{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T13:40:07Z","timestamp":1722433207357},"reference-count":9,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,3]]},"abstract":"<jats:p>Yemen is a country that has been treating severe cases of oncho-dermatitis since 1992 and is now moving to a program aimed at the elimination of the transmission of <jats:italic>Onchocerca volvulus<\/jats:italic>. It is important to ensure that the currently acceptable tools used in epidemiological assessment of onchocerciasis in Africa and Latin America also apply to Yemen. Five hundred and ten blood samples from three known <jats:italic>O. volvulus<\/jats:italic>\u2013endemic areas, locations that have never been under a mass treatment program, were tested for the presence of antibodies against a panel of <jats:italic>O. volvulus<\/jats:italic>\u2013specific antigens using enzyme-linked immunosorbent assay (Ov16) and luciferase immunoprecipitation system (Ov-FAR-1 and Ov-MSA-1) assays. Overall, 31.4% of the samples tested were positive, with positivity increasing with age. Positivity was seen in 76.5% of those presenting with clinical onchocerciasis but importantly also in more than 28.5% of those defined as free of oncho-dermatitis; these latter individuals are likely to be serving as a source for persistent reinfection. This study supports the use of the current <jats:italic>O. volvulus<\/jats:italic>\u2013specific serologic methodology in Yemen.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0051","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T07:00:43Z","timestamp":1533625243000},"page":"1049-1052","source":"Crossref","is-referenced-by-count":4,"title":["A Serological Survey of Human Onchocerciasis in Yemen"],"prefix":"10.4269","volume":"99","author":[{"given":"Charles D.","family":"Mackenzie","sequence":"first","affiliation":[{"name":"Liverpool School of Tropical Medicine, Pembroke Square, Liverpool, United Kigdom;"},{"name":"Neglected Tropical Diseases Support Center, Task Force for Global Health, Decatur, Illinois;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul-Samid","family":"Al-Kubati","sequence":"additional","affiliation":[{"name":"Yemeni Onchocerciasis Program, Tiaz, Yemen;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasin","family":"Al-Qubati","sequence":"additional","affiliation":[{"name":"Yemeni Onchocerciasis Program, Tiaz, Yemen;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Behan-Braman","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kubofcik","sequence":"additional","affiliation":[{"name":"Parasitology Laboratory, National Institutes of Health\/National Institute of Allergy and Infectious Diseases, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Perry Street, Kent, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Nutman","sequence":"additional","affiliation":[{"name":"Parasitology Laboratory, National Institutes of Health\/National Institute of Allergy and Infectious Diseases, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Trans R Soc Trop Med Hyg","first-page":"253","article-title":"Onchocerciasis in south Arabia","volume":"51","author":"Fawdry","year":"1957"},{"key":"b2","series-title":"Trans R Soc Trop Med Hyg","first-page":"343","article-title":"The first use of ivermectin for treatment of onchocerciasis in Yemen","volume":"88","author":"Al-Qubati","year":"1994"},{"key":"b3","series-title":"Int Health","first-page":"i89","article-title":"Onchocerciasis in Yemen: moving forward towards an elimination program","volume":"10","author":"Al-Kubati","year":"2018"},{"key":"b4","series-title":"Tropenmed Parasitol","first-page":"201","article-title":"Clinical, parasitological and serological studies on onchocerciasis in the Yemen Arab Republic","volume":"33","author":"B\u00fcttner","year":"1982"},{"key":"b5","series-title":"Trends Parasitol","first-page":"16","article-title":"Elimination of onchocerciasis from Africa: possible?","volume":"28","author":"Mackenzie","year":"2012"},{"year":"2016","author":"WHO","key":"b6"},{"key":"b7","series-title":"PLoS Negl Trop Dis","first-page":"e0004292","article-title":"A recombinant positive control for serology diagnostic tests supporting elimination of Onchocerca volvulus","volume":"10","author":"Golden","year":"2016"},{"key":"b8","series-title":"PLoS Negl Trop Dis","first-page":"e438","article-title":"A four-antigen mixture for rapid assessment of Onchocerca volvulus infection","volume":"3","author":"Burbelo","year":"2009"},{"year":"2012","author":"Mackenzie","key":"b9"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/4\/article-p1049.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/4\/article-p1049.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/4\/article-p1049.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T13:25:16Z","timestamp":1722432316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/4\/article-p1049.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,3]]},"references-count":9,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0051","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2018,10,3]]}}}