{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:59:23Z","timestamp":1787507963741,"version":"build-2736575974"},"reference-count":32,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,10]]},"abstract":"<jats:p>\n                    The relationship between hepatitis B virus (HBV) infection, severity of liver disease, frequency of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection, and degree of gastric lesions was not yet fully investigated in Egyptian patients. The present work was performed on 100 Egyptian patients with HBV from the National Hepatology and Tropical Medicine Institute and 70 healthy volunteers as control group. The participants were subjected to full medical history taking, clinical examination, and laboratory investigations. All patients were positive for HBV surface antigen (HBV sAg), HBV DNA, and negative for hepatitis C virus antibodies. The severity of the liver disease was assessed using Child\u2013Pugh scoring system. Screening of all participants for\n                    <jats:italic>H. pylori<\/jats:italic>\n                    Ag in stool was performed. Biopsy specimens were taken from the gastric lesions of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected patients for histopathological examination. The mean age of the patients and control group were 34.9 and 33.4 years, respectively. The levels of the liver enzymes were statistically higher in HBV patients than the control group.\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    Ag in stool was detected in 45.7% of the control group, and a higher percentage (60%) was detected in the patients group. Chronic gastritis with glandular atrophy and metaplasia was found in 15.6% of patients of Child\u2013Pugh A, 70% of Child\u2013Pugh B, and 100% of Child\u2013Pugh C. It could be concluded that the prognosis of the liver disease significantly influences the severity of the gastric pathology in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.17-0291","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T01:03:05Z","timestamp":1516323785000},"page":"221-226","source":"Crossref","is-referenced-by-count":12,"title":["Association between Severity of Liver Disease, Frequency of Helicobacter pylori Infection, and Degree of Gastric Lesion in Egyptian Patients with Hepatitis B Virus Infection"],"prefix":"10.4269","volume":"98","author":[{"given":"Amal A.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, National Hepatology and Tropical Medicine Research institute, Cairo, Egypt;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal A.","family":"Elshimy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, New Giza University, Cairo, Egypt;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir O.","family":"El Sadik","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, New Giza University, Cairo, Egypt;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ezzat","sequence":"additional","affiliation":[{"name":"Department of Microbiology, El Glaa Teaching Hospital, Cairo, Egypt;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Nasar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, El Sahel Teaching Hospital, Cairo, Egypt;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen S. M.","family":"Elshaer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy (Girls), Al Azhar University,Cairo, Egypt;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moataz M.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Ann Clin Lab Res","article-title":"Research advances on occult hepatitis B virus infection and its roles in digestive system tumor development: a new focus in cancer prevention","volume":"S1","author":"Shang","year":"2015"},{"key":"b2","series-title":"World J Hepatol","first-page":"64","article-title":"Occult hepatitis B virus infection among Egyptian blood donors","volume":"5","author":"Said","year":"2013"},{"key":"b3","series-title":"Arab J Gastroenterol","first-page":"35","article-title":"Hepatitis B, virus in the Arab world: where do we stand?","volume":"14","author":"Gasim","year":"2013"},{"key":"b4","series-title":"J Med Virol","first-page":"129","article-title":"Hepatitis B virus infection in upper and lower Egypt","volume":"15","author":"Sherif","year":"1985"},{"key":"b5","series-title":"Arch Dis Child","first-page":"1037","article-title":"Management of chronic hepatitis B infection","volume":"99","author":"Davison","year":"2014"},{"key":"b6","series-title":"Int J Prev Med","first-page":"S200","article-title":"Prevention and management of chronic hepatitis B","volume":"5","author":"Bhat","year":"2014"},{"key":"b7","series-title":"Int J Cancer","first-page":"690","article-title":"Epidemiology of hepatitis viruses among hepatocellular carcinoma cases and healthy people in Egypt: a systematic review and meta-analysis","volume":"124","author":"Lehman","year":"2009"},{"key":"b8","series-title":"Infect Agent Cancer","first-page":"35","article-title":"A review of the infection-associated cancers in North African countries","volume":"11","author":"Hussein","year":"2016"},{"key":"b9","series-title":"J Hepatol","first-page":"648","article-title":"Helicobacter pylori seroprevalence in hepatitis C virus positive patients with cirrhosis","volume":"33","author":"Pellicano","year":"2000"},{"key":"b10","series-title":"Gastroenterology","first-page":"1244","article-title":"Relationship between Helicobacter pylori eradication and gastric ulcer and duodenal ulcer reduced recurrence: a