{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:16:02Z","timestamp":1790381762132,"version":"4.1.0"},"reference-count":44,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,2]]},"abstract":"<jats:p>Argentine hemorrhagic fever (AHF) is a serious endemic disease in Argentina, produced by Jun\u00edn virus, whose host is the Sigmodontinae rodent <jats:italic>Calomys musculinus<\/jats:italic>. Within the endemic area, human incidence and proportion of infected rodents remains high for 5\u201310 years after the first appearance of the disease (epidemic [E] zone) and then gradually declines to sporadic cases (historic [H] zone). We tested the hypothesis that host populations within the E zone are large and well connected by gene flow, facilitating the transmission and maintenance of the virus, whereas those in the H and nonendemic (NE) zones are small and isolated, with the opposite effect. We estimated parameters affected by levels of gene flow and population size in 14 populations of <jats:italic>C. musculinus<\/jats:italic>: population effective size (<jats:italic>N<\/jats:italic><jats:sub>e<\/jats:sub>), genetic variability, and mean relatedness. Our hypothesis was not supported: the lowest levels of variability and of <jats:italic>N<\/jats:italic><jats:sub>e<\/jats:sub> and the highest genetic relatedness among individuals were found in the H zone. Populations from the NE zone displayed opposite results, whereas those in the E zone showed intermediate values. If we consider that populations are first NE, then E, and finally H, a correlative decrease in <jats:italic>N<\/jats:italic><jats:sub>e<\/jats:sub> was observed. Chronically infected females have a low reproductive success. We propose that this would lower <jats:italic>N<\/jats:italic><jats:sub>e<\/jats:sub> because each cohort would originate from a fraction of females of the previous generation, and affect other factors such as proportion of individuals that develop acute infection, probability of viral transmission, and evolution of virulence, which would explain, at least partly, the changing incidence of AHF.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0838","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T07:00:27Z","timestamp":1528786827000},"page":"445-450","source":"Crossref","is-referenced-by-count":6,"title":["Effective Population Size Differences in Calomys musculinus, the Host of Jun\u00edn Virus: Their Relationship with the Epidemiological History of Argentine Hemorrhagic Fever"],"prefix":"10.4269","volume":"99","author":[{"given":"Marina B.","family":"Chiappero","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Gen\u00e9tica de Poblaciones y Evoluci\u00f3n, Facultad de Ciencias Exactas, F\u00edsicas y Naturales, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina;"},{"name":"Instituto de Diversidad y Ecolog\u00eda Animal (IDEA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), C\u00f3rdoba, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Florencia","family":"Piacenza","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Naturales, Universidad Nacional de R\u00edo Cuarto, R\u00edo Cuarto, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Cecilia","family":"Provensal","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Naturales, Universidad Nacional de R\u00edo Cuarto, R\u00edo Cuarto, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys E.","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Virales Humanas, \u201cDr. Julio I. Maiztegui\u201d, Pergamino, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina N.","family":"Gardenal","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Gen\u00e9tica de Poblaciones y Evoluci\u00f3n, Facultad de Ciencias Exactas, F\u00edsicas y Naturales, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina;"},{"name":"Instituto de Diversidad y Ecolog\u00eda Animal (IDEA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), C\u00f3rdoba, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime J.","family":"Polop","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Naturales, Universidad Nacional de R\u00edo Cuarto, R\u00edo Cuarto, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Wildl Res","first-page":"112","article-title":"Habitat use by corn mice (Calomys musculinus) in cropfield 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