{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:36:03Z","timestamp":1778038563520,"version":"3.51.4"},"reference-count":28,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,12]]},"abstract":"<jats:p>Recent studies have demonstrated an association between congenital Zika virus (ZIKV) infection and microcephaly; however, to date, there have been no reports on the consequences of ZIKV infection on fetuses in twin pregnancies. Herein, we reported on the first case of a monochorionic diamniotic (MCDA) twin pregnancy having ZIKV-related microcephaly. Our findings suggested that, in an MCDA twin pregnancy, the ZIKV may cause infection in both fetuses, resulting in severe abnormalities in the central nervous system due to neural cell destruction and the disruption of the normal development processes of the brain. This case report and other similar twin cases may help to understand the pathogenesis and to confirm the etiology of ZIKV as a teratogenic microorganism.<\/jats:p>","DOI":"10.4269\/ajtmh.16-1021","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T07:00:13Z","timestamp":1491894013000},"page":"151-154","source":"Crossref","is-referenced-by-count":12,"title":["Case Report: Microcephaly in Twins due to the Zika Virus"],"prefix":"10.4269","volume":"97","author":[{"given":"Victor S.","family":"Santos","sequence":"first","affiliation":[{"name":"Federal University of Sergipe, Aracaju, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila J. G.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of Sergipe, Aracaju, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Q.","family":"Gurgel","sequence":"additional","affiliation":[{"name":"Federal University of Sergipe, Aracaju, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy R. R.","family":"Lima","sequence":"additional","affiliation":[{"name":"Federal University of Sergipe, Aracaju, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cliomar A.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratory, Aracaju, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo R. S.","family":"Martins-Filho","sequence":"additional","affiliation":[{"name":"Federal University of Sergipe, Aracaju, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"ref1","series-title":"Lancet","first-page":"621","article-title":"Microcephaly in Brazil: how to interpret reported numbers?","volume":"387","author":"Victora","year":"2016"},{"key":"ref2","series-title":"Mem Inst Oswaldo Cruz","first-page":"287","article-title":"Zika virus damages the human placental barrier and presents marked fetal neurotropism","volume":"111","author":"de Noronha","year":"2016"},{"key":"ref3","series-title":"Emerg Infect Dis","first-page":"405","article-title":"Zika Virus RNA replication and persistence in brain and placental tissue","volume":"23","author":"Bhatnagar","year":"2017"},{"key":"ref4","series-title":"N Engl J Med","first-page":"1981","article-title":"Zika virus and birth defects: reviewing the evidence for 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