{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:24:04Z","timestamp":1776212644697,"version":"3.50.1"},"reference-count":34,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,10]]},"abstract":"<jats:p><jats:italic>Trypanosoma cruzi<\/jats:italic>, the etiological agent of Chagas diseases, invades the cardiac tissue causing acute myocarditis and heart electrical disturbances. In <jats:italic>T. cruzi<\/jats:italic> invasion, the parasite induces [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> transients in the host cells, an essential phenomenon for invasion. To date, knowledge on the mechanism that elicits transients of [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> during the infection of cardiac myocytes has not been fully characterized. Pannexin1 (Panx1) channel are poorly selective channels found in all vertebrates that serve as a pathway for ATP release. In this article, we demonstrate that <jats:italic>T. cruzi<\/jats:italic> infection results in the opening of Panx1 channels in cardiac myocytes. We show that pharmacological blockade of Panx1 channels inhibits <jats:italic>T. cruzi<\/jats:italic>\u2013induced [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> transients and invasion in cardiac myocytes. Our results indicate that opening of Panx1 channels are required for <jats:italic>T. cruzi<\/jats:italic> invasion in cardiac myocytes, and we propose that targeting Panx1 channel could provide new potential therapeutic approaches to treat Chagas disease.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0293","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T10:15:05Z","timestamp":1510913705000},"page":"105-112","source":"Crossref","is-referenced-by-count":14,"title":["Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes"],"prefix":"10.4269","volume":"98","author":[{"given":"Iv\u00e1n","family":"Barr\u00eda","sequence":"first","affiliation":[{"name":"Experimental Physiology Laboratory (EPhyL), Antofagasta Institute, Universidad de Antofagasta, Antofagasta, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"G\u00fciza","sequence":"additional","affiliation":[{"name":"Experimental Physiology Laboratory (EPhyL), Antofagasta Institute, Universidad de Antofagasta, Antofagasta, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredi","family":"Cifuentes","sequence":"additional","affiliation":[{"name":"Experimental Physiology Laboratory (EPhyL), Antofagasta Institute, Universidad de Antofagasta, Antofagasta, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Zamorano","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, Department of Biomedicine, Universidad de Antofagasta, Antofagasta, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"S\u00e1ez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile;"},{"name":"Centro Interdisciplinario de Neurociencias de Valpara\u00edso, Valpara\u00edso, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Unit, Faculty of Health Sciences, Universidad de Antofagasta, Antofagasta, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L.","family":"Vega","sequence":"additional","affiliation":[{"name":"Experimental Physiology Laboratory (EPhyL), Antofagasta Institute, Universidad de Antofagasta, Antofagasta, Chile;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"1564","article-title":"Global burden of disease attributable to illicit drug use and dependence: findings from the Global Burden of Disease Study 2010","volume":"382","author":"Degenhardt","year":"2013"},{"key":"b2","series-title":"Front Immunol","first-page":"327","article-title":"Current understanding of the Trypanosoma cruzi-cardiomyocyte 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