{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:18:04Z","timestamp":1772255884623,"version":"3.50.1"},"reference-count":39,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,6]]},"abstract":"<jats:p>Puncture, Aspiration, Injection of scolicidal agent, Re-aspiration is the most widely used percutaneous treatment of cystic echinococcosis (CE). Among its perceived risks is chemical sclerosing cholangitis, a serious complication due to the caustic effect of the scolicidal solution on the biliary tree, when a patent cystobiliary fistula occurs. To simplify the protocol, we decided to omit injection and reaspiration of the scolicidal agent and to implement a full course of albendazole (ABZ) therapy instead of the routine 1-month ABZ prophylaxis. We searched our databases for patients with CL (Cystic Lesion, suspected for CE), CE1, and CE3a cysts treated between October 2007 and January 2017 with percutaneous aspiration followed by at least 1 month of oral ABZ and with an ultrasound follow-up of at least 6 months. Fifteen patients matched our inclusion criteria. Follow-up ranged from 7 to 75 months. The oral ABZ course after the aspiration procedure ranged from 1 to 18 months. Eleven subjects (73.3%) had undergone a course of ABZ before the percutaneous procedure (min 15 days, max 16 months). Ten cysts (62.5%) had reached solidification (stage CE4) in 3 to 69 months. Four other cysts (26.7%) remained stable in stage CE3a, whereas two cysts (13.3%) reactivated to stage CE3b. Procedural perioperative complications occurred in 13.3% of patients, whereas complications during the follow-up occurred in 20% of patients. These proof-of-concept preliminary results are overall comparable with those reported in the literature for other percutaneous treatments, both in terms of response rate, relapse rate, and morbidity.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0468","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T03:00:40Z","timestamp":1506999640000},"page":"1818-1826","source":"Crossref","is-referenced-by-count":11,"title":["Preliminary Evaluation of Percutaneous Treatment of Echinococcal Cysts without Injection of Scolicidal Agent"],"prefix":"10.4269","volume":"97","author":[{"given":"Giovanni","family":"Firpo","sequence":"first","affiliation":[{"name":"WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambra","family":"Vola","sequence":"additional","affiliation":[{"name":"WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;"},{"name":"Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Lissandrin","sequence":"additional","affiliation":[{"name":"WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;"},{"name":"Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Tamarozzi","sequence":"additional","affiliation":[{"name":"WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;"},{"name":"Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Brunetti","sequence":"additional","affiliation":[{"name":"WHO-Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy;"},{"name":"Division of Infectious Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy;"},{"name":"Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS Negl Trop Dis","first-page":"e1146","article-title":"Cystic echinococcosis: chronic, complex, and still neglected","volume":"5","author":"Brunetti","year":"2011"},{"key":"b2","author":"Eckert","year":"2001"},{"key":"b3","series-title":"Radiographics","first-page":"795","article-title":"Hydatid disease: radiologic and pathologic features and complications","volume":"20","author":"Pedrosa","year":"2000"},{"key":"b4","series-title":"Infect Dis Clin North Am","first-page":"421","article-title":"Cestode infestations: hydatid disease and cysticercosis","volume":"26","author":"Brunetti","year":"2012"},{"key":"b5","series-title":"Acta Trop","first-page":"1","article-title":"Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"Brunetti","year":"2010"},{"key":"b6","series-title":"Radiology","first-page":"627","article-title":"Hepatic echinococcal cyst: successful percutaneous drainage","volume":"155","author":"Mueller","year":"1985"},{"key":"b7","series-title":"Invest Radiol","first-page":"121","article-title":"Percutaneous treatment of abdominal hydatid cysts with hypertonic saline and alcohol: an experimental study in sheep","volume":"28","author":"Akhan","year":"1993"},{"key":"b8","series-title":"Eur J Radiol","first-page":"76","article-title":"Percutaneous treatment of liver hydatid cysts","volume":"32","author":"Akhan","year":"1999"},{"key":"b9","series-title":"Tunis Med","first-page":"325","article-title":"Treatment of hepatic hydatid cyst in sheep by echographic puncture","volume":"64","author":"Ben Amor","year":"1986"},{"key":"b10","series-title":"Ann Parasitol Hum Comp","first-page":"689","article-title":"Trial therapy of inoperable abdominal hydatid cysts by puncture","volume":"61","author":"Ben Amor","year":"1986"},{"key":"b11","series-title":"Gastroenterology","first-page":"1366","article-title":"A new therapeutic approach for hydatid liver cysts. 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