{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:33:46Z","timestamp":1788042826338,"version":"build-2784847793"},"reference-count":47,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,5]]},"abstract":"<jats:p>Lymphatic filariasis is a mosquito-borne parasitic infection caused by <jats:italic>Wuchereria bancrofti<\/jats:italic> and <jats:italic>Brugia<\/jats:italic> spp. Commonly seen in tropical developing countries, lymphatic filariasis occurs when adult worms deposit in and obstruct lymphatics. Although not endemic to the United States, a few cases of lymphatic filariasis caused by zoonotic <jats:italic>Brugia<\/jats:italic> spp. have been reported. Here we present a case of an 11-year-old female with no travel history who was seen in our clinic for a 1-year history of painless left cervical lymphadenopathy secondary to lymphatic filariasis. We review the literature of this infection and discuss the management of our patient. Using the National Inpatient Sample (NIS), the largest publicly available all-payer inpatient care database in the United States, we also examine the demographics of this infection. Our results show that chronic lymphadenopathy in the head and neck is the most common presenting symptoms of domestic lymphatic filariasis. Diagnosis is often made after surgical lymph node excision. Examination of the NIS from 2000 to 2014 revealed 865 patients admitted with a diagnosis of lymphatic filariasis. Most patients are in the mid to late sixties and are located on the eastern seaboard. Eight hundred and twenty six cases (95.5%) were likely due to zoonotic <jats:italic>Brugia<\/jats:italic> spp. and 39 (4.5%) due to <jats:italic>W. bancrofti<\/jats:italic>. Despite being rare, these data highlight the need to consider filariasis in patients presenting with chronic lymphadenopathy in the United States.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0786","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T07:00:25Z","timestamp":1527663625000},"page":"104-111","source":"Crossref","is-referenced-by-count":8,"title":["Cervical Lymphatic Filariasis in a Pediatric Patient: Case Report and Database Analysis of Lymphatic Filariasis in the United States"],"prefix":"10.4269","volume":"99","author":[{"given":"Jonathan C.","family":"Simmonds","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Tufts Medical Center, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid I.","family":"Dagher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Tufts Medical Center, Boston, Massachusetts;"},{"name":"ENT Specialists, Inc., Brockton, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Microbiol Rev","first-page":"366","article-title":"Zoonotic filariasis","volume":"11","author":"Orihel","year":"1998"},{"key":"b2","series-title":"Lancet","first-page":"1175","article-title":"Lymphatic filariasis and onchocerciasis","volume":"376","author":"Taylor","year":"2010"},{"key":"b3","series-title":"Parasitol Today","first-page":"472","article-title":"Global mapping of lymphatic filariasis","volume":"13","author":"Michael","year":"1997"},{"key":"b4","series-title":"PLoS Negl Trop Dis","first-page":"e3319","article-title":"Progress and impact of 13 years of the global programme to eliminate lymphatic filariasis on reducing the burden of filarial disease","volume":"8","author":"Ramaiah","year":"2014"},{"key":"b5","author":"World Health Organization","year":"2016"},{"key":"b6","series-title":"Am J Trop Med Hyg","first-page":"1205","article-title":"North American brugian filariasis","volume":"35","author":"Baird","year":"1986"},{"key":"b7","series-title":"Am J Clin Pathol","first-page":"384","article-title":"Zoonotic brugian lymphadenitis. 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