{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:23:36Z","timestamp":1759742616805},"reference-count":28,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,2]]},"abstract":"<jats:p>Adult T-cell Leukemia\/Lymphoma (ATLL) is a sight- and life-threatening complication of human T-cell lymphotropic virus type 1 (HTLV-1) infection. Ophthalmic manifestations include uveitis, optic nerve oedema, retinal vasculitis, and lymphomatous infiltration. Orbital lesions are rare. We report the case of an orbital tumor revealing systemic ATLL in a 45-year-old Dominican patient who died despite treatment. Apart from late-grade cutaneous T-cell lymphoma, ATLL is the only T-lymphoma to develop in the orbit. Diagnosis is based on serologic evidence of HTLV-1 infection, cytology, and blood sample analysis. Biopsy is deemed necessary. Given the poor prognosis of ATLL and the worldwide presentation of HTLV-1, physicians should consider ATLL in the differential diagnosis of orbital malignant tumor and look for HTLV-1 infection in populations at risk.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0137","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T07:01:18Z","timestamp":1530601278000},"page":"435-438","source":"Crossref","is-referenced-by-count":8,"title":["Case Report: Orbital Tumor Revealing Adult T-Cell Leukemia\/Lymphoma Associated with Human T-Cell Lymphotropic Virus Type-1"],"prefix":"10.4269","volume":"99","author":[{"given":"Selim","family":"Far\u00e8s","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Martinique University Hospital, Martinique, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabih","family":"Hage","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Martinique University Hospital, Martinique, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Pegliasco","sequence":"additional","affiliation":[{"name":"Hematology Department, Martinique University Hospital, Martinique, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samy","family":"Chraibi","sequence":"additional","affiliation":[{"name":"Hematology Department, Martinique University Hospital, Martinique, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Merle","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Martinique University Hospital, Martinique, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Acquir Immune Defic Syndr Hum Retrovirol","first-page":"S191","article-title":"An HTLV-I\/II vaccine: from animal models to clinical trials?","volume":"13","author":"de Th\u00e9","year":"1996"},{"key":"b2","series-title":"Front Microbiol","first-page":"388","article-title":"Epidemiological aspects and world distribution of HTLV-1 infection","volume":"3","author":"Gessain","year":"2012"},{"key":"b3","series-title":"Jpn J Ophthalmol","first-page":"168","article-title":"Clinical features of HTLV-I associated uveitis determined in multicenter collaborative study. 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