{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:43:09Z","timestamp":1768621389894,"version":"3.49.0"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,6]]},"abstract":"<jats:p>A prospective cohort study was conducted to evaluate the incidence and treatment outcomes of syphilis and human immunodeficiency virus (HIV) in inmates from Central Brazil. In 2013, 3,363 inmates from 12 prisons in the state of Mato Grosso do Sul were recruited, and 1,614 remained incarcerated after 1 year. The inmates were interviewed, and blood samples were collected for serological testing for <jats:italic>Treponema pallidum<\/jats:italic> and HIV infections. Inmates infected with <jats:italic>T. pallidum<\/jats:italic> or HIV within the first year were assessed for treatment using prison medical record data, based on Venereal Disease Research Laboratory test results, HIV-1 viral load, and CD4 counts. Acquired syphilis was identified in 5.8% (<jats:italic>N<\/jats:italic> = 95) of the inmates and 74% (<jats:italic>N<\/jats:italic> = 70) of them demonstrated poor treatment outcomes after 1 year. Multivariate analysis revealed that not reporting a stable partner was a risk factor for failure of syphilis treatment. Twenty-five patients had HIV (1.5%) and among those, 13 (52%) had an HIV-1 viral load &gt; 200 copies\/mL after 1 year. The incidence of <jats:italic>T. pallidum<\/jats:italic> and HIV infections was 0.5% (<jats:italic>N<\/jats:italic> = 9). The poor treatment outcomes of syphilis and HIV within Brazilian prisons demonstrate the inadequacy of public health programs. Although the incidence of these infections within the prison population is low, new cases still occur. Our results reinforce the significance of screening programs during prison admission for early detection and treatment of sexually transmitted infections.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0592","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T07:00:37Z","timestamp":1525762837000},"page":"1603-1608","source":"Crossref","is-referenced-by-count":7,"title":["Treatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study"],"prefix":"10.4269","volume":"98","author":[{"given":"Graciela Mendon\u00e7a dos Santos","family":"Bet","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados, Dourados, Mato Grosso do Sul, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gleyce Hellen de Almeida de","family":"Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados, Dourados, Mato Grosso do Sul, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio","family":"Croda","sequence":"additional","affiliation":[{"name":"Instituto Penal de Campo Grande, Ag\u00eancia Estadual de Administra\u00e7\u00e3o do Sistema Penitenci\u00e1rio (Agepen), Mato Grosso do Sul, Campo Grande, Brazil;"},{"name":"Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00edsa Estopa","family":"Correa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados, Dourados, Mato Grosso do Sul, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rom\u00e1rio Oliveira de","family":"Sales","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados, Dourados, Mato Grosso do Sul, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruthe Aline da Silva","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados, Dourados, Mato Grosso do Sul, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Viebrantz Enne Sgarbi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados, Dourados, Mato Grosso do Sul, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Terumi Shiguematsu","family":"Yassuda","sequence":"additional","affiliation":[{"name":"Instituto Penal de Campo Grande, Ag\u00eancia Estadual de Administra\u00e7\u00e3o do Sistema Penitenci\u00e1rio (Agepen), Mato Grosso do Sul, Campo Grande, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Rita","family":"Coimbra Motta-Castro","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ), Campo Grande, Mato Grosso do Sul, Brazil;"},{"name":"Laborat\u00f3rio de Imunologia Cl\u00ednica, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Ant\u00f4nio","family":"Pomp\u00edlio","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina (FAMED), Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Simionatto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados, Dourados, Mato Grosso do Sul, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"An Bras Dermatol","first-page":"111","article-title":"Syphilis: diagnosis, treatment and control","volume":"81","author":"Avelleira","year":"2006"},{"key":"b2","series-title":"BMC Infect Dis","first-page":"479","article-title":"A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy","volume":"15","author":"Se\u00f1a","year":"2015"},{"key":"b3","series-title":"Bull World Health Organ","first-page":"217","article-title":"Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis","volume":"91","author":"Gomez","year":"2013"},{"key":"b4","author":"Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade, 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