{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:18:13Z","timestamp":1772500693891,"version":"3.50.1"},"reference-count":33,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,9]]},"abstract":"<jats:p>The potential for transfusion transmission of dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) has raised concerns about the safety of the blood supply in endemic areas. In this study, nucleic acid testing (NAT) for ZIKV, DENV, and CHIKV RNA was performed in asymptomatic blood donor samples in the city of Campinas, located in the southeast region of Brazil (1962 in 2015 and 1775 in 2016). The prevalence of reactive NAT was 0.15% in 2015 and 0.62% in 2016 for dengue, 0.05% in 2015 and 0.17% in 2016 for Zika, and 0% in both years for chikungunya. These results demonstrate the weakness of the clinical interview in screening these blood donors. Furthermore, positivity for ZIKV was detected in March 2015, 1 year before the first reported cases in the region. These data attest the feasibility of using donor samples held in library as a tool for retrospective epidemiological evaluation, which is particularly interesting considering emerging pathogens, for which data on their spread and penetrance are initially scarce.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0843","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T07:00:25Z","timestamp":1541487625000},"page":"174-177","source":"Crossref","is-referenced-by-count":11,"title":["Zika Virus and the Safety of Blood Supply in Brazil: A Retrospective Epidemiological Evaluation"],"prefix":"10.4269","volume":"100","author":[{"given":"Bruno Deltreggia","family":"Benites","sequence":"first","affiliation":[{"name":"Hematology and Transfusion Medicine Center, University of Campinas, Campinas, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Rocha","sequence":"additional","affiliation":[{"name":"Institute of Technology in Immunobiology Bio-Manguinhos, Oswaldo Cruz Foundation\/Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabete","family":"Andrade","sequence":"additional","affiliation":[{"name":"Institute of Technology in Immunobiology Bio-Manguinhos, Oswaldo Cruz Foundation\/Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela T.","family":"Godoy","sequence":"additional","affiliation":[{"name":"Institute of Technology in Immunobiology Bio-Manguinhos, Oswaldo Cruz Foundation\/Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Institute of Technology in Immunobiology Bio-Manguinhos, Oswaldo Cruz Foundation\/Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Addas-Carvalho","sequence":"additional","affiliation":[{"name":"Hematology and Transfusion Medicine Center, University of Campinas, Campinas, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"WHO Reference Number: WHO\/ZIKV\/PHR\/16.1","author":"World Health Organization Zika Virus Research Agenda","year":"2016"},{"key":"b2","series-title":"J Interferon Cytokine Res","first-page":"287","article-title":"Maternal-fetal transmission of Zika virus: routes and signals for infection","volume":"37","author":"Cao","year":"2017"},{"key":"b3","series-title":"Lancet","first-page":"2501","article-title":"Late sexual transmission of Zika virus related to persistence in the semen","volume":"387","author":"Turmel","year":"2016"},{"key":"b4","series-title":"Public Health","first-page":"66","article-title":"Zika, sexual transmission and prudent public health policy","volume":"148","author":"Folkers","year":"2017"},{"key":"b5","series-title":"Euro Surveill","first-page":"20761","article-title":"Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014","volume":"19","author":"Musso","year":"2014"},{"key":"b6","series-title":"New Engl J Med","first-page":"11","article-title":"Evidence for transmission of Zika virus by platelet transfusion","volume":"375","author":"Motta","year":"2016"},{"key":"b7","series-title":"Transfusion","first-page":"1684","article-title":"Probable transfusion-trasmitted Zika virus in Brazil","volume":"56","author":"Barjas-Castro","year":"2016"},{"key":"b8","series-title":"Arch Pathol Lab Med","first-page":"85","article-title":"Zika and the blood suply. A work in progress","volume":"141","author":"Katz","year":"2017"},{"key":"b9","author":"Municipal Health Department of Campinas","year":"2016"},{"key":"b10","series-title":"Transfusion","first-page":"215","article-title":"Probable and possible transfusion-transmitted dengue associated with NS1 antigen-negative but RNA confirmed-positive red blood cells","volume":"56","author":"Matos","year":"2016"},{"key":"b11","series-title":"Transfusion","first-page":"1657","article-title":"Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico","volume":"52","author":"Stramer","year":"2012"},{"key":"b12","series-title":"Transfusion","first-page":"961","article-title":"Real-time symptomatic case of transfusion-transmitted dengue","volume":"55","author":"Levi","year":"2015"},{"key":"b13","series-title":"Rev Bras Hematol Hemoter","first-page":"309","article-title":"Official comunique: chikungunya virus\u2013press release of the Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular regarding the safety of transfusions and transplants","volume":"36","author":"J\u00fanior","year":"2014"},{"key":"b14","author":"CDC-Centers for Disease Control and Prevention","year":"2016"},{"key":"b15","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"627","article-title":"Screening of blood donations for Zika virus infection\u2014Puerto Rico, April 3\u2013June 11, 2016","volume":"65","author":"Kuehnert","year":"2016"},{"key":"b16","series-title":"Blood Transfus","first-page":"95","article-title":"Zika v\u00edrus and the never-ending story of emerging pathogens and transfusion medicine","volume":"14","author":"Marano","year":"2016"},{"key":"b17","series-title":"Vox Sang","first-page":"312","article-title":"Collaborative study for the characterization of a chikungunya virus RNA reference reagent for use in nucleic acid testing","volume":"109","author":"A\u00f1ez","year":"2015"},{"key":"b18","series-title":"Transfusion","first-page":"748","article-title":"Harmonization of nucleic acid testing for Zika virus: development of the 1st World Health Organization International Standard","volume":"57","author":"Baylis","year":"2017"},{"key":"b19","series-title":"Transfusion","first-page":"734","article-title":"Relative analytical sensitivity of donor NAT screening and diagnostic real-time PCR assays for detection of Zika virus RNA","volume":"57","author":"Stone","year":"2017"},{"key":"b20","series-title":"Emerg Infect Dis","first-page":"1221","article-title":"High incidence of chikungunya virus and frequency of viremic blood donations during epidemic, Puerto Rico, USA, 2014","volume":"22","author":"Simmons","year":"2016"},{"key":"b21","series-title":"J Infect Dis","first-page":"49","article-title":"Duration of dengue viremia in blood donors and relationships between donor viremia, infection incidence and clinical case reports during a large epidemic","volume":"214","author":"Busch","year":"2016"},{"key":"b22","series-title":"Transfusion","first-page":"723","article-title":"Decision making in the face of uncertainty: the challenge of emerging infectious diseases","volume":"57","author":"Marks","year":"2017"},{"key":"b23","series-title":"Transfusion","first-page":"762","article-title":"First Zika positive donations in the continental United States","volume":"57","author":"Galel","year":"2017"},{"key":"b24","series-title":"Transfusion","first-page":"770","article-title":"First cases of Zika virus infected US blood donors outside states with areas of active transmission","volume":"57","author":"Williamson","year":"2017"},{"key":"b25","series-title":"J Infect Dis","first-page":"694","article-title":"Transfusion-transmitted dengue associated clinical symptoms during the 2012 epidemic in Brazil","volume":"213","author":"Sabino","year":"2016"},{"key":"b26","series-title":"Emerg Infect Dis","first-page":"336","article-title":"Accuracy of dengue reporting by National Surveillance System, Brazil","volume":"22","author":"Silva","year":"2016"},{"key":"b27","series-title":"Transfusion","first-page":"1907","article-title":"Zika virus: a new threat to the safety of the blood supply with worldwide impact and implications","volume":"56","author":"Lanteri","year":"2016"},{"key":"b28","author":"Brasil. 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