review","volume":"110","author":"Hopkins","year":"1996"},{"key":"b11","series-title":"Am J Biochem Biotechnol","first-page":"110","article-title":"The relation between Helicobacter pylori infection and hepatocellular carcinoma in Egyptian patients","volume":"11","author":"Serag","year":"2015"},{"key":"b12","series-title":"Life Sci J","first-page":"168","article-title":"Helicobacter pylori in Egyptian patients with HCV related liver cirrhosis and portal hypertensive gastropathy: prevalence and relation to disease severity","volume":"12","author":"Safwat","year":"2015"},{"key":"b13","series-title":"Eur J Gastroenterol Hepatol","first-page":"717","article-title":"Helicobacter pylori is a risk factor for peptic ulcer disease in cirrhotic patients. A meta-analysis","volume":"14","author":"Vergara","year":"2002"},{"key":"b14","series-title":"Methods Mol Biol","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-62703-005-2_23","article-title":"Innate immune responses to Helicobacter pylori infection: an overview","volume":"921","author":"Patel","year":"2012"},{"key":"b15","series-title":"Saudi J Gastroenterol","first-page":"95","article-title":"Does Helicobacter pylori affect portal hypertensive gastropathy?","volume":"13","author":"Al Mofleh","year":"2007"},{"key":"b16","series-title":"Gastroenterology","first-page":"181","article-title":"Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. The New Italian Endoscopic Club for the study and treatment of esophageal varices (NIEC)","volume":"119","author":"Primignani","year":"2000"},{"key":"b17","series-title":"Clin Mol Hepatol","first-page":"1","article-title":"Management of portal hypertensive gastropathy and other bleeding","volume":"20","author":"Chung","year":"2014"},{"key":"b18","series-title":"Am J Trop Med Hyg","first-page":"37","article-title":"Seroprevalence of Helicobacter pylori among Egyptian newborns and their mothers: a preliminary report","volume":"61","author":"Bassily","year":"1999"},{"key":"b19","series-title":"Public Health Nutr","first-page":"230","article-title":"Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth","volume":"11","author":"Mohammad","year":"2008"},{"key":"b20","series-title":"Egyptian Rheumatologist","first-page":"167","article-title":"Helicobacter pylori in Egyptian patients with fibromyalgia syndrome","volume":"35","author":"Olama","year":"2013"},{"key":"b21","series-title":"Clin Epidemiol","first-page":"4","article-title":"Helicobacter pylori and hepatitis C virus coinfection in Egyptian patients","volume":"2","author":"El-Masry","year":"2010"},{"key":"b22","series-title":"J Adv Res","first-page":"287","article-title":"Impact of Helicobacter pylori infection on liver fibrosis in Egyptian patients with chronic hepatitis C","volume":"3","author":"Ragheb","year":"2012"},{"key":"b23","series-title":"Donnish Journal of Biomedical Research","first-page":"13","article-title":"Effect of Helicobacter pylori on treatment of hepatitis C virus Egyptian patients","volume":"3","author":"Madkour","year":"2016"},{"key":"b24","series-title":"Br J Surg","first-page":"648","article-title":"Esophagus in bleeding oesophageal varices","volume":"60","author":"Pugh","year":"1973"},{"key":"b25","first-page":"55","author":"Petrie","year":"2005"},{"key":"b26","series-title":"Gastroenterol Res","first-page":"262","article-title":"Helicobacter pylori DNA in liver tissues from chronic hepatitis C Egyptian patients","volume":"4","author":"Mahmoud","year":"2011"},{"key":"b27","series-title":"Dig Dis Sci","first-page":"2024","article-title":"High prevalence of Helicobacter pylori in liver cirrhosis: relationship with clinical and endoscopic features and the risk of peptic ulcer","volume":"42","author":"Siringo","year":"1997"},{"key":"b28","series-title":"J Liaquat Uni Med Health Sci","first-page":"93","article-title":"Frequency of Helicobacter pylori among hepatic encephalopathic patients in liver cirrhosis","volume":"11","author":"Shaikh","year":"2012"},{"key":"b29","series-title":"Int J Infect Dis","first-page":"30","article-title":"Helicobacter pylori infection may increase the risk of progression of chronic hepatitis B disease among the Chinese population: a meta-analysis","volume":"50","author":"Wang","year":"2016"},{"key":"b30","series-title":"Br J Biomed Sci","first-page":"176","article-title":"Seroprevalenceof Helicobacter pylori infection in patients with hepatitisB","volume":"55","author":"Fan","year":"1998"},{"key":"b31","series-title":"W J Exp Biosci","first-page":"18","article-title":"Evaluation of anti-Helicobacter pylori antibodies level in sera of patients with chronic hepatitis B","volume":"3","author":"Abid","year":"2015"},{"key":"b32","series-title":"Ann Gastroenterol","first-page":"1","article-title":"Helicobacter pylori infection in patients with liver cirrhosis: prevalence and association with portal hypertensive gastropathy","volume":"26","author":"Abdul Sathar","year":"2013"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/98\/1\/article-p221.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/98\/1\/article-p221.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/98\/1\/article-p221.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T18:59:39Z","timestamp":1722452379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/98\/1\/article-p221.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,10]]},"references-count":32,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.17-0291","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,10]]}}}