volume":"27","author":"Giacani","year":"2014"},{"key":"ref3","series-title":"Clin Infect Dis","first-page":"771","article-title":"Osteoperiostitis in early yaws: case series and literature review","volume":"52","author":"Mitj\u00e0","year":"2011"},{"key":"ref4","series-title":"Clin Infect Dis","first-page":"1454","article-title":"History of syphilis","volume":"40","author":"Rothschild","year":"2005"},{"key":"ref5","series-title":"Clin Infect Dis","first-page":"1402","article-title":"Treponemal disease revisited: skeletal discriminators for yaws, bejel, and venereal syphilis","volume":"20","author":"Rothschild","year":"1995"},{"key":"ref6","series-title":"BMC Infect Dis","first-page":"347","article-title":"Osteitis in the dens of axis caused by Treponema pallidum","volume":"13","author":"Fabricius","year":"2013"},{"key":"ref7","series-title":"Br J Vener Dis","first-page":"256","article-title":"Bone lesions in early syphilis detected by bone scintigraphy","volume":"60","author":"Hansen","year":"1984"},{"key":"ref8","series-title":"Lancet","first-page":"342","article-title":"Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial","volume":"379","author":"Mitj\u00e0","year":"2012"},{"key":"ref9","series-title":"N Engl J Med","first-page":"703","article-title":"Mass treatment with single-dose azithromycin for yaws","volume":"372","author":"Mitj\u00e0","year":"2015"},{"key":"ref10","series-title":"Wkly Epidemiol Rec","first-page":"189","article-title":"Eradication of yaws: the Morges strategy","volume":"87","author":"World Health Organization","year":"2012"},{"key":"ref11","series-title":"Bull World Health Organ","first-page":"499","article-title":"Yaws eradication: past efforts and future perspectives","volume":"86","author":"Asiedu","year":"2008"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/96\/5\/article-p1039.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/96\/5\/article-p1039.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/96\/5\/article-p1039.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:28:20Z","timestamp":1723069700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/96\/5\/article-p1039.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":11,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.16-0943","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,3]]}}}