{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T21:29:59Z","timestamp":1773437399874,"version":"3.50.1"},"reference-count":26,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,7]]},"abstract":"<jats:p>Severe congenital malaria associated with <jats:italic>Plasmodium vivax<\/jats:italic> is uncommon. In Indonesia, most congenital malaria cases are due to <jats:italic>Plasmodium falciparum<\/jats:italic> infections. Most cases of congenital or neonatal malaria in endemic areas are diagnosed from peripheral smear as part of routine sepsis workup. Differentiating congenital and acquired neonatal malaria is very difficult. The case presented in this study describes severe <jats:italic>P. vivax<\/jats:italic> malaria with cholestatic jaundice and sepsis-like signs and symptoms in neonates. The mother was asymptomatic and the neonate was successfully treated with intravenous artesunate. Severe <jats:italic>P. vivax<\/jats:italic> malaria with cholestatic jaundice in neonates is an uncommon condition that should be included in the differential diagnosis of infants displaying hemolytic anemia, thrombocytopenia, cholestatic jaundice, and hepatosplenomegaly in malaria-endemic zones. Early diagnosis can prevent the use of unnecessary antibiotics and mortality of neonates.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0739","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T07:00:25Z","timestamp":1515481225000},"page":"656-659","source":"Crossref","is-referenced-by-count":9,"title":["Case Report: Severe Plasmodium vivax Malaria Mimicking Sepsis in a Neonate"],"prefix":"10.4269","volume":"98","author":[{"given":"Suryadi N. N.","family":"Tatura","sequence":"first","affiliation":[{"name":"Pediatric Infectious and Tropical Disease Division, Department of Pediatrics, Faculty of Medicine, Prof. Dr. R. D. Kandou General Hospital, Manado, Indonesia;"},{"name":"Infectious and Tropical Disease Division, Faculty of Medicine, Department of Pediatrics, Sam Ratulangi University, Manado, Indonesia;"},{"name":"Indonesian National Expert Committee of Malaria, Ministry of Health, Jakarta, Republic of Indonesia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Clarissa","family":"Wowor","sequence":"additional","affiliation":[{"name":"Pediatric Infectious and Tropical Disease Division, Department of Pediatrics, Faculty of Medicine, Prof. Dr. R. D. Kandou General Hospital, Manado, Indonesia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Mandei","sequence":"additional","affiliation":[{"name":"Emergency and Intensive Care Division, Department of Pediatrics, Prof. Dr. R. D. Kandou General Hospital, Manado, Indonesia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocky","family":"Wilar","sequence":"additional","affiliation":[{"name":"Neonatology Division, Department of Pediatrics, Prof. Dr. R. D. Kandou General Hospital, Manado, Indonesia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"Warouw","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Division, Department of Pediatrics, Prof. Dr. R. D. Kandou General Hospital, Manado, Indonesia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Rompis","sequence":"additional","affiliation":[{"name":"Neonatology Division, Department of Pediatrics, Prof. Dr. R. D. Kandou General Hospital, Manado, Indonesia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Kalensang","sequence":"additional","affiliation":[{"name":"Pediatric Infectious and Tropical Disease Division, Department of Pediatrics, Faculty of Medicine, Prof. Dr. R. D. Kandou General Hospital, Manado, Indonesia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Tuda","sequence":"additional","affiliation":[{"name":"Department of Clinical Parasitology, Faculty of Medicine, Prof. Dr. R. D. Kandou General Hospital, Manado, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"ASH KMDC","first-page":"71","article-title":"Congenital malaria in a neonate: a rare condition","volume":"22","author":"Raza","year":"2017"},{"key":"b2","series-title":"Trop Med Int Health","first-page":"7","article-title":"Severe malaria","volume":"19","author":"World Health Organization","year":"2014"},{"key":"b3","series-title":"Malar J","first-page":"1","article-title":"Congenital malaria in Uraba, Colombia","volume":"10","author":"Pineros-Jimenez","year":"2011"},{"key":"b4","first-page":"1","author":"Bhatia","year":"2016"},{"key":"b5","series-title":"Sch J Med Case Rep","first-page":"315","article-title":"P. vivax malaria: a rare cause of cholestatic jaundice in a neonate","volume":"4","author":"Bagri","year":"2016"},{"key":"b6","series-title":"Med J Armed Forces India","first-page":"185","article-title":"Congenital malaria","volume":"64","author":"Thapar","year":"2008"},{"key":"b7","series-title":"Pediatric Infect Dis","first-page":"33","article-title":"Congenital Plasmodium vivax malaria in a non-endemic country; 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