{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:49:21Z","timestamp":1776948561558,"version":"3.51.4"},"reference-count":27,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,6]]},"abstract":"<jats:p>Ventricular involvement in neurocysticercosis (NCC), a common serious manifestation of NCC, has distinct clinical presentations, complications, and treatments primarily because of partial or complete obstruction of the cerebrospinal fluid (CSF) flow by <jats:italic>Taenia solium<\/jats:italic> cysts. We review the clinical course, treatments, and long-term outcomes in 23 of 121 (19.0%) total NCC patients with ventricular cysts referred to the National Institutes of Health from 1985 to the October 2017. Patients had a median age of 31.8 (range: 22.4\u201352.6 years), were 60.9% male, diagnosed a median of 6.5 years (range: 0.17\u201316 years) after immigration, and were followed for a median of 3.6 years (range: 0.1\u201330.5 years). Other forms and manifestations of NCC were present in 73.9% (17\/23). The fourth ventricle was involved in a majority (15\/23, 65.2%) resulting in hydrocephalus (73.9%), ventriculitis, and periventricular edema (7\/23, 30.4%). Cystectomy was accomplished in 60.9%, usually by removal of a fourth ventricular cyst through a suboccipital craniotomy. Nonresectable cysts were treated medically. Ventriculoperitoneal shunts were inserted in 43.5% (10\/23) and failed in four, three from infection. Other complications included surgically induced injuries (4\/23, 17.4%) and entrapment of a lateral ventricle (2\/23, 8.7%). Despite a common severe early course, 90.9% (20\/22) stabilized without recurrence, 15% (3\/20) complained of mild-to-moderate neurological complaints, and 15% (3\/20) were significantly disabled. Four patients who underwent removal of ventricular cysts without significant other NCC and who received with no cysticidal treatment became CSF cestode antigen negative without recurrence indicating that after successful extraction of cysts, additional cysticidal treatment may not be needed.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0085","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T07:00:42Z","timestamp":1524553242000},"page":"1755-1762","source":"Crossref","is-referenced-by-count":44,"title":["Intraventricular Neurocysticercosis: Experience and Long-Term Outcome from a Tertiary Referral Center in the United States"],"prefix":"10.4269","volume":"98","author":[{"given":"Theodore E.","family":"Nash","sequence":"first","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JeanAnne M.","family":"Ware","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddhartha","family":"Mahanty","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet Neurol","first-page":"1202","article-title":"Clinical symptoms, diagnosis, and treatment of neurocysticercosis","volume":"13","author":"Garcia","year":"2014"},{"key":"b2","series-title":"J Neurosurg","first-page":"400","article-title":"Surgical considerations in treatment of intraventricular cysticercosis. An analysis of 45 cases","volume":"60","author":"Apuzzo","year":"1984"},{"key":"b3","series-title":"Neurosurg Focus","first-page":"e5","article-title":"Intraventricular neurocysticercosis: 18 consecutive patients and review of the literature","volume":"12","author":"Cuetter","year":"2002"},{"key":"b4","series-title":"Neurosurgery","first-page":"148","article-title":"Intraventricular cysticercosis","volume":"12","author":"Madrazo","year":"1983"},{"key":"b5","series-title":"Br J Neurosurg","first-page":"305","article-title":"Intraventricular neurocysticercosis: a review of current status and management issues","volume":"26","author":"Sinha","year":"2012"},{"key":"b6","series-title":"Neurosurg Focus","first-page":"e6","article-title":"Imaging features and surgery-related outcomes in intraventricular neurocysticercosis","volume":"12","author":"Citow","year":"2002"},{"key":"b7","series-title":"Arq Neuropsiquiatr","first-page":"166","article-title":"Cysticercosis of the central nervous system. I. Surgical treatment of cerebral cysticercosis: a 23 years experience in the Hospital das Clinicas of Ribeirao Preto Medical School","volume":"52","author":"Colli","year":"1994"},{"key":"b8","series-title":"Surg Neurol","first-page":"305","article-title":"Isolated fourth ventricle in neurocysticercosis: pathophysiology, diagnosis, and