{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:51:06Z","timestamp":1778626266970,"version":"3.51.4"},"reference-count":43,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,7]]},"abstract":"<jats:p>To evaluate the dynamics of regulatory T cells (Tregs) during tegumentary leishmaniasis, we assessed peripheral blood and biopsies from 54 patients. Patients with cutaneous leishmaniasis (CL) had a decreased proportion of Tregs in the peripheral blood, but the proportion was higher in the biopsies of lesions. During treatment of CL, circulating Tregs increased reaching normal proportions, whereas antigen-specific interferon-\u03b3 responses diminished. By contrast, circulating Tregs from mucosal leishmaniasis patients failed to normalize during treatment. C-C chemokine receptor type 5 was expressed on a large proportion of Tregs at the site of infection. These results demonstrate increased Tregs at the site of infection, possibly homing from the peripheral circulation.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0624","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T07:00:36Z","timestamp":1517900436000},"page":"753-758","source":"Crossref","is-referenced-by-count":10,"title":["Regulatory T-Cell Dynamics in Cutaneous and Mucocutaneous Leishmaniasis due to Leishmania braziliensis"],"prefix":"10.4269","volume":"98","author":[{"given":"Nicolas","family":"Barros","sequence":"first","affiliation":[{"name":"Instituto de Medicina Tropical \u201cAlexander von Humboldt\u201d, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nestor","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical \u201cAlexander von Humboldt\u201d, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Woll","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical \u201cAlexander von Humboldt\u201d, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical \u201cAlexander von Humboldt\u201d, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Braulio","family":"Valencia","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical \u201cAlexander von Humboldt\u201d, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Llanos-Cuentas","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical \u201cAlexander von Humboldt\u201d, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Clinton","family":"White Jr.","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical \u201cAlexander von Humboldt\u201d, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Montes","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical \u201cAlexander von Humboldt\u201d, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"1561","article-title":"Advances in leishmaniasis","volume":"366","author":"Murray","year":"2005"},{"key":"b2","series-title":"Clin Infect 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