{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:15:37Z","timestamp":1774955737966,"version":"3.50.1"},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,9]]},"abstract":"<jats:p>Empirical knowledge suggests that acute neurologic disorders are common in sub-Saharan Africa, but studies examining the true burden of these diseases in children are scarce. We performed this prospective, observational study to evaluate the prevalence, clinical characteristics, treatment approaches, and outcomes of children suffering acute neurologic illness or injury (ANI) in an urban and rural site in the Democratic Republic of the Congo. Over 12 months, 471 out of 6,563 children admitted met diagnostic criteria for ANI, giving a hospital-based prevalence of 72\/1,000 admissions. Two hundred and seventy-two children had clinical findings consistent with central nervous system infection but lacked complete diagnostic evaluation for definitive classification. Another 151 children were confirmed to have cerebral malaria (<jats:italic>N<\/jats:italic> = 109, 23% of admissions), bacterial meningitis (<jats:italic>N<\/jats:italic> = 38, 8% of admissions), tuberculous meningitis (<jats:italic>N<\/jats:italic> = 3, 0.6% of admissions), or herpes encephalitis (<jats:italic>N<\/jats:italic> = 1, 0.21% of admissions). Febrile convulsions, traumatic brain injury, and epilepsy contributed less significantly to overall hospital prevalence of ANI (3.19\/1,000, 1.37\/1,000, and 1.06\/1,000, respectively). Overall mortality for the cohort was 21% (97\/471). Neurologic sequelae were seen in another 31% of participants, with only 45% completing the study with a normal neurologic examination. This type of data is imperative to help plan effective strategies for illness and injury prevention and control, and to allow optimal use of limited resources in terms of provision of acute care and rehabilitation for these children.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0784","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T07:00:21Z","timestamp":1520319621000},"page":"1534-1540","source":"Crossref","is-referenced-by-count":10,"title":["Pediatric Acute Severe Neurologic Illness and Injury in an Urban and a Rural Hospital in the Democratic Republic of the Congo"],"prefix":"10.4269","volume":"98","author":[{"given":"Taty","family":"Tshimangani","sequence":"first","affiliation":[{"name":"Hopital Pediatrique de Kalembe Lembe, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Pongo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universite des Sciences et des Technologie de Lodja, Lodja, Democratic Republic of the Congo;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Bodi Mabiala","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Yotebieng","sequence":"additional","affiliation":[{"name":"Ohio State University, College of Public Health, Columbus, Ohio;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole F.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nationwide Children\u2019s Hospital, Columbus, Ohio;"},{"name":"The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"AJNS","first-page":"19","article-title":"Neurological disorders in rural Africa: a systematic approach","volume":"27","author":"Winkler","year":"2008"},{"key":"b2","series-title":"West Afr J Med","first-page":"80","article-title":"Paediatric neurologic emergencies at the University of Nigeria Teaching Hospital, Enugu","volume":"16","author":"Iloeje","year":"1997"},{"key":"b3","series-title":"J Natl Med Assoc","first-page":"488","article-title":"Pattern of emergency neurologic morbidities in children","volume":"97","author":"Ofovwe","year":"2005"},{"key":"b4","series-title":"Trans R Soc Trop Med Hyg","first-page":"S1","article-title":"Severe falciparum malaria. World Health Organization, communicable diseases cluster","volume":"94","author":"Wolrd Health Organization","year":"2000"},{"key":"b5","series-title":"Trans R Soc Trop Med Hyg","first-page":"619","article-title":"A review of the spectrum of clinical ocular fundus findings in P. falciparum malaria in African children with a proposed classification and grading system","volume":"93","author":"Lewallen","year":"1999"},{"key":"b6","series-title":"Arch Ophthalmol","first-page":"924","article-title":"Clinical-histopathological correlation of the abnormal retinal vessels in cerebral malaria","volume":"118","author":"Lewallen","year":"2000"},{"key":"b7","series-title":"Am J Trop Med Hyg","first-page":"790","article-title":"Malarial retinopathy: a newly established diagnostic sign in severe malaria","volume":"75","author":"Beare","year":"2006"},{"key":"b8","series-title":"Trop Doct","first-page":"1","article-title":"Classifying and grading retinal signs in severe malaria","volume":"36","author":"Harding","year":"2006"},{"key":"b9","series-title":"Braz J Infect Dis","first-page":"401","article-title":"Prediction of bacterial meningitis based on cerebrospinal fluid pleocytosis in children","volume":"17","author":"Agueda","year":"2013"},{"key":"b10","series-title":"J Perinatol","first-page":"62","article-title":"Is home-based diagnosis and treatment of neonatal sepsis feasible and effective? Seven years of intervention in the Gadchiroli field trial (1996 to 2003)","volume":"25","author":"Bang","year":"2005"},{"key":"b11","series-title":"Health Aff (Millwood)","first-page":"1196","article-title":"Simulations show diagnostic testing for malaria in young African children can be cost-saving or cost-effective","volume":"34","author":"Phillips","year":"2015"},{"key":"b12","series-title":"Trop Doct","first-page":"82","article-title":"Neurologic disease in a rural Zambian hospital","volume":"31","author":"Birbeck","year":"2001"},{"key":"b13","series-title":"Neurology","first-page":"412","article-title":"Neurologic services in the nations of Africa","volume":"64","author":"Bower","year":"2005"},{"key":"b14","series-title":"Lancet ID","first-page":"546","article-title":"Rapid diagnostic tests for central nervous system infections in central Africa","volume":"13","author":"Yansouni","year":"2013"},{"key":"b15","series-title":"Nature","first-page":"73","article-title":"Requirements for high impact diagnostics in the developing world","volume":"444","author":"Urdea","year":"2006"},{"key":"b16","series-title":"Nature","first-page":"214","article-title":"The global distribution of clinical episodes of Plasmodium falciparum malaria","volume":"434","author":"Snow","year":"2005"},{"key":"b17","series-title":"Parasitol Today","first-page":"105","article-title":"A climate-based distribution model of malaria transmission in sub-Saharan Africa","volume":"15","author":"Craig","year":"1999"},{"key":"b18","series-title":"Interdiscip Perspect Infect Dis","first-page":"1","article-title":"The impact of cooperative social organization on reducing the prevalence of malaria and intestinal parasite infections in Awramba, a rural community in south Gondar, Ethiopia","volume":"6","author":"Yihenew","year":"2014"},{"key":"b19","series-title":"Nature","first-page":"207","article-title":"The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015","volume":"526","author":"Bhatt","year":"2015"},{"key":"b20","author":"Ulimwengu","year":"2009"},{"key":"b21","author":"Novelli","year":"1999"},{"key":"b22","series-title":"Lancet ID","first-page":"317","article-title":"Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis","volume":"10","author":"Edmond","year":"2010"},{"key":"b23","author":"Saez-Llorens","year":"2008"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/98\/5\/article-p1534.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/98\/5\/article-p1534.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/98\/5\/article-p1534.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T17:12:30Z","timestamp":1722445950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/98\/5\/article-p1534.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,9]]},"references-count":23,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.17-0784","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,9]]}}}