{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:33:55Z","timestamp":1790660035029,"version":"4.1.0"},"reference-count":43,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,2]]},"abstract":"<jats:p>\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    (L.) (Diptera: Culicidae) have a global distribution and are the primary vector of a number of mosquito-borne viruses responsible for epidemics throughout the Americas. As in much of South America, the threat from pathogens including dengue virus (DENV; Flaviviridae,\n                    <jats:italic>Flavivirus<\/jats:italic>\n                    ) and chikungunya virus (CHIKV; Togaviridae,\n                    <jats:italic>Alphavirus<\/jats:italic>\n                    ) has increased in Argentina in recent years. The complexity of transmission cycles makes predicting the occurrence and intensity of arbovirus outbreaks difficult. To gain a better understanding of the risk of DENV and CHIKV in Argentina and the factors influencing this risk, we evaluated the role of population and temperature in the vector competence and vectorial capacity (VC) of\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    from geographically and ecologically distinct locations. Our results demonstrate that intrinsic and extrinsic factors including mosquito population, viral species, and temperature significantly influence both vector competence and overall VC of\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    in Argentina, yet also that the magnitude of these influences is highly variable. Specifically, results suggest that CHIKV competence is more dependent on mosquito genetics than is DENV competence, whereas temperature has a greater effect on DENV transmission. In addition, although there is an overall positive correlation between temperature and competence for both viruses, there are exceptions to this for individual virus\u2013population combinations. Together, these data establish large variability in VC for these pathogens among distinct\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    populations in Argentina and demonstrate that accurate assessment of arbovirus risk will require nuanced models that fully consider the complexity of interactions between virus, temperature, mosquito genetics, and hosts.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.18-0097","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T03:00:49Z","timestamp":1528167649000},"page":"417-424","source":"Crossref","is-referenced-by-count":44,"title":["Differential Effects of Temperature and Mosquito Genetics Determine Transmissibility of Arboviruses by Aedes aegypti in Argentina"],"prefix":"10.4269","volume":"99","author":[{"given":"Alexander T.","family":"Ciota","sequence":"first","affiliation":[{"name":"The Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, New York;"},{"name":"Department of Biomedical Sciences, Albany School of Public Health, State University of New York, Albany, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A.","family":"Chin","sequence":"additional","affiliation":[{"name":"The Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan J.","family":"Ehrbar","sequence":"additional","affiliation":[{"name":"The Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Victoria","family":"Micieli","sequence":"additional","affiliation":[{"name":"Centro de Estudios Parasitol\u00f3gicos y de Vectores, CONICET, La Plata, Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina M.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Center for Vector Biology, Rutgers University, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Kramer","sequence":"additional","affiliation":[{"name":"The Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, New York;"},{"name":"Department of Biomedical Sciences, Albany School of Public Health, State University of New York, Albany, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Evolution","first-page":"514","article-title":"Human impacts have shaped historical and recent evolution in Aedes aegypti, the dengue and yellow fever mosquito","volume":"68","author":"Brown","year":"2014"},{"key":"b2","series-title":"J Med Entomol","first-page":"509","article-title":"Emergent and reemergent arboviruses in South America and the Caribbean: why so many and why now?","volume":"54","author":"Marcondes","year":"2017"},{"key":"b3","series-title":"Math Biosci","first-page":"32","article-title":"Stochastic eco-epidemiological model of dengue disease transmission by Aedes aegypti mosquito","volume":"223","author":"Otero","year":"2010"},{"key":"b4","author":"Pan