{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:14:01Z","timestamp":1722471241231},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,5]]},"abstract":"<jats:p>Devices to safely transfer fixed amounts of finger prick blood to rapid diagnostic tests (RDTs) pose a significant challenge, especially in non-laboratory settings. Following the success of an \u201cinverted cup device\u201d for transfer of 5 \u03bcL blood, a prototype with a conical cup shape was developed for transfer of 20 \u03bcL blood, the amount needed for human immunodeficiency virus or human African trypanosomiasis (HAT) RDTs. This study determined the volume of blood transferred by this new blood transfer device (BTD) and compared its ease of use, safety, and acceptability with that of a plastic pipette when used by health workers (HWs) for HAT RDTs in northwestern Uganda. After a half-day training, 48 HWs had used the two BTDs with at least 10 patients. The conical cup BTD effectively transferred a mean of 22.76 \u03bcL of blood (standard deviation 3.31 \u03bcL). A significantly higher proportion of HWs were able to collect the full amount of blood using the conical cup BTD, as compared with the pipette (92.4% versus 74.2%, <jats:italic>P<\/jats:italic> &lt; 0.001). In HW questionnaires, the conical cup BTD scored higher than the pipette in various aspects of ease of use and safety. In addition, HWs preferred the conical cup BTD (79%), indicating that it was easy to handle, made work faster, and increased their confidence in front of the patient. These findings suggest that the design of the conical cup BTD may be adapted for RDTs requiring 20 \u03bcL of blood to facilitate safe and accurate blood transfer.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0716","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T07:00:20Z","timestamp":1531810820000},"page":"797-804","source":"Crossref","is-referenced-by-count":3,"title":["Accuracy, Ease of Use, Safety, and Acceptability of a 23-\u03bcL Conical Cup Blood Transfer Device for Use with Rapid Diagnostic Tests"],"prefix":"10.4269","volume":"99","author":[{"given":"Sandra","family":"Incardona","sequence":"first","affiliation":[{"name":"Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Kyabayinze","sequence":"additional","affiliation":[{"name":"National Malaria Control Division, Ministry of Health, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bell","sequence":"additional","affiliation":[{"name":"Intellectual Ventures, Global Good Fund, Bellevue, Washington;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bbale","family":"Ndawula","sequence":"additional","affiliation":[{"name":"School of Biomedical Science, Makerere University, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvis C.","family":"Kanyago","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital International, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magoma C.","family":"Mwancha-Kwasa","sequence":"additional","affiliation":[{"name":"Health Research and Development Unit, Ministry of Health, Kiambu, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iveth J.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"BMC Public Health","first-page":"470","article-title":"Use of malaria RDTs in various health contexts across sub-Saharan Africa: a systematic review","volume":"17","author":"Boyce","year":"2017"},{"key":"b2","series-title":"PLoS One","first-page":"e0180555","article-title":"Performance of the SD BIOLINE\u00ae HAT rapid test in various diagnostic algorithms for gambiense human African trypanosomiasis in the Democratic Republic of the Congo","volume":"12","author":"Lumbala","year":"2017"},{"key":"b3","series-title":"Clin Microbiol Infect","first-page":"399","article-title":"Malaria rapid diagnostic tests in endemic settings","volume":"19","author":"Maltha","year":"2013"},{"key":"b4","series-title":"PLoS Negl Trop Dis","first-page":"e3373","article-title":"Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis","volume":"8","author":"Sternberg","year":"2014"},{"key":"b5","series-title":"Am J Trop Med Hyg","first-page":"57","article-title":"Community health workers use malaria rapid diagnostic tests (RDTs) safely and accurately: results of a longitudinal study in Zambia","volume":"87","author":"Counihan","year":"2012"},{"key":"b6","series-title":"Trop Med Int Health","first-page":"325","article-title":"Short communication: an assessment of the use of malaria rapid tests by village health volunteers in rural Laos","volume":"9","author":"Mayxay","year":"2004"},{"key":"b7","series-title":"Malar J","first-page":"229","article-title":"Success or failure of critical steps in community case management of malaria with rapid diagnostic tests: a systematic review","volume":"13","author":"Ruizendaal","year":"2014"},{"key":"b8","series-title":"Malar J","first-page":"160","article-title":"Improving community health worker use of malaria rapid diagnostic tests in Zambia: package instructions, job aid and job aid-plus-training","volume":"7","author":"Harvey","year":"2008"},{"key":"b9","series-title":"PLoS One","first-page":"e29550","article-title":"Surveillance for malaria elimination in Swaziland: a national cross-sectional study using pooled PCR and serology","volume":"7","author":"Hsiang","year":"2012"},{"key":"b10","series-title":"PLoS One","first-page":"e4351","article-title":"The evaluation of a rapid in situ HIV confirmation test in a programme with a high failure rate of the WHO HIV two-test diagnostic algorithm","volume":"4","author":"Klarkowski","year":"2009"},{"key":"b11","series-title":"J Med Microbiol","first-page":"1491","article-title":"Malaria rapid diagnostic tests: challenges and prospects","volume":"62","author":"Mouatcho","year":"2013"},{"key":"b12","series-title":"Trans R Soc Trop Med Hyg","first-page":"9","article-title":"Minimising human error in malaria rapid diagnosis: clarity of written instructions and health worker performance","volume":"101","author":"Rennie","year":"2007"},{"key":"b13","series-title":"Trans R Soc Trop Med Hyg","first-page":"25","article-title":"Assessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria","volume":"102","author":"Fogg","year":"2008"},{"key":"b14","series-title":"Malar J","first-page":"128","article-title":"Performance of self-diagnosis and standby treatment of malaria in international oilfield service employees in the field","volume":"7","author":"Roukens","year":"2008"},{"key":"b15","series-title":"Trop Med Int Health","first-page":"406","article-title":"End-user errors in applying two malaria rapid diagnostic tests in a remote area of Sudan","volume":"13","author":"Seidahmed","year":"2008"},{"key":"b16","series-title":"Malar J","first-page":"149","article-title":"An assessment of various blood collection and transfer methods used for malaria rapid diagnostic tests","volume":"6","author":"Luchavez","year":"2007"},{"key":"b17","series-title":"Malar J","first-page":"30","article-title":"Blood transfer devices for malaria rapid diagnostic tests: evaluation of accuracy, safety and ease of use","volume":"10","author":"Hopkins","year":"2011"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/3\/article-p797.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/3\/article-p797.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/3\/article-p797.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T19:56:11Z","timestamp":1722455771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/3\/article-p797.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":17,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.17-0716","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2018,9,5]]}}}