{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T02:34:23Z","timestamp":1722738863934},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,8]]},"abstract":"<jats:p>To investigate the relationship between heart rate and temperature, we examined 493 febrile patients with documented disease. These patients were diagnosed serologically and analyzed retrospectively: 337 (68.4%) responded to fever with increased heart rate &lt; 10 beats\/minute\/\u00b0C (relative bradycardia [RB]), and 156 patients had a heart rate response \u2265 10 beats\/minute\/\u00b0C (general heart rate increase [GHRI]). The RB group had a higher median resting heart rate and lower heart rate at maximum temperature than the GHRI group. Despite differences in heart rate response, no significant differences were seen in clinical outcomes (acute kidney injury, systemic inflammatory response syndrome (SIRS), and death). We concluded that most patients with scrub typhus presented with RB. In scrub typhus infection, RB can be included as one of the clinical features for differential diagnosis from other infectious diseases.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0259","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T07:00:46Z","timestamp":1506409246000},"page":"1316-1318","source":"Crossref","is-referenced-by-count":2,"title":["Relative Bradycardia in Scrub Typhus"],"prefix":"10.4269","volume":"97","author":[{"given":"Lae Young","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University, Jeonju, Republic of Korea;"},{"name":"Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mir","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University, Jeonju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"Industrial Design, Chonbuk National University, Jeonju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Hee","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University, Jeonju, Republic of Korea;"},{"name":"Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Seop","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University, Jeonju, Republic of Korea;"},{"name":"Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung-Suk","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University, Jeonju, Republic of Korea;"},{"name":"Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Bull US Army Med Dep","first-page":"163","article-title":"Clinical survey of 86 cases of scrub typhus","volume":"5","author":"Agress","year":"1946"},{"key":"b2","series-title":"Clin Exp Immunol","first-page":"63","article-title":"Differential patterns of endothelial and leucocyte activation in \u2018typhus-like\u2019 illnesses in Laos and Thailand","volume":"153","author":"Paris","year":"2008"},{"key":"b3","series-title":"Southeast Asian J Trop Med Public Health","first-page":"503","article-title":"Electrocardiographic changes in scrub typhus patients","volume":"8","author":"Fang","year":"1977"},{"key":"b4","series-title":"Infect Chemother","first-page":"58","article-title":"Torsades de pointes by azithromycin in scrub typhus and review on cardiac manifestations of scrub typhus","volume":"40","author":"Lim","year":"2008"},{"key":"b5","series-title":"Australas Med J","first-page":"164","article-title":"Transient adrenal insufficiency and post-treatment bradycardia in scrub typhus - a case report","volume":"7","author":"Mookkappan","year":"2014"},{"key":"b6","series-title":"Am J Trop Med Hyg","first-page":"477","article-title":"Prevalence of relative bradycardia in Orientia tsutsugamushi infection","volume":"68","author":"Aronoff","year":"2003"},{"key":"b7","series-title":"J Assoc Physicians India","first-page":"30","article-title":"Clinical profile and complications of scrub typhus: hospital-based study in sub-himalayan region","volume":"64","author":"Kumar","year":"2016"},{"key":"b8","series-title":"East Afr Med J","first-page":"360","article-title":"Clinical picture of scrub typhus in East African troops on the Burma front","volume":"22","author":"Deshmukh","year":"1945"},{"key":"b9","series-title":"Bull US Army Med Dep","first-page":"163","article-title":"Clinical survey of 86 cases of scrub typhus","volume":"5","author":"Agress","year":"1946"},{"key":"b10","series-title":"Trop Geogr Med","first-page":"143","article-title":"Clinical observations of scrub typhus on Penghu (the Pescadores Islands)","volume":"27","author":"Fang","year":"1975"},{"key":"b11","series-title":"Am J Trop Med Hyg","first-page":"542","article-title":"Usefulness of nested PCR for the diagnosis of scrub typhus in clinical practice: a prospective study","volume":"75","author":"Kim","year":"2006"},{"key":"b12","series-title":"Clin Infect Dis","first-page":"1329","article-title":"A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus","volume":"39","author":"Kim","year":"2004"},{"key":"b13","series-title":"Postgrad Med","first-page":"69","article-title":"Atypical pneumonias: clinical and extrapulmonary features of Chlamydia, mycoplasma, and legionella infections","volume":"93","author":"Johnson","year":"1993"},{"key":"b14","series-title":"Clin Microbiol Infect","first-page":"633","article-title":"The diagnostic significance of relative bradycardia in infectious disease","volume":"6","author":"Cunha","year":"2000"},{"key":"b15","series-title":"Clin Infect Dis","first-page":"1218","article-title":"Relative bradycardia and lymphopenia in patients with babesiosis","volume":"26","author":"Kim","year":"1998"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/97\/5\/article-p1316.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/97\/5\/article-p1316.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/97\/5\/article-p1316.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T16:45:39Z","timestamp":1722444339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/97\/5\/article-p1316.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,8]]},"references-count":15,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.17-0259","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2017,11,8]]}}}