{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:07:22Z","timestamp":1790240842534,"version":"4.1.0"},"reference-count":11,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,5]]},"abstract":"<jats:p>We report here one case of Zika virus (ZIKV) infection associated with auto-immunity directed against the central nervous system in a Brazilian woman who developed acute transverse myelitis 9 days after recovery from an acute episode of fever with generalized erythema. Imaging of the spinal cord showed an elongated area on the T1\u2013T10 level with gadolinium uptake. The diagnostic of the ZIKV infection was confirmed by cerebrospinal fluid and serum analysis. This patient had serum positivity for autoantibodies against myelin oligodendrocyte glycoprotein (MOG), a specific antibody against the myelin sheath. We propose that a direct central nervous system infection by ZIKV could lead to a specific auto-immunity against MOG protein.<\/jats:p>","DOI":"10.4269\/ajtmh.17-0938","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T03:00:24Z","timestamp":1538449224000},"page":"1419-1421","source":"Crossref","is-referenced-by-count":35,"title":["Case Report: Acute Transverse Myelitis after Zika Virus Infection"],"prefix":"10.4269","volume":"99","author":[{"given":"Vanderson Carvalho","family":"Neri","sequence":"first","affiliation":[{"name":"Neurology Department, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Filomena","family":"Xavier","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Treatment Center, Hospital Federal da Lagoa, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Oliveira","family":"Barros","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleonice","family":"Melo Bento","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Marignier","sequence":"additional","affiliation":[{"name":"Service de Neurologie A and Eug\u00e8ne Devic EDMUS Foundation Against Multiple Sclerosis, Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques (OFSEP), H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France;"},{"name":"Universite\u00ec Lyon 1, Universite\u00ec de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Papais Alvarenga","sequence":"additional","affiliation":[{"name":"Neurology Department, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil;"},{"name":"Multiple Sclerosis Treatment Center, Hospital Federal da Lagoa, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"59","article-title":"Possible association between Zika virus infection and microcephaly-Brazil, 2015","volume":"65","author":"Schuler-Faccini","year":"2016"},{"key":"b2","series-title":"Med Mal Infect","first-page":"302","article-title":"Current Zika virus epidemiology and recent epidemics","volume":"44","author":"Ioos","year":"2014"},{"key":"b3","series-title":"PLoS Negl Trop Dis","first-page":"e0004636","article-title":"Zika v\u00edrus outbreak in Rio de Janeiro, Brazil: clinical characterization, epidemiological and virological aspects","volume":"10","author":"Brasil","year":"2016"},{"key":"b4","series-title":"N Engl J Med","first-page":"601","article-title":"Zikavirus in the Americas\u2014yet another arbovirus threat","volume":"374","author":"Fauci","year":"2016"},{"key":"b5","series-title":"Lancet","first-page":"1481","article-title":"Acute myelitis due to Zika virus infection","volume":"387","author":"M\u00e9charles","year":"2016"},{"key":"b6","series-title":"Brain","first-page":"2122","article-title":"Zika virus-associated neurological disorders: a review","volume":"139","author":"Araujo","year":"2016"},{"key":"b7","series-title":"Mult Scler","first-page":"312","article-title":"Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: clinical and prognostic implications","volume":"22","author":"Cobo-Calvo","year":"2016"},{"key":"b8","series-title":"Autoimmun 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Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/6\/article-p1419.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/6\/article-p1419.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/6\/article-p1419.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T09:43:43Z","timestamp":1722419023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/6\/article-p1419.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":11,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.17-0938","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,5]]}}}