{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:17:18Z","timestamp":1772151438904,"version":"3.50.1"},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,6]]},"abstract":"<jats:p>This study compared the frequency of abnormal electrocardiogram (ECG) types between scrub typhus patient group and age- and gender-matched health checkup group and their associations with disease severity in scrub typhus patient. Demographic characteristics and ECG and laboratory findings of patients with scrub typhus admitted to Chosun University Hospital, and normal subjects visiting the hospital for health checkup from January 2008 to December 2012 were retrospectively studied. Electrocardiogram abnormalities at admission were observed in 72 of 165 (43.6%) scrub typhus confirmed patients. The following ECG abnormalities were observed: arrhythmic group (31 cases, 18.8%), ischemic change group (25 cases, 15.1%), prolonged QT group (32 cases, 19.4%).Compared with the age and gender-matched health checkup group, ECG abnormalities were more commonly observed in scrub typhus patient group (13.9% versus 43.6%, <jats:italic>P<\/jats:italic> &lt; 0.001). In addition, when compared with the normal ECG group, scrub typhus in the abnormal ECG group showed greater disease severity and this phenomenon was particularly prominent in the prolonged QT group. Based on our study prolonged QT observed in approximately 20% of patients with scrub typhus, clinicians should pay additional attention to drugs that affect QT interval.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0565","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T07:02:16Z","timestamp":1549522936000},"page":"399-404","source":"Crossref","is-referenced-by-count":12,"title":["Scrub Typhus and Abnormal Electrocardiography"],"prefix":"10.4269","volume":"100","author":[{"given":"Seo-Won","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Ra","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Jae","family":"Ki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Chosun University, Gwangju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choon-Mee","family":"Kim","sequence":"additional","affiliation":[{"name":"The Division of Natural Medical Sciences, College of Health Science, Chosun University, Gwangju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Hyg Epidemiol Microbiol Immunol","first-page":"18","article-title":"Antigenic diversity of rickettsia tsutsugamushi: epidemiologic and ecologic significance","volume":"12","author":"Elisberg","year":"1968"},{"key":"b2","series-title":"Clin Infect Dis","first-page":"1493","article-title":"Rickettsioses and the international traveler","volume":"39","author":"Jensenius","year":"2004"},{"key":"b3","series-title":"Scand J Infect Dis","first-page":"200","article-title":"Scrub typhus imported to Scandinavia","volume":"38","author":"Jensenius","year":"2006"},{"key":"b4","series-title":"Clin Infect Dis","first-page":"191","article-title":"Multiple organ failure complicating probable scrub typhus","volume":"31","author":"Cracco","year":"2000"},{"key":"b5","series-title":"J Microbiol Immunol Infect","first-page":"240","article-title":"Serious complications in scrub typhus","volume":"31","author":"Tsay","year":"1998"},{"key":"b6","series-title":"Circulation","first-page":"1160","article-title":"The electrocardiogram in population studies. A classification system","volume":"21","author":"Blackburn","year":"1960"},{"key":"b7","series-title":"PLoS Negl Trop Dis","first-page":"e3064","article-title":"Dissemination of Orientia tsutsugamushi and inflammatory responses in a murine model of scrub typhus","volume":"8","author":"Keller","year":"2014"},{"key":"b8","series-title":"Am J Trop Med Hyg","first-page":"769","article-title":"Scrub typhus in northeastern Thailand: eschar distribution, abnormal electrocardiographic findings, and predictors of fatal outcome","volume":"95","author":"Thipmontree","year":"2016"},{"key":"b9","series-title":"Arch Intern Med (Chic)","first-page":"217","article-title":"Absence of electrocardiographic changes in Tsutsugamushi fever (scrub typhus); report of two hundred consecutive cases","volume":"76","author":"Howell","year":"1945"},{"key":"b10","series-title":"Southeast Asian J Trop Med Public Health","first-page":"312","article-title":"Acute scrub typhus in Northern Thailand: EKG changes","volume":"33","author":"Watt","year":"2002"},{"key":"b11","series-title":"Korean J Med","first-page":"301","article-title":"A review of the electrocardiography changes and clinical manifestations of scrub typhus in a single center","volume":"86","author":"Kim","year":"2014"},{"key":"b12","series-title":"J Korean Internal Med","first-page":"298","article-title":"A review of electrocardiography changes and clinical manifestation in scrub typhus in a single center","volume":"86","author":"Hong","year":"2014"},{"key":"b13","series-title":"Korean Circ J","first-page":"515","article-title":"Incidence and risk factors for atrial fibrillation in Korea: the national health insurance service database (2002\u20132010)","volume":"46","author":"Son","year":"2016"},{"key":"b14","series-title":"Ann Trop Paediatr","first-page":"149","article-title":"Acute fulminant myocarditis in scrub typhus","volume":"28","author":"Sittiwangkul","year":"2008"},{"key":"b15","series-title":"Int J Cardiol","first-page":"e18","article-title":"Acute myocardial infarction following scrub typhus infection","volume":"114","author":"Kim","year":"2007"},{"key":"b16","series-title":"Am Heart J","first-page":"314","article-title":"Pathologic study of thirty-one cases of scrub typhus fever with especial reference to the cardiovascular system","volume":"31","author":"Levine","year":"1946"},{"key":"b17","series-title":"Ann Intern Med","first-page":"201","article-title":"Scrub typhus in Dutch New Guinea","volume":"26","author":"Irons","year":"1947"},{"key":"b18","series-title":"Ann Intern Med","first-page":"1130","article-title":"Viral and rickettsial causes of cardiac disease, including the coxsackie virus etiology of pericarditis and myocarditis","volume":"53","author":"Woodward","year":"1960"},{"key":"b19","series-title":"Lancet","first-page":"964","article-title":"Ventricular arrhythmias and hypokalemia","volume":"2","author":"McGowan","year":"1976"},{"key":"b20","series-title":"Jpn Heart J","first-page":"735","article-title":"Torsade de pointes induced by hypocalcemia in a postoperative patient with thyrotoxicosis","volume":"33","author":"Mineoi","year":"1992"},{"key":"b21","series-title":"Infect Chemother","first-page":"58","article-title":"Torsades de pointes by azithromycin in scrub typhus and review on cardiac manifestations of scrub typhus","volume":"40","author":"Lim","year":"2008"},{"key":"b22","author":"Prineas","year":"2010"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/2\/article-p399.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/2\/article-p399.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/2\/article-p399.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T13:46:32Z","timestamp":1722433592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/2\/article-p399.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,6]]},"references-count":22,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.17-0565","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,6]]}}}