{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:32:10Z","timestamp":1761823930212},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,8]]},"abstract":"<jats:p>Cryptococcal meningitis may have long-term morbidity and requires a permanent cerebrospinal fluid shunt. This study aimed to evaluate the risk factors and create a predictive model for permanent shunt treatment in cryptococcal meningitis patients. This was a retrospective analytical study conducted at Khon Kaen University. The study period was from January 2005 to December 2015. We enrolled all adult patients diagnosed with cryptococcal meningitis. Risk factors predictive for permanent shunting treatment were analyzed by multivariate logistic regression analysis. There were 341 patients diagnosed with cryptococcal meningitis. Of those, 64 patients (18.7%) were treated with permanent shunts. There were three independent factors associated with permanent shunt treatment. The presence of hydrocephalus had the highest adjusted odds ratio at 56.77. The resulting predictive model for permanent shunt treatment (y) is (\u22123.85) + (4.04 \u00d7 hydrocephalus) + (2.13 \u00d7 initial cerebrospinal fluid (CSF) opening pressure (OP) &gt; 25 cm H<jats:sub>2<\/jats:sub>O) + (1.87 \u00d7 non-human immune deficiency vrus (HIV)). In conclusion, non-HIV status, initial CSF OP greater than or equal to 25 cm H<jats:sub>2<\/jats:sub>O, and the presence of hydrocephalus are indicators of the future necessity for permanent shunt therapy.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0177","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T07:00:34Z","timestamp":1502780434000},"page":"1451-1453","source":"Crossref","is-referenced-by-count":10,"title":["Predictive Model for Permanent Shunting in Cryptococcal meningitis"],"prefix":"10.4269","volume":"97","author":[{"given":"Woralux","family":"Phusoongnern","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriluck","family":"Anunnatsiri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kittisak","family":"Sawanyawisuth","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand;"},{"name":"Research Center in Back, Neck Other Joint Pain and Human Performance (BNOJPH), Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Non-communicable Diseases Research Group, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amnat","family":"Kitkhuandee","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Expert Opin Pharmacother","first-page":"551","article-title":"Epidemiology and management of cryptococcal meningitis: developments and challenges","volume":"9","author":"Pukkila-Worley","year":"2008"},{"key":"b2","series-title":"Trans Am Clin Climatol Assoc","first-page":"61","article-title":"Cryptococcal infections in non-HIV-infected patients","volume":"124","author":"Pappas","year":"2013"},{"key":"b3","series-title":"J Clin Neurosci","first-page":"1175","article-title":"Ventriculoperitoneal shunt for intracranial hypertension in cryptococcal meningitis without hydrocephalus","volume":"19","author":"Petrou","year":"2012"},{"key":"b4","series-title":"Eur Rev Med Pharmacol Sci","first-page":"3801","article-title":"Clinical study of 23 pediatric patients with cryptococcosis","volume":"19","author":"Luo","year":"2015"},{"key":"b5","series-title":"Neurol J Southeast Asia","first-page":"45","article-title":"Cryptococcal meningitis in patients with non-HIV and HIV infection: a clinical study","volume":"2","author":"Tunlayadechanont","year":"1997"},{"key":"b6","series-title":"Clin Neurol Neurosurg","first-page":"156","article-title":"Evaluation of ventriculoperitoneal shunt in the treatment of intracranial hypertension in the patients with cryptococcal meningitis: a report of 12 cases","volume":"124","author":"Wang","year":"2014"},{"key":"b7","series-title":"Childs Nerv Syst","first-page":"1543","article-title":"Radiologic evaluation of pediatric hydrocephalus","volume":"27","author":"Dincer","year":"2011"},{"key":"b8","series-title":"J Neurol Neurosurg Psychiatry","first-page":"i17","article-title":"Hydrocephalus and shunts: what the neurologist should know","volume":"73","author":"Pople","year":"2002"},{"key":"b9","series-title":"J Neurosurg","first-page":"177","article-title":"Shunting in cryptococcal meningitis","volume":"125","author":"Cherian","year":"2016"},{"key":"b10","series-title":"Am J Med","first-page":"267","article-title":"Elevated cerebrospinal fluid pressures in patients with cryptococcal meningitis and acquired immunodeficiency syndrome","volume":"91","author":"Denning","year":"1991"},{"key":"b11","series-title":"AIDS","first-page":"701","article-title":"Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures","volume":"23","author":"Bicanic","year":"2009"},{"key":"b12","series-title":"Clin Infect Dis","first-page":"291","article-title":"Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America","volume":"50","author":"Perfect","year":"2010"},{"key":"b13","series-title":"Surg Neurol","first-page":"529","article-title":"The use of ventriculoperitoneal shunts for uncontrollable intracranial hypertension without ventriculomegally secondary to HIV-associated cryptococcal meningitis","volume":"63","author":"Woodworth","year":"2005"},{"key":"b14","series-title":"Clin Infect Dis","first-page":"673","article-title":"Shunt surgery for hydrocephalus complicating cryptococcal meningitis in human immunodeficiency virus negative patients","volume":"37","author":"Liliang","year":"2003"},{"key":"b15","series-title":"J Neurol Neurosurg Psychiatry","first-page":"330","article-title":"Cerebral cryptococcosis in Malaysia","volume":"39","author":"Richardson","year":"1976"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/97\/5\/article-p1451.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/97\/5\/article-p1451.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/97\/5\/article-p1451.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T16:49:16Z","timestamp":1722444556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/97\/5\/article-p1451.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,8]]},"references-count":15,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.17-0177","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2017,11,8]]}}}