{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:10:49Z","timestamp":1792271449354,"version":"4.4.0"},"reference-count":44,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,7]]},"abstract":"<jats:p>The treatment of mansonelliasis is still a challenge because there are few clinical trials for the treatment of the disease. This double-blind, randomized, placebo-controlled study (phase III clinical trial) was conducted to evaluate the effectiveness of a single oral dose of ivermectin (0.15 mg\/kg) in the reduction of the <jats:italic>Mansonella ozzardi<\/jats:italic> microfilaraemia and the occurrence of adverse effects in infected people compared with the control group treated with placebo. A total of 49 microfilaraemic patients were randomly selected from the municipality of L\u00e1brea, State of Amazonas, in the Brazilian Amazon. Among them, 40 patients have concluded the study, 19 treated with ivermectin and 21 treated with placebo. In the first and third days after the treatment, all the patients were clinically evaluated, and the diagnostic and quantification of blood microfilariae through blood filtration in polycarbonate membranes was performed. A significant reduction of the microfilaraemia (99.9%) was observed in the patients who received ivermectin. Slight changes in laboratory test results, without clinical importance, were seen in treated and control groups. Our results suggest that ivermectin is effective and safe for the treatment of infections caused by <jats:italic>M. ozzardi<\/jats:italic>.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0698","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T07:00:32Z","timestamp":1515481232000},"page":"786-790","source":"Crossref","is-referenced-by-count":16,"title":["Phase III Clinical Trial to Evaluate Ivermectin in the Reduction of Mansonella ozzardi infection in the Brazilian Amazon"],"prefix":"10.4269","volume":"98","author":[{"given":"Sergio","family":"de Almeida Basano","sequence":"first","affiliation":[{"name":"Secretaria de Sa\u00fade do Estado de Rond\u00f4nia, Porto Velho, Brazil;"},{"name":"Departamento de Medicina, Centro Universit\u00e1rio S\u00e3o Lucas, Porto Velho, Brazil;"},{"name":"Universidade Federal de S\u00e3o Jo\u00e3o Del Rei, Campus Centro Oeste, Divin\u00f3polis, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"de Souza Almeida Aranha Camargo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Centro Universit\u00e1rio S\u00e3o Lucas, Porto Velho, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Fontes","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o Del Rei, Campus Centro Oeste, Divin\u00f3polis, Brazil;"},{"name":"Instituto Nacional de Epidemiologia na Amazo\u0302nia Ocidental, Porto Velho, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonieta Relvas","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o Del Rei, Campus Centro Oeste, Divin\u00f3polis, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jansen Fernandes","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Epidemiologia na Amazo\u0302nia Ocidental, Porto Velho, Brazil;"},{"name":"Fiocruz-Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Porto Velho, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Costa","family":"de Oliveira Laudisse","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Centro Universit\u00e1rio S\u00e3o Lucas, Porto Velho, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"de Godoi Mattos Ferreira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Epidemiologia na Amazo\u0302nia Ocidental, Porto Velho, Brazil;"},{"name":"Fiocruz-Rond\u00f4nia, Funda\u00e7\u00e3o Oswaldo Cruz, Porto Velho, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Marcelo Aranha","family":"Camargo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Centro Universit\u00e1rio S\u00e3o Lucas, Porto Velho, Brazil;"},{"name":"Instituto Nacional de Epidemiologia na Amazo\u0302nia Ocidental, Porto Velho, Brazil;"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas 5 (ICB5 USP), Universidade de S\u00e3o Paulo, Monte Negro, Brazil;"},{"name":"Centro de Pesquisas em Medicina Tropical de Rond\u00f4nia\/SESAU, Porto Velho, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Rev Bras Malariol Doencas Trop","first-page":"437","article-title":"Filarioses humanas nas sedes municipais do Estado do Amazonas e territ\u00f3rios do Acre, Guapor\u00e9 Rio Branco","volume":"8","author":"Lacerda","year":"1956"},{"key":"b2","series-title":"Mem Inst Oswaldo Cruz","first-page":"451","article-title":"Simuliid blackflies (Diptera: Simuliidae) and ceratopogonid midges (Diptera: 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