treatment","volume":"39","author":"Colli","year":"1993"},{"key":"b9","series-title":"Surg Neurol","first-page":"247","article-title":"Double compartment hydrocephalus in a patient with cysticercosis meningitis","volume":"4","author":"DeFeo","year":"1975"},{"key":"b10","series-title":"J Neurosurg","first-page":"340","article-title":"Endoscopic removal of cysticercal cysts within the fourth ventricle. Technical note","volume":"91","author":"Bergsneider","year":"1999"},{"key":"b11","series-title":"Neurosurgery","first-page":"1040","article-title":"An endoscopic approach to cysticercosis cysts of the posterior third ventricle","volume":"36","author":"Neal","year":"1995"},{"key":"b12","series-title":"Neurology","first-page":"177","article-title":"Proposed diagnostic criteria for neurocysticercosis","volume":"57","author":"Del Brutto","year":"2001"},{"key":"b13","series-title":"Vet Parasitol","first-page":"43","article-title":"Sero-epidemiological study of Taenia saginata cysticercosis in Belgian cattle","volume":"88","author":"Dorny","year":"2000"},{"key":"b14","series-title":"J Infect Dis","first-page":"1141","article-title":"Natural history of patients with perilesional edema around Taenia solium calcified granulomas","volume":"215","author":"Nash","year":"2017"},{"key":"b15","series-title":"J Neurol Sci","first-page":"25","article-title":"Medical and surgical treatment in neurocysticercosis a magnetic resonance study of 161 cases","volume":"130","author":"Martinez","year":"1995"},{"key":"b16","series-title":"Medicine (Baltimore)","first-page":"81","article-title":"Neurocysticercosis in Houston, Texas: an update","volume":"90","author":"Serpa","year":"2011"},{"key":"b17","series-title":"PLoS Negl Trop Dis","first-page":"e0005646","article-title":"Extraparenchymal neurocysticercosis: demographic, clinicoradiological, and inflammatory features","volume":"11","author":"Marcin","year":"2017"},{"key":"b18","series-title":"Arch Neurol","first-page":"534","article-title":"Cysticercosis cerebri. Review of 127 cases","volume":"39","author":"McCormick","year":"1982"},{"key":"b19","author":"Dixon","year":"1961"},{"key":"b20","series-title":"J Neurosurg","first-page":"382","article-title":"Neurosurgical considerations of cysticercosis of the central nervous system","volume":"55","author":"Stern","year":"1981"},{"key":"b21","series-title":"Clin Neurol Neurosurg","first-page":"11","article-title":"Endoscopic management of hydrocephalus due to neurocysticercosis","volume":"112","author":"Torres-Corzo","year":"2010"},{"key":"b22","series-title":"J Clin Neurosci","first-page":"1096","article-title":"Endoscopic management of intraventricular neurocysticercosis","volume":"15","author":"Goel","year":"2008"},{"key":"b23","series-title":"Childs Nerv Syst","first-page":"1467","article-title":"Intraventricular and subarachnoid basal cisterns neurocysticercosis: a comparative study between traditional treatment versus neuroendoscopic surgery","volume":"25","author":"Proano","year":"2009"},{"key":"b24","series-title":"Int J Surg","first-page":"100","article-title":"Surgical management of neurocysticercosis","volume":"8","author":"Rajshekhar","year":"2010"},{"key":"b25","series-title":"World Neurosurg","first-page":"558","article-title":"What is the utility of postoperative antihelminthic therapy after resection for intraventricular neurocysticercosis?","volume":"79","author":"Khade","year":"2013"},{"key":"b26","series-title":"J Neurosurg","first-page":"29","article-title":"Albendazole and praziquantel treatment in neurocysticercosis of the fourth ventricle","volume":"87","author":"Proano","year":"1997"},{"key":"b27","series-title":"Clin Infect Dis","first-page":"549","article-title":"Methotrexate as a corticosteroid-sparing agent in complicated neurocysticercosis","volume":"44","author":"Mitre","year":"2007"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/98\/6\/article-p1755.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/98\/6\/article-p1755.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/98\/6\/article-p1755.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T17:30:10Z","timestamp":1722447010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/98\/6\/article-p1755.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,6]]},"references-count":27,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0085","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,6]]}}}