{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:51:32Z","timestamp":1785549092242,"version":"3.56.0"},"reference-count":11,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,10]]},"abstract":"<jats:p><jats:italic>Rickettsia slovaca<\/jats:italic>, a spotted fever group rickettsial pathogen, causes a syndrome consisting of scalp eschar and neck lymphadenopathy following tick bite. We analyzed the histologic skin reaction in the eschar, showing a prominent eosinophilic infiltration, as well as the presence of B lymphocytes and CD4- and CD8-positive T cells. Examination of the serum cytokine responses over time demonstrated an initial proinflammatory cytokine elevation followed by normalization.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0392","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T07:00:37Z","timestamp":1508828437000},"page":"248-251","source":"Crossref","is-referenced-by-count":7,"title":["Histology and Serum Cytokine Responses in an Imported Rickettsia slovaca Infection, Germany"],"prefix":"10.4269","volume":"98","author":[{"given":"Dennis","family":"Tappe","sequence":"first","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Booken","sequence":"additional","affiliation":[{"name":"Dermatologikum Hamburg, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"B\u00f6er-Auer","sequence":"additional","affiliation":[{"name":"Dermatologikum Hamburg, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Rauch","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schmiedel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Reich","sequence":"additional","affiliation":[{"name":"Dermatologikum Hamburg, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Microbiol Rev","first-page":"657","article-title":"Update on tick-borne rickettsioses around the world: a geographic approach","volume":"26","author":"Parola","year":"2013"},{"key":"b2","series-title":"Emerg Infect Dis","first-page":"1105","article-title":"Rickettsia slovaca and R. raoultii in tick-borne rickettsioses","volume":"15","author":"Parola","year":"2009"},{"key":"b3","series-title":"Ticks Tick Borne Dis","first-page":"60","article-title":"High detection rate of Rickettsia africae in Amblyomma variegatum but low prevalence of anti-rickettsial antibodies in healthy pregnant women in Madagascar","volume":"7","author":"Keller","year":"2016"},{"key":"b4","series-title":"Int J Syst Bacteriol","first-page":"839","article-title":"Phylogenetic analysis of spotted fever group rickettsiae by study of the outer surface protein rOmpA","volume":"3","author":"Fournier","year":"1998"},{"key":"b5","series-title":"Int J Syst Bacteriol","first-page":"252","article-title":"Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae","volume":"47","author":"Roux","year":"1997"},{"key":"b6","series-title":"Emerg Infect Dis","first-page":"1332","article-title":"Histologic features and immunodetection of African tick-bite fever eschar","volume":"12","author":"Lepidi","year":"2006"},{"key":"b7","series-title":"J Infect Dis","first-page":"802","article-title":"Immunohistochemical evaluation of the cellular immune response to Rickettsia conorii in taches noires","volume":"155","author":"Herrero-Herrero","year":"1987"},{"key":"b8","series-title":"Virchows Arch A Pathol Anat Histopathol","first-page":"309","article-title":"The histology of \u201ctaches noires\u201d of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence","volume":"400","author":"Montenegro","year":"1983"},{"key":"b9","series-title":"J Infect","first-page":"33","article-title":"The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992\u20131997","volume":"42","author":"Vitale","year":"2001"},{"key":"b10","series-title":"J Infect Dis","first-page":"1332","article-title":"Systemic inflammatory responses in African tick-bite fever","volume":"187","author":"Jensenius","year":"2003"},{"key":"b11","series-title":"Future Microbiol","first-page":"323","article-title":"Host-cell interactions with pathogenic Rickettsia species","volume":"4","author":"Sahni","year":"2009"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/98\/1\/article-p248.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/98\/1\/article-p248.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/98\/1\/article-p248.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T17:07:58Z","timestamp":1722445678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/98\/1\/article-p248.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,10]]},"references-count":11,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.17-0392","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,10]]}}}