{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:21:43Z","timestamp":1771456903061,"version":"3.50.1"},"reference-count":8,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,2]]},"abstract":"<jats:p>We investigated the in vitro activity of a novel fifth-generation cephalosporin\u2013tazobactam combination, ceftolozane\u2013tazobactam against <jats:italic>Burkholderia pseudomallei<\/jats:italic>, the etiological agent of melioidosis. Using both disc diffusion and minimum inhibitory concentration (MIC) strip techniques against 56 clinical isolates and an national collection of type cultures (NCTC) strain, the MIC to ceftolozane\u2013tazobactam was found to be between 0.75 and 4 mcg\/mL. The MIC50 was found to be 1.5 mcg\/mL and MIC90 was 2.0 mcg\/mL. This study provides initial evidence of ceftolozane\u2013tazobactam as a novel agent in the management of melioidosis.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0049","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:00:59Z","timestamp":1529996459000},"page":"281-282","source":"Crossref","is-referenced-by-count":4,"title":["Activity of Ceftolozane\u2013Tazobactam against Burkholderia pseudomallei"],"prefix":"10.4269","volume":"99","author":[{"given":"Andrew","family":"Slack","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Internal Medicine Department, Townsville Hospital, Townsville, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Parsonson","sequence":"additional","affiliation":[{"name":"Pathology Queensland, Townsville Hospital, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Cronin","sequence":"additional","affiliation":[{"name":"Pathology Queensland, Townsville Hospital, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Engler","sequence":"additional","affiliation":[{"name":"Pathology Queensland, Townsville Hospital, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Norton","sequence":"additional","affiliation":[{"name":"Pathology Queensland, Townsville Hospital, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Microbiol Rev","first-page":"383","article-title":"Melioidosis: epidemiology, pathophysiology, and management","volume":"18","author":"Cheng","year":"2005"},{"key":"b2","series-title":"Lancet","first-page":"1715","article-title":"Melioidosis","volume":"361","author":"White","year":"2003"},{"key":"b3","series-title":"Future Microbiol","first-page":"1389","article-title":"Mechanisms of antibiotic resistance in Burkholderia pseudomallei: implications for treatment of melioidosis","volume":"7","author":"Schweizer","year":"2012"},{"key":"b4","series-title":"Curr Opin Infect Dis","first-page":"554","article-title":"Melioidosis: advances in diagnosis and treatment","volume":"23","author":"Cheng","year":"2010"},{"key":"b5","series-title":"J Antimicrob Chemother","first-page":"2014","article-title":"Efficacy of ceftolozane\/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTIs) caused by levofloxacin-resistant pathogens: results from the ASPECT-cUTI trial","volume":"71","author":"Huntington","year":"2016"},{"key":"b6","series-title":"Clin Infect Dis","first-page":"1462","article-title":"Ceftolozane\/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI)","volume":"60","author":"Solomkin","year":"2015"},{"key":"b7","author":"FDA","year":"2014"},{"key":"b8","author":"EUCAST","year":"2017"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/2\/article-p281.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/2\/article-p281.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/2\/article-p281.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T12:49:28Z","timestamp":1722430168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/2\/article-p281.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,2]]},"references-count":8,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.17-0049","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,2]]}}}