{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:35:36Z","timestamp":1773815736060,"version":"3.50.1"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,10]]},"abstract":"<jats:p>Diagnosing extrapulmonary tuberculosis (EPTB) is challenging. Point-of-care ultrasound (POCUS) for human immunodeficiency virus (HIV)-associated EPTB is applied in sub-Saharan Africa. This study aimed at evaluating the applicability of POCUS for diagnosing EPTB in HIV-positive and HIV-negative presumptive tuberculosis (TB) patients in India, a country of moderate relative TB and HIV burden. Presumptive TB patients at Kasturba Hospital, Manipal, India, prospectively underwent POCUS evaluating for pericardial, pleural and ascitic effusion, abdominal lymphadenopathy, and hepatic and splenic microabscesses. Findings were correlated with TB category (confirmed TB, clinical TB, unlikely TB), HIV status, and discharge diagnoses. A total of 425 patients underwent POCUS; 81 (20%) were HIV-positive. POCUS findings were more common in HIV\/TB coinfected patients than in HIV-positive patients with unlikely TB (24\/40 (60%) versus 9\/41 (22%), <jats:italic>P<\/jats:italic> &lt; 0.001). Abdominal lymphadenopathy and splenic microabscesses were strongly associated with TB in HIV-positive patients (<jats:italic>P<\/jats:italic> = 0.002 and <jats:italic>P<\/jats:italic> = 0.001). POCUS findings did not correlate with TB in HIV-negative patients; a third of HIV-negative patients with unlikely TB and POCUS findings had cancer, another third other infectious diseases. Sonographic findings were common in HIV-positive and HIV-negative presumptive TB patients. POCUS was a useful bedside test for the detection of HIV-associated EPTB. In HIV-negative patients, POCUS detected features associated with EPTB but also of malignancy and other infectious diseases.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0486","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T07:00:43Z","timestamp":1508223643000},"page":"266-273","source":"Crossref","is-referenced-by-count":32,"title":["Point-of-Care Ultrasound for Extrapulmonary Tuberculosis in India: A Prospective Cohort Study in HIV-Positive and HIV-Negative Presumptive Tuberculosis Patients"],"prefix":"10.4269","volume":"98","author":[{"given":"Stefan F.","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University Clinics, Mainz, Germany;"},{"name":"Department of Pediatrics, RWTH Aachen University, Aachen, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha","family":"Saravu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kasturba Medical College, Manipal University, Manipal, India;"},{"name":"Manipal McGill Center for Infectious Diseases, Manipal, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Heller","sequence":"additional","affiliation":[{"name":"Lighthouse Clinics, Lilongwe, Malawi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajagopal","family":"Kadavigere","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Kasturba Medical College, Manipal University, Manipal, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashidhar","family":"Vishwanath","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Gehring","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Clinics, Mainz, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"B\u00e9lard","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology, Charit\u00e9 University Medicine, Berlin, Germany;"},{"name":"Berlin Institute of Health, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Clinics, Mainz, Germany;"},{"name":"Department of Pediatrics, RWTH Aachen University, Aachen, Germany;"},{"name":"Department of Medicine, Kasturba Medical College, Manipal University, Manipal, India;"},{"name":"Manipal McGill Center for Infectious Diseases, Manipal, India;"},{"name":"Lighthouse Clinics, Lilongwe, Malawi;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","author":"WHO","year":"2016"},{"key":"b2","series-title":"J Clin Diagn 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