{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T18:10:03Z","timestamp":1722449403051},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,6]]},"abstract":"<jats:p>Although <jats:italic>Wuchereria bancrofti<\/jats:italic> (<jats:italic>Wb<\/jats:italic>), the causative agent of lymphatic filariasis, is endemic throughout Mali, the prevalence of <jats:italic>Wb<\/jats:italic> microfilaremia (Mf) can vary widely between villages despite similar prevalence of infection as assessed by circulating antigen. To examine this variation, cross-sectional data obtained during screening prior to an interventional study in two neighboring villages in Mali were analyzed. The overall prevalence of <jats:italic>Wb<\/jats:italic>, as assessed by <jats:italic>Wb<\/jats:italic> CAg (circulating antigen), was 50.3% among 373 participants, aged 14-65. <jats:italic>Wuchereria bancrofti<\/jats:italic> Mf-positive and negative individuals appeared randomly distributed across the two villages (Moran\u2019s I spatial statistic = -0.01, Z score =0.1, P&gt;0.05). Among the 187 subjects positive for <jats:italic>Wb<\/jats:italic> CAg, 117 (62.5%) had detectable <jats:italic>Mansonella perstans<\/jats:italic> microfilaremia (<jats:italic>Mp<\/jats:italic> Mf) and 64 (34.2%) had detectable <jats:italic>Wb<\/jats:italic> microfilaremia. The prevalence of <jats:italic>Mp<\/jats:italic> microfilaremia was 73.4% in the <jats:italic>Wb<\/jats:italic> Mf-positive group (as compared to 56.9% in the <jats:italic>Wb<\/jats:italic> Mf-negative group; p=0.01), and median <jats:italic>Wb<\/jats:italic> Mf load was increased in co-infected subjects (267Mf\/ml vs 100 Mf\/ml; p&lt;0.001). In multivariate analysis, village of residence, <jats:italic>Mp<\/jats:italic> Mf positivity and gender were significantly associated with <jats:italic>Wb<\/jats:italic> Mf positivity. After controlling for age, gender, and village of residence, the odds of being <jats:italic>Wb<\/jats:italic> Mf positive was 2.67 times higher in <jats:italic>Mp<\/jats:italic> positive individuals (95% confidence interval [1.42\u20135.01]). Given the geographical overlap between <jats:italic>Mp<\/jats:italic> and <jats:italic>Wb<\/jats:italic> in Africa, a better understanding of the distribution and prevalence of <jats:italic>Mp<\/jats:italic> could assist national lymphatic filariasis control programs in predicting areas of high <jats:italic>Wb<\/jats:italic> Mf prevalence that may require closer surveillance.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0902","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T07:00:24Z","timestamp":1525158024000},"page":"1782-1787","source":"Crossref","is-referenced-by-count":2,"title":["Factors Associated with Wuchereria bancrofti Microfilaremia in an Endemic Area of Mali"],"prefix":"10.4269","volume":"98","author":[{"given":"Housseini","family":"Dolo","sequence":"first","affiliation":[{"name":"Filariasis Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali;"},{"name":"Faculty of Medicine and Health Sciences, Global Health Institute, University of Antwerp, Antwerpen, Belgium;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaya Ibrahim","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Filariasis Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali;"},{"name":"Department of Parasitology, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Kelly-Hope","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siaka","family":"Konate","sequence":"additional","affiliation":[{"name":"Comit\u00e9 International de la Croix-Rouge (CICR), Kinshasa, 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Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Emmanuel","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Filariasis Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salif Seriba","family":"Doumbia","sequence":"additional","affiliation":[{"name":"Filariasis Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah Amadou","family":"Diallo","sequence":"additional","affiliation":[{"name":"Filariasis Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sekou Fantamady","family":"Traore","sequence":"additional","affiliation":[{"name":"Filariasis Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Colebunders","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Global Health Institute, University of Antwerp, Antwerpen, Belgium;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Nutman","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy D.","family":"Klion","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 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