{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:30:19Z","timestamp":1793331019664,"version":"4.5.0"},"reference-count":38,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,3]]},"abstract":"<jats:p>We used whole-genome sequencing to investigate a tuberculosis outbreak involving U.S.-born persons in the prison system and both U.S.- and foreign-born persons in the community in Florida over a 7-year period (2009\u20132015). Genotyping by spacer oligonucleotide typing and 24-locus mycobacterial interspersed repetitive unit-variable number tandem repeat suggested that the outbreak might be clonal in origin. However, contact tracing could not link the two populations. Through a multidisciplinary approach, we showed that the cluster involved distinct bacterial transmission networks segregated by country of birth. The source strain is of foreign origin and circulated in the local Florida community for more than 20 years before introduction into the prison system. We also identified novel transmission links involving foreign and U.S.-born cases not discovered during contact investigation. Our data highlight the potential for spread of strains originating from outside the United States into U.S. \u201chigh-risk\u201d populations, such as prisoners, with subsequent movement back to the general community.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0700","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T07:01:04Z","timestamp":1531206064000},"page":"867-874","source":"Crossref","is-referenced-by-count":22,"title":["Genomic Investigation of a Mycobacterium tuberculosis Outbreak Involving Prison and Community Cases in Florida, United States"],"prefix":"10.4269","volume":"99","author":[{"given":"Marie Nancy","family":"S\u00e9raphin","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida;"},{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Didelot","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, Florida;"},{"name":"Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida;"},{"name":"Bioinfoexperts, LLC, Thibodaux, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"May","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida;"},{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Siddiqur Rahman","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida;"},{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen R.","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida;"},{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Salemi","sequence":"additional","affiliation":[{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, Florida;"},{"name":"Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Glenn","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida;"},{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lauzardo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida;"},{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Emerg Infect Dis","first-page":"1188","article-title":"Rationale and methods for the national tuberculosis genotyping and surveillance network","volume":"8","author":"Castro","year":"2002"},{"key":"b2","series-title":"Emerg Infect 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