{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:13:57Z","timestamp":1790205237029,"version":"4.1.0"},"reference-count":30,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,8]]},"abstract":"<jats:p>There is little published information on the epidemiology of neurological disorders in rural Central Africa, although the burden is considered to be substantial. This study aimed to investigate the pattern, etiology, and outcome of neurological disorders in children &gt; 5 years and adults admitted to the rural hospital of Mosango, province of Kwilu, Democratic Republic of Congo, with a focus on severe and treatable infections of the central nervous system (CNS). From September 2012 to January 2015, 351 consecutive patients hospitalized for recent and\/or ongoing neurological disorder were prospectively evaluated by a neurologist, subjected to a set of reference diagnostic tests in blood or cerebrospinal fluid, and followed-up for 3\u20136 months after discharge. No neuroimaging was available. Severe headache (199, 56.7%), gait\/walking disorders (97, 27.6%), epileptic seizure (87, 24.8%), and focal neurological deficit (86, 24.5%) were the predominant presentations, often in combination. Infections of the CNS were documented in 63 (17.9%) patients and mainly included bacterial meningitis and unspecified meningoencephalitis (33, 9.4%), second-stage human African trypanosomiasis (10, 2.8%), and human immunodeficiency virus (HIV)-related neurological disorders (10, 2.8%). Other focal\/systemic infections with neurological manifestations were diagnosed in an additional 60 (17.1%) cases. The leading noncommunicable conditions were epilepsy (61, 17.3%), psychiatric disorders (56, 16.0%), and cerebrovascular accident (23, 6.6%). Overall fatality rate was 8.2% (29\/351), but up to 23.8% for CNS infections. Sequelae were observed in 76 (21.6%) patients. Clinical presentations and etiologies of neurological disorders were very diverse in this rural Central African setting and caused considerable mortality and morbidity.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0375","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T07:00:28Z","timestamp":1502780428000},"page":"1454-1460","source":"Crossref","is-referenced-by-count":21,"title":["Clinical Spectrum, Etiology, and Outcome of Neurological Disorders in the Rural Hospital of Mosango, the Democratic Republic of Congo"],"prefix":"10.4269","volume":"97","author":[{"given":"Deby","family":"Mukendi","sequence":"first","affiliation":[{"name":"Institut National de Recherche Biom\u00e9dicale, Kinshasa, DR Congo;"},{"name":"Universit\u00e9 de Kinshasa, Kinshasa, DR Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Roger","family":"Lilo Kalo","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Biom\u00e9dicale, Kinshasa, DR Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Mpanya","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Biom\u00e9dicale, Kinshasa, DR Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Minikulu","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Biom\u00e9dicale, Kinshasa, DR Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharcisse","family":"Kayembe","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Kinshasa, Kinshasa, DR Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Lutumba","sequence":"additional","affiliation":[{"name":"Institut National de Recherche Biom\u00e9dicale, Kinshasa, DR Congo;"},{"name":"Universit\u00e9 de Kinshasa, Kinshasa, DR Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Barb\u00e9","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gillet","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium;"},{"name":"Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Van Loen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric P.","family":"Yansouni","sequence":"additional","affiliation":[{"name":"JD MacLean Centre for Tropical Diseases, McGill University Health Centre, Montreal, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Chappuis","sequence":"additional","affiliation":[{"name":"Division of Tropical and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Ravinetto","sequence":"additional","affiliation":[{"name":"Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristien","family":"Verdonck","sequence":"additional","affiliation":[{"name":"Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"Boelaert","sequence":"additional","affiliation":[{"name":"Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Technical University of Munich, Munich, Germany;"},{"name":"Centre for Global Health, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bottieau","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"2197","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990\u20132010: 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