{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:45:20Z","timestamp":1783406720463,"version":"3.54.6"},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,6]]},"abstract":"<jats:p>Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by <jats:italic>Lacazia loboi<\/jats:italic>, an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Several weeks after return, he recalled pruritus and papular skin lesions on the left lower limb, subsequently evolving to a plaque-like lesion. Blastomycosis and cryptococcosis were hypothesized based on microscopic morphology of yeast-like bodies found in three consecutive biopsies, although fungal cultures were always negative. In 2016, exfoliative cytology and a biopsy specimen examination showed round yeast-like organisms (6\u201312 \u03bcm), isolated or in a chain, connected by short tubular projections fulfilling the morphologic diagnostic criteria of <jats:italic>Lacazia<\/jats:italic> spp. The microscopic diagnosis was confirmed by molecular identification.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0446","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T07:00:40Z","timestamp":1506409240000},"page":"1757-1760","source":"Crossref","is-referenced-by-count":11,"title":["Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela"],"prefix":"10.4269","volume":"97","author":[{"given":"Anna","family":"Beltrame","sequence":"first","affiliation":[{"name":"Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Danesi","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Farina","sequence":"additional","affiliation":[{"name":"Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, UOC Microbiologia e Virologia, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierantonio","family":"Orza","sequence":"additional","affiliation":[{"name":"Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Perandin","sequence":"additional","affiliation":[{"name":"Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Zanardello","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Rodari","sequence":"additional","affiliation":[{"name":"Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Staffolani","sequence":"additional","affiliation":[{"name":"Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeno","family":"Bisoffi","sequence":"additional","affiliation":[{"name":"Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Clin Microbiol","first-page":"2031","article-title":"Lacazia loboi gen. nov., comb. nov., the etiologic agent of lobomycosis","volume":"37","author":"Taborda","year":"1999"},{"key":"b2","series-title":"J Clin Microbiol","first-page":"309","article-title":"Phylogenetic analysis of Lacazia loboi places this previously uncharacterized pathogen within the dimorphic Onygenales","volume":"39","author":"Herr","year":"2001"},{"key":"b3","series-title":"Mycoses","first-page":"298","article-title":"Lobomycosis: an emerging disease in humans and delphinidae","volume":"55","author":"Paniz-Mondolfi","year":"2012"},{"key":"b4","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"273","article-title":"Ten years experience with Jorge Lobo\u2019s disease in the state of Acre, Amazon region, Brazil","volume":"52","author":"Woods","year":"2010"},{"key":"b5","series-title":"Br J Dermatol","first-page":"234","article-title":"Lobomycosis in African patients","volume":"159","author":"Al-Daraji","year":"2008"},{"key":"b6","series-title":"J Dermatol Case Rep","first-page":"65","article-title":"Lobomycosis: a case from southeastern Europe and review of the literature","volume":"6","author":"Papadavid","year":"2012"},{"key":"b7","series-title":"J Cutan Pathol","first-page":"5","article-title":"Lobomycosis. An electron microscopic, histochemical and immunologic study","volume":"3","author":"Bhawan","year":"1976"},{"key":"b8","series-title":"Int J Dermatol","first-page":"438","article-title":"Anergic cutaneous leishmaniasis versus lobomycosis","volume":"35","author":"Nalovic","year":"1996"},{"key":"b9","series-title":"Ned Tijdschr Geneeskd","first-page":"2746","article-title":"Imported skin diseases","volume":"142","author":"Cairo","year":"1998"},{"key":"b10","series-title":"Ann Pathol","first-page":"241","article-title":"Lobomycosis: a mycosis seldom observed in metropolitan France","volume":"20","author":"Saint-Blancard","year":"2000"},{"key":"b11","series-title":"J Clin Microbiol","first-page":"1283","article-title":"Report of the first human case of lobomycosis in the United States","volume":"38","author":"Burns","year":"2000"},{"key":"b12","series-title":"Hautarzt","first-page":"677","article-title":"Sucessful treatment with clofazimine and itraconazole in a 46 year old patient after 32 years duration of disease","volume":"53","author":"Fischer","year":"2002"},{"key":"b13","series-title":"Emerg Infect Dis","first-page":"715","article-title":"Human case of lobomycosis","volume":"10","author":"Elsayed","year":"2004"},{"key":"b14","series-title":"Ther Adv Infect Dis","first-page":"91","article-title":"Jorge Lobo\u2019s disease: a case of keloidal blastomycosis (lobomycosis) in a nonendemic area","volume":"2","author":"Arju","year":"2014"},{"key":"b15","author":"White","year":"1990"},{"key":"b16","series-title":"Int J Dermatol","first-page":"180","article-title":"Lobomycosis in Venezuela","volume":"46","author":"Paniz-Mondolfi","year":"2007"},{"key":"b17","series-title":"Ther Clin Risk Manag","first-page":"851","article-title":"Lobomycosis: epidemiology, clinical presentation, and management options","volume":"10","author":"Francesconi","year":"2014"},{"key":"b18","series-title":"Actas Dermosifiliogr","first-page":"816","article-title":"Cutaneous involvement in the deep mycoses: a review. 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