American Health Organization","year":"2017"},{"key":"b5","series-title":"Curr Opin Virol","first-page":"81","article-title":"Complexity of virus-vector interactions","volume":"21","author":"Kramer","year":"2016"},{"key":"b6","series-title":"Virol J","first-page":"114","article-title":"Vector competence of Aedes aegypti in transmitting chikungunya virus: effects and implications of extrinsic incubation temperature on dissemination and infection rates","volume":"13","author":"Mbaika","year":"2016"},{"key":"b7","series-title":"Vector Borne Zoonotic Dis","first-page":"629","article-title":"Impact of extrinsic incubation temperature and virus exposure on vector competence of Culex pipiens quinquefasciatus Say (Diptera: Culicidae) for West Nile virus","volume":"7","author":"Richards","year":"2007"},{"key":"b8","series-title":"Am J Trop Med Hyg","first-page":"1130","article-title":"Effect of temperature of extrinsic incubation on the vector competence of Culex tarsalis for western equine enephalomyelitis virus","volume":"32","author":"Kramer","year":"1983"},{"key":"b9","series-title":"Am J Trop Med Hyg","first-page":"689","article-title":"Reduction of Aedes aegypti vector competence for dengue virus under large temperature fluctuations","volume":"88","author":"Carrington","year":"2013"},{"key":"b10","series-title":"Proc Natl Acad Sci U S A","first-page":"7460","article-title":"Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti","volume":"108","author":"Lambrechts","year":"2011"},{"key":"b11","series-title":"J Med Entomol","first-page":"681","article-title":"The impact of cycling temperature on the transmission of West Nile virus","volume":"53","author":"Danforth","year":"2016"},{"key":"b12","series-title":"PLoS Pathog","first-page":"e1000092","article-title":"Temperature, viral genetics, and the transmission of West Nile virus by Culex pipiens mosquitoes","volume":"4","author":"Kilpatrick","year":"2008"},{"key":"b13","series-title":"J Med Entomol","first-page":"55","article-title":"The effect of temperature on life history traits of Culex mosquitoes","volume":"51","author":"Ciota","year":"2014"},{"key":"b14","series-title":"Environ Health Insights","first-page":"5","article-title":"Potential for extrinsic incubation temperature to alter interplay between transmission potential and mortality of dengue-infected Aedes aegypti","volume":"10","author":"Christofferson","year":"2016"},{"key":"b15","series-title":"Am J Trop Med Hyg","first-page":"607","article-title":"Spatial and temporal variation in vector competence of Culex pipiens and Cx. restuans mosquitoes for West Nile virus","volume":"83","author":"Kilpatrick","year":"2010"},{"key":"b16","series-title":"PLoS One","first-page":"e92971","article-title":"Differential susceptibility of two field Aedes aegypti populations to a low infectious dose of dengue virus","volume":"9","author":"Pongsiri","year":"2014"},{"key":"b17","series-title":"Funct Integr Genomics","first-page":"581","article-title":"Influence of mosquito genotype on transcriptional response to dengue virus infection","volume":"14","author":"Behura","year":"2014"},{"key":"b18","series-title":"Proc Biol Sci","first-page":"20122437","article-title":"Specificity of resistance to dengue virus isolates is associated with genotypes of the mosquito antiviral gene Dicer-2","volume":"280","author":"Lambrechts","year":"2013"},{"key":"b19","series-title":"PLoS Genet","first-page":"e1003621","article-title":"Genetic mapping of specific interactions between Aedes aegypti mosquitoes and dengue viruses","volume":"9","author":"Fansiri","year":"2013"},{"key":"b20","series-title":"Proc Biol Sci","first-page":"20141078","article-title":"Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential","volume":"281","author":"Zouache","year":"2014"},{"key":"b21","series-title":"Proc Biol Sci","first-page":"20171506","article-title":"Infection rate of Aedes aegypti mosquitoes with dengue virus depends on the interaction between temperature and mosquito genotype","volume":"284","author":"Gloria-Soria","year":"2017"},{"key":"b22","series-title":"Bio Protoc","first-page":"e2542","article-title":"Rearing of Culex spp. and Aedes spp. mosquitoes","volume":"7","author":"Kauffman","year":"2017"},{"key":"b23","series-title":"Sci Transl Med","first-page":"114ra128","article-title":"Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity","volume":"3","author":"OhAinle","year":"2011"},{"key":"b24","series-title":"Emerg Infect Dis","first-page":"764","article-title":"Chikungunya virus in US travelers returning