{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T17:03:15Z","timestamp":1756573395656},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,7]]},"abstract":"<jats:p>To compare diagnostic tests for onchocerciasis in a setting that has suppressed transmission, a randomized, age-stratified study was implemented in an area in Tanzania that had received 15 rounds of annual mass drug administration (MDA) with ivermectin. Study participants (<jats:italic>N<\/jats:italic> = 948) from 11 villages underwent a questionnaire, skin examination, skin snips, and blood draw. The burden of symptomatic disease was low. Ov-16 antibody rapid diagnostic test (RDT) results were positive in 38 (5.5%) participants, with 1 (0.5%), 1 (0.4%), and 2 (0.8%) in children aged 0\u20135, 6\u201310, and 11\u201315 years, respectively. Despite significant impact of MDA on transmission, the area would have failed to meet World Health Organization serologic criteria for stopping MDA if a full evaluation had been conducted. The specificity of the RDT, which is 97\u201398%, may result in the identification of a number of false positives that would exceed the current stop MDA threshold.<\/jats:p>","DOI":"10.4269\/ajtmh.16-0988","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T07:00:37Z","timestamp":1497337237000},"page":"673-676","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Onchocerciasis Transmission in Tanzania: Preliminary Rapid Field Results in the Tukuyu Focus, 2015"],"prefix":"10.4269","volume":"97","author":[{"given":"Heather N.","family":"Paulin","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Nshala","sequence":"additional","affiliation":[{"name":"Neglected Tropical Diseases Control Program, Dar es Salaam, Tanzania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akili","family":"Kalinga","sequence":"additional","affiliation":[{"name":"National Institute of Medical Research, Tukuyu Medical Research Centre, Tukuyu, Tanzania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Upendo","family":"Mwingira","sequence":"additional","affiliation":[{"name":"Neglected Tropical Diseases Control Program, Dar es Salaam, Tanzania;"},{"name":"National Institute of Medical Research, Neglected Tropical Diseases Control Program, Dar es Salaam, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Wiegand","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaliano","family":"Cama","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul T.","family":"Cantey","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"year":"2010","key":"b1"},{"key":"b2","series-title":"Wkly Epidemiol Rec","first-page":"505","article-title":"Progress report on the elimination of human onchocerciasis, 2015\u20132016","volume":"91","year":"2016"},{"key":"b3","series-title":"Clin Microbiol Rev","first-page":"459","article-title":"Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment","volume":"24","author":"Tamarozzi","year":"2011"},{"key":"b4","series-title":"Lancet Infect Dis","first-page":"310","article-title":"Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and 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