{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:53:46Z","timestamp":1777478026320,"version":"3.51.4"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,2]]},"abstract":"<jats:p><jats:italic>Shigella<\/jats:italic> is a major cause of severe diarrhea in children less than the age of 5 years in sub-Saharan Africa. The aim of this study was to describe the (sub-)serotype distribution and antimicrobial susceptibility of <jats:italic>Shigella<\/jats:italic> serogroups from Centrafrican patients with diarrhea between 2002 and 2013. We collected 443 <jats:italic>Shigella<\/jats:italic> isolates in total. The most common serogroups were <jats:italic>Shigella flexneri<\/jats:italic> (<jats:italic>N<\/jats:italic> = 243, 54.9%), followed by <jats:italic>Shigella sonnei<\/jats:italic> (<jats:italic>N<\/jats:italic> = 90, 20.3%) and <jats:italic>Shigella dysenteriae<\/jats:italic> (<jats:italic>N<\/jats:italic> = 72, 16.3%). The high diversity of (sub-)serotypes of <jats:italic>S. flexneri<\/jats:italic> and <jats:italic>S. dysenteriae<\/jats:italic> may impede the development of an efficient vaccine. Rates of resistance were high for ampicillin, chloramphenicol, tetracycline, and cotrimoxazole but low for many other antimicrobials, confirming recommendations for the use of third-generation cephalosporins (only one organism resistant) and fluoroquinolones (no resistance). However, the detection of one extended-spectrum beta-lactamase\u2013producing <jats:italic>Shigella<\/jats:italic> organism highlights the need for continued monitoring of antimicrobial drug susceptibility.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0917","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:00:52Z","timestamp":1529996452000},"page":"283-286","source":"Crossref","is-referenced-by-count":14,"title":["Serotype Distribution and Antimicrobial Resistance of Shigella Species in Bangui, Central African Republic, from 2002 to 2013"],"prefix":"10.4269","volume":"99","author":[{"given":"Sebastien","family":"Breurec","sequence":"first","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Institut Pasteur de Bangui, Bangui, Central African Republic;"},{"name":"Facult\u00e9 de M\u00e9decine Hyacinthe Bastaraud, Universit\u00e9 des Antilles, Pointe-\u00e0-Pitre, France;"},{"name":"Laboratoire de Microbiologie Clinique et Environnementale, Centre Hospitalier Universitaire de Pointe-\u00e0-Pitre\/les Abymes, Pointe-\u00e0-Pitre, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clotaire","family":"Rafa\u00ef","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Institut Pasteur de Bangui, Bangui, Central African Republic;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuella","family":"Onambele","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Institut Pasteur de Bangui, Bangui, Central African Republic;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Frank","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Institut Pasteur de Bangui, Bangui, Central African Republic;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Farra","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Institut Pasteur de Bangui, Bangui, Central African Republic;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Legrand","sequence":"additional","affiliation":[{"name":"D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l\u2019Innovation, Centre Hospitalier Universitaire de Nantes, Nantes, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois-Xavier","family":"Weill","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Bact\u00e9ries Pathog\u00e8nes Ent\u00e9riques, Centre National de R\u00e9f\u00e9rence des Escherichia coli, Shigella et Salmonella, Institut Pasteur, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"430","article-title":"Global, regional, and national causes of child mortality in 2000\u201313, with projections to inform post-2015 priorities: an updated systematic 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