from India, 2006","volume":"13","author":"Lanciotti","year":"2007"},{"key":"b25","series-title":"J Virol Methods","first-page":"183","article-title":"Quantitation of flaviviruses by fluorescent focus assay","volume":"134","author":"Payne","year":"2006"},{"key":"b26","series-title":"J Med Ent","article-title":"Factors related to Aedes aegypti (Diptera: Culicidae) populations and temperature determine differences on life-history traits with regional implications in disease transmission","author":"Muttis","year":"2018"},{"key":"b27","series-title":"G3 (Bethesda)","first-page":"711","article-title":"A multipurpose, high-throughput single-nucleotide polymorphism chip for the dengue and yellow fever mosquito, Aedes aegypti","volume":"5","author":"Evans","year":"2015"},{"key":"b28","series-title":"Genetics","first-page":"573","article-title":"fastSTRUCTURE: variational inference of population structure in large SNP data sets","volume":"197","author":"Raj","year":"2014"},{"key":"b29","series-title":"Genetics","first-page":"945","article-title":"Inference of population structure using multilocus genotype data","volume":"155","author":"Pritchard","year":"2000"},{"key":"b30","series-title":"Conserv Genet Resour","first-page":"359","article-title":"STRUCTURE HARVESTER: a website and program for visualizing STRUCTURE output and implementing the Evanno method","volume":"4","author":"Earl","year":"2012"},{"key":"b31","series-title":"Mol Ecol","first-page":"2611","article-title":"Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study","volume":"14","author":"Evanno","year":"2005"},{"key":"b32","year":"2017"},{"key":"b33","series-title":"Proc Natl Acad Sci U S A","first-page":"9072","article-title":"Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes","volume":"110","author":"Nguyet","year":"2013"},{"key":"b34","series-title":"Am J Trop Med Hyg","first-page":"1045","article-title":"Variation in suseptibility to oral infection with dengue viruses among geographic strains of Aedes aegypti","volume":"28","author":"Gubler","year":"1979"},{"key":"b35","series-title":"Am J Trop Med Hyg","first-page":"539","article-title":"Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti","volume":"68","author":"Armstrong","year":"2003"},{"key":"b36","series-title":"Mol Biol Evol","first-page":"1533","article-title":"Phylogeography and population dynamics of dengue viruses in the Americas","volume":"29","author":"Allicock","year":"2012"},{"key":"b37","series-title":"Virus Evol","first-page":"vex010","article-title":"Understanding the evolution and spread of chikungunya virus in the Americas using complete genome sequences","volume":"3","author":"Sahadeo","year":"2017"},{"key":"b38","series-title":"PLoS Pathog","first-page":"e1002412","article-title":"Sequential adaptive mutations enhance efficient vector switching by chikungunya virus and its epidemic emergence","volume":"7","author":"Tsetsarkin","year":"2011"},{"key":"b39","series-title":"Curr Opin Virol","first-page":"310","article-title":"Chikungunya virus: evolution and genetic determinants of emergence","volume":"1","author":"Tsetsarkin","year":"2011"},{"key":"b40","series-title":"BMC Evol Biol","first-page":"71","article-title":"The evolution of virulence of West Nile virus in a mosquito vector: implications for arbovirus adaptation and evolution","volume":"13","author":"Ciota","year":"2013"},{"key":"b41","series-title":"The Biology of Disease Vectors","first-page":"187","article-title":"Chapter 15. Population biology as a tool to study vector-borne diseases","author":"Black","year":"1996"},{"key":"b42","series-title":"BMC Infect Dis","first-page":"49","article-title":"Assessing chikungunya risk in a metropolitan area of Argentina through satellite images and mathematical models","volume":"16","author":"Ruiz-Moreno","year":"2016"},{"key":"b43","series-title":"Emerg Infect Dis","first-page":"1684","article-title":"Dengue virus 1 outbreak in Buenos Aires, Argentina, 2016","volume":"23","author":"Tittarelli","year":"2017"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/2\/article-p417.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/2\/article-p417.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/2\/article-p417.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T15:34:07Z","timestamp":1722440047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/2\/article-p417.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,2]]},"references-count":43,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0097","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,2]]}}}