{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:27:57Z","timestamp":1791959277245,"version":"4.3.4"},"reference-count":42,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,5]]},"abstract":"<jats:p>We measured the prevalence of malaria in pregnancy and estimated its impact on birth weight and length and maternal hemoglobin in 1,180 women from Juru\u00e1 Valley, the main malaria hotspot in Brazil. Antenatal malaria episodes, 74.6% of them due to <jats:italic>Plasmodium vivax<\/jats:italic>, were microscopically diagnosed in 8.0% of the women and were associated with an average reduction in birth weight <jats:italic>z<\/jats:italic>-scores of 0.35 (95% confidence interval [CI] = 0.14\u20130.57) and in birth length <jats:italic>z<\/jats:italic>-scores of 0.31 (95% CI = 0.08\u20130.54), compared with malaria-free pregnancies. Affected mothers had a mean decrease in hemoglobin concentration at delivery of 0.33 g\/100 mL (95% CI = 0.05\u20130.62 g\/100 mL); 51.6% were anemic. The timing and frequency of antenatal infections influenced pregnancy outcomes and first- or second-trimester infections were not associated with decreased birth weight and length and maternal hemoglobin at delivery. Although repeated antenatal vivax infections were associated with poorer birth outcomes, even a single vivax malaria episode was associated with a significant reduction in birth weight and length and maternal hemoglobin. Overall, 7.5% women had the parasite\u2019s DNA found in peripheral blood at delivery. Most (83.1%) of these 89 perinatal infections were due to <jats:italic>P. vivax<\/jats:italic> and only 7.9% of them progressed to symptomatic disease after delivery. <jats:italic>Plasmodium vivax<\/jats:italic> and <jats:italic>Plasmodium falciparum<\/jats:italic> DNA was found in 0.6% and 0.3% of 637 cord blood samples examined, respectively, but only one newborn developed clinical neonatal malaria. Our results further challenge the notion that vivax malaria is relatively benign during pregnancy and call for better strategies for its prevention.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0135","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T07:00:58Z","timestamp":1525849258000},"page":"73-83","source":"Crossref","is-referenced-by-count":42,"title":["The Hidden Burden of Plasmodium vivax Malaria in Pregnancy in the Amazon: An Observational Study in Northwestern Brazil"],"prefix":"10.4269","volume":"99","author":[{"given":"Anaclara","family":"Pincelli","sequence":"first","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo A. R.","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara H.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"},{"name":"Department of Preventive Medicine, Escola Paulista de Medicina, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo M.","family":"Corder","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00edra B.","family":"Malta","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Sampaio-Silva","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo M.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marly A.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia C.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo U.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"},{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"},{"name":"Department of Preventive Medicine, Escola Paulista de Medicina, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"},{"name":"Multidisciplinary Center, Federal University of Acre, Cruzeiro do Sul, Brazil;"},{"name":"Department of Global Health and Population, Harvard T. H. 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