{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:07:43Z","timestamp":1790554063838,"version":"4.1.0"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,7]]},"abstract":"<jats:p>Dihydroartemisinin\u2013piperaquine (DHP) has been the first-line treatment of uncomplicated malaria due to both <jats:italic>Plasmodium falciparum<\/jats:italic> and <jats:italic>Plasmodium vivax<\/jats:italic> infections in Papua, Indonesia, since March 2006. The efficacy of DHP was reassessed to determine whether there had been any decline following almost a decade of its extensive use. An open-label drug efficacy study of DHP for uncomplicated <jats:italic>P. falciparum<\/jats:italic> and <jats:italic>P. vivax<\/jats:italic> malaria was carried out between March 2015 and April 2016 in Timika, Papua, Indonesia. Patients with uncomplicated malaria were administered supervised DHP tablets once daily for 3 days. Clinical and laboratory data were collected daily until parasite clearance and then weekly for 6 weeks. Molecular analysis was undertaken for all patients with recurrent parasitemia. A total of 129 study patients were enrolled in the study. At day 42, the polymerase chain reaction-adjusted efficacy was 97.7% (95% confidence intervals [CI]: 87.4\u201399.9) in the 61 patients with <jats:italic>P. falciparum<\/jats:italic> malaria, and 98.2% [95% CI: 90.3\u2013100] in the 56 patients with <jats:italic>P. vivax<\/jats:italic> malaria. By day 2, 98% (56\/57) of patients with <jats:italic>P. falciparum<\/jats:italic> and 96.9% (63\/65) of those with <jats:italic>P. vivax<\/jats:italic> had cleared their peripheral parasitemia; none of the patients were still parasitaemic on day 3. Molecular analysis of <jats:italic>P. falciparum<\/jats:italic> parasites showed that none (0\/61) had K13 mutations associated previously with artemisinin resistance or increased copy number of <jats:italic>plasmepsin<\/jats:italic> 2\u20133 (0\/61). In the absence of artemisinin resistance, DHP has retained high efficacy for the treatment of uncomplicated malaria despite extensive drug pressure over a 9-year period.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0662","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T07:00:19Z","timestamp":1516086019000},"page":"677-682","source":"Crossref","is-referenced-by-count":28,"title":["Therapeutic Response to Dihydroartemisinin\u2013Piperaquine for P. falciparum and P. vivax Nine Years after Its Introduction in Southern Papua, Indonesia"],"prefix":"10.4269","volume":"98","author":[{"given":"Jeanne Rini","family":"Poespoprodjo","sequence":"first","affiliation":[{"name":"Mimika District Hospital, Timika, Indonesia;"},{"name":"Timika Malaria Research Programme, Papuan Health and Community Development Foundation, Timika, Indonesia;"},{"name":"Paediatric Research Office, Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada\/Dr. Sardjito Hospital, Yogyakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enny","family":"Kenangalem","sequence":"additional","affiliation":[{"name":"Mimika District Hospital, Timika, Indonesia;"},{"name":"Timika Malaria Research Programme, Papuan Health and Community Development Foundation, Timika, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johny","family":"Wafom","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Programme, Papuan Health and Community Development Foundation, Timika, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freis","family":"Chandrawati","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Programme, Papuan Health and Community Development Foundation, Timika, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agatha M.","family":"Puspitasari","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Ley","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leily","family":"Trianty","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00e9","family":"Korten","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asik","family":"Surya","sequence":"additional","affiliation":[{"name":"Indonesian Ministry of Health, National Malaria Control Program, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Din","family":"Syafruddin","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Anstey","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Marfurt","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintis","family":"Noviyanti","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ric N.","family":"Price","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Malar J","first-page":"148","article-title":"Malaria morbidity in Papua, Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum","volume":"7","author":"Karyana","year":"2008"},{"key":"b2","series-title":"Adv Parasitol","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/B978-0-12-385897-9.00002-1","article-title":"Malaria distribution, prevalence, drug resistance and